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Gene |

Product(s) |

Expression|

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Standard Name	frvR
Gene Synonym(s)	ECK3890, b3897, JW3868, yiiH^[1], yiiH
Product Desc.	FrvR predicted transcriptional regulator^[2]^[3] Putative frv operon regulator^[4]
Product Synonyms(s)	predicted regulator^[1], B3897^[2]^[1], YiiH^[2]^[1], FrvR^[2]^[1] , ECK3890, JW3868, yiiH, b3897
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): frvR^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	frvR
Mnemonic	Fructose
Synonyms	ECK3890, b3897, JW3868, yiiH^[1], yiiH
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	88.07 minutes	MG1655: 4087878..4086130 <gbrowseImage> name=NC_000913:4086130..4087878 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4068002..4066254 <gbrowseImage> name=NC_012967:4066254..4068002 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3975799..3977547 <gbrowseImage> name=NC_012759:3975799..3977547 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3546826..3548574 <gbrowseImage> name=NC_007779:3546826..3548574 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4187575..4185827 <gbrowseImage> name=NC_010473:4185827..4187575 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔfrvR (Keio:JW3868)	deletion	deletion	PMID:16738554	Shigen CGSC10793^[5]
ΔfrvR760::kan			PMID:16738554	CGSC:101030
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3868	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCTAAACGAACGCCAGTTAAA Primer 2:CCgCCCTTGTGAAGTAACTCCAT
7G8	Kohara Phage	Genobase	PMID:3038334
6H5	Kohara Phage	Genobase	PMID:3038334
zih-35::Tn10	Linked marker	CAG18495 = CGSC7467^[5]	est. P1 cotransduction: 45% ^[6]
pflD501::Tn10	Linked marker	CAG18477 = CGSC7470^[5]	est. P1 cotransduction: 6% ^[6] Synonyms:zij-501::Tn10 nnnCAG18477 also carries metF79(Am) (CGSC).
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11861	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11861	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001792	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948389	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1807	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012720	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	FrvR
Synonyms	predicted regulator^[1], B3897^[2]^[1], YiiH^[2]^[1], FrvR^[2]^[1] , ECK3890, JW3868, yiiH, b3897
Product description	FrvR predicted transcriptional regulator^[2]^[3] Putative frv operon regulator^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003677	DNA binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0238	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005215	transporter activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016152	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005351	sugar:hydrogen symporter activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002178	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006350	transcription	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0804	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006350	transcription	PMID:8019415	ISS: Inferred from Sequence or Structural Similarity	Swiss-Prot:P0A2P8	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006810	transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002178	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006810	transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016152	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002178	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016301	kinase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016564	transcription repressor activity	PMID:8019415	ISS: Inferred from Sequence or Structural Similarity	Swiss-Prot:P0A2P8	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016740	transferase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	groL		PMID:16606699	Experiment(s):EBI-1146937
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLNERQLKIV DLLEQQPRTP GELAQQTGVS GRTILRDIDY LNFTLNGKAR IFASGSAGYQ LEIFERRSFF QLLQKHDNDD RLLALLLLNT FTPRAQLASA LNLPETWVAE RLPRLKQRYE RTCCLASRPG LGHFIDETEE KRVILLANLL RKDPFLIPLA GITRDNLQHL STACDNQHRW PLMQGDYLSS LILAIYALRN QLTDEWPQYP GDEIKQIVEH SGLFLGDNAV RTLTGLIEKQ HQQAQVISAD NVQGLLQRVP GIASLNIIDA QLVENITGHL LRCLAAPVWI AEHRQSSMNN LKAAWPAAFD MSLHFITLLR EQLDIPLFDS DLIGLYFACA LERHQNERQP IILLSDQNAI ATINQLAIER DVLNCRVIIA RSLSELVAIR EEIEPLLIIN NSHYLLDDAV NNYITVKNII TAAGIEQIKH FLATAFIRQQ PERFFSAPGS FHYSNVRGES WQHITRQICA QLVAQHHITA DEAQRIIARE GEGENLIVNR LAIPHCWSEQ ERRFRGFFIT LAQPVEVNNE VINHVLIACA AADARHELKI FSYLASILCQ HPAEIIAGLT GYEAFMELLH KG
Length	582
Mol. Wt	66.001 kDa
pI	6.4 (calculated)
Extinction coefficient	56,380 - 57,630 (calc based on 12 Y, 7 W, and 10 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	447..581	PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	PMID:19920124
Domain	5..60	PF08279 HTH domain	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=frvR taxon=12017 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131737	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948389	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012720	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P32152	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11861	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11861	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948389	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001792	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1807	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
frvR
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4087858..4087898 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3897 (EcoliWiki Page)	NCBI GEO profiles for frvR
microarray	GenExpDB:b3897 (EcoliWiki Page)	Summary of data for frvR from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to frvR Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11861	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1807	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3897
EcoGene	EcoGene:EG11861	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001792	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012720	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	FRVR	From SHIGELLACYC
E. coli O157	FRVR	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:55804
Pfam (EcoliWiki Page)	PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2
Pfam (EcoliWiki Page)	PF08279 HTH domain
EcoCyc	EcoCyc:EG11861	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11861	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001792	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1807	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012720	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

frvR:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to frvR Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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