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Expression|

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Standard Name	etp
Gene Synonym(s)	ECK0973, b0982, JW5132, yccY^[1], yccY
Product Desc.	phosphotyrosine-protein phosphatase^[2]^[3] Cryptic phosphotyrosine-protein phosphatase; responsible for dephosphorylating the Etk-P autokinase; required for formation of the O-antigen capsule; silenced by IS1D insertion in promoter region^[4]
Product Synonyms(s)	phosphotyrosine-protein phosphatase^[1], B0982^[2]^[1], Etp^[2]^[1], YccY^[2]^[1] , ECK0973, JW5132, yccY, b0982
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yccC^[2]
Regulation/Activity
Quick Links
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Notes

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Function characterized in enteropathogenic E. coli (EPEC). Part of the ymcDCBA-yccZ-etp-etk operon. etp and wzb are paralogs. Also capable of dephosphorylating the Wzc-P autokinase in vitro.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	etp
Mnemonic	E. coli phosphoTyrosine-protein Phosphatase
Synonyms	ECK0973, b0982, JW5132, yccY^[1], yccY
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	22.49 minutes	MG1655: 1043899..1043453 <gbrowseImage> name=NC_000913:1043453..1043899 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1061321..1061767 <gbrowseImage> name=NC_012967:1061321..1061767 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 946421..946867 <gbrowseImage> name=NC_012759:946421..946867 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1045098..1044652 <gbrowseImage> name=NC_007779:1044652..1045098 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1097827..1097381 <gbrowseImage> name=NC_010473:1097381..1097827 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability
Δetp (Keio:JW5132)	deletion	deletion			PMID:16738554	Shigen
ΔyccY::kan	deletion		Biolog:respiration	unable to respire Acetate	PMID:16095938
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW5132	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGCCCAACTAAAATTTAACTC Primer 2:CCaCGGCTGAGGCGCTTCGCCCA
4H11	Kohara Phage	Genobase	PMID:3038334
zcb-3059::Tn10	Linked marker	CAG12094 = CGSC7358^[5]	est. P1 cotransduction: 17% ^[6]
zcc-282::Tn10	Linked marker	CAG18466 = CGSC7359^[5]	est. P1 cotransduction: 50% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6503	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13727	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003103	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945236	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3491	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003312	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	Etp
Synonyms	phosphotyrosine-protein phosphatase^[1], B0982^[2]^[1], Etp^[2]^[1], YccY^[2]^[1] , ECK0973, JW5132, yccY, b0982
Product description	phosphotyrosine-protein phosphatase^[2]^[3] Cryptic phosphotyrosine-protein phosphatase; responsible for dephosphorylating the Etk-P autokinase; required for formation of the O-antigen capsule; silenced by IS1D insertion in promoter region^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0004721	phosphoprotein phosphatase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0904	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004725	protein tyrosine phosphatase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000106	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004725	protein tyrosine phosphatase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017867	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004725	protein tyrosine phosphatase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:3.1.3.48	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006470	protein amino acid dephosphorylation	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000106	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006470	protein amino acid dephosphorylation	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017867	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MDSNMAQLKF NSILVVCTGN ICRSPIGERL LRKRLPGVKV KSAGVHGLVK HPADATAADV AANHGVSLEG HAGRKLTAEM ARNYDLILAM ESEHIAQVTA IAPEVRGKTM LFGQWLEQKE IPDPYRKSQD AFEHVYGMLE RASQEWAKRL SR
Length	152
Mol. Wt	16.833 kDa
pI	9.4 (calculated)
Extinction coefficient	15,470 - 15,720 (calc based on 3 Y, 2 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	7..145	PF01451 Low molecular weight phosphotyrosine protein phosphatase		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=etp taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111198	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945236	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003312	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0ACZ2	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6503	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13727	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945236	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003103	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3491	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	44	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	33	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	8^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yccC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1043879..1043919 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0982 (EcoliWiki Page)	NCBI GEO profiles for etp
microarray	GenExpDB:b0982 (EcoliWiki Page)	Summary of data for etp from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to etp Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6503	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3491	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0982
EcoGene	EcoGene:EG13727	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003103	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003312	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000012280 (score: 1.000; bootstrap: 100%) ENSANGP00000011124 (score: 0.224)	From Inparanoid:20070104
Apis mellifera	ENSAPMP00000017940 (score: 1.000; bootstrap: 100%) ENSAPMP00000031086 (score: 0.057)	From Inparanoid:20070104
Arabidopsis thaliana	AT3G44620 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000005122 (score: 0.977) ENSBTAP00000027314 (score: 1.000; bootstrap: 100%) ENSBTAP00000010570 (score: 0.779)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00034592 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-050327-12 (score: 1.000; bootstrap: 100%) ZDB-CDNA-050327-12 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Drosophila melanogaster	FBgn0040076 (score: 1.000; bootstrap: 100%) FBgn0040077 (score: 1.000; bootstrap: 100%) FBgn0051469 (score: 0.249) FBgn0038655 (score: 0.108)	From Inparanoid:20070104
Drosophila pseudoobscura	GA16170-PA (score: 1.000; bootstrap: 100%) GA16272-PA (score: 1.000; bootstrap: 100%) GA12886-PA (score: 0.205)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000026345 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000272065 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Mus musculus	MGI:87881 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q6ZJ11 (score: 1.000; bootstrap: 100%) Q84PD6 (score: 0.994)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000019951 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000007287 (score: 1.000; bootstrap: 100%) ENSRNOP00000050003 (score: 0.128)	From Inparanoid:20070104
Saccharomyces cerevisiae	YPR073C (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC10712c (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000030833 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	YCCY	From SHIGELLACYC
E. coli O157	YCCY	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01451 Low molecular weight phosphotyrosine protein phosphatase
Superfamily (EcoliWiki Page)	SUPERFAMILY:52788
EcoCyc	EcoCyc:G6503	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13727	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003103	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3491	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003312	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

etp:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to etp Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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