clpP:Gene Product(s)
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| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
ClpP |
|---|---|
| Synonyms |
proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases[1], B0437[2][1], LopP[2][1], heat shock protein F21.5[2][1] , ECK0431, JW0427, lopP, wseA, b0437 |
| Product description |
Component of ClpP serine protease[3]; ClpAXP[3]; ClpXP[3]; ClpAP[3] Proteolytic subunit of ClpXP and ClpAP ATP-dependent proteases; protease Ti[4] |
| EC number (for enzymes) | |
| edit table |
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Notes
Function
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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000166 |
nucleotide binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004252 |
serine-type endopeptidase activity |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004252 |
serine-type endopeptidase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004252 |
serine-type endopeptidase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0006508 |
proteolysis |
GOA:hamap |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006508 |
proteolysis |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006508 |
proteolysis |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006515 |
misfolded or incompletely synthesized protein catabolic process |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0006950 |
response to stress |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0008233 |
peptidase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0009408 |
response to heat |
IEP: Inferred from Expression Pattern |
P |
complete | ||||
| GO:0008236 |
serine-type peptidase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc (v14.0) |
complete | |||
| GO:0016787 |
hydrolase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of ClpP serine protease |
could be indirect |
||
|
Protein |
groL |
Experiment(s):EBI-884584, EBI-891481 | ||
|
Protein |
narG |
Experiment(s):EBI-884584 | ||
|
Protein |
narZ |
Experiment(s):EBI-884584 | ||
|
Protein |
parE |
Experiment(s):EBI-884584 | ||
|
Protein |
recA |
Experiment(s):EBI-884584 | ||
|
Protein |
hldD |
Experiment(s):EBI-884584, EBI-891481 | ||
|
Protein |
rho |
Experiment(s):EBI-884584 | ||
|
Protein |
rplJ |
Experiment(s):EBI-884584 | ||
|
Protein |
rplM |
Experiment(s):EBI-884584 | ||
|
Protein |
rplS |
Experiment(s):EBI-884584 | ||
|
Protein |
rpoC |
Experiment(s):EBI-884584 | ||
|
Protein |
rpsG |
Experiment(s):EBI-884584, EBI-891481 | ||
|
Protein |
rpsJ |
Experiment(s):EBI-884584 | ||
|
Protein |
secA |
Experiment(s):EBI-884584 | ||
|
Protein |
tufA |
Experiment(s):EBI-884584, EBI-891481 | ||
|
Protein |
aceE |
Experiment(s):EBI-884584 | ||
|
Protein |
agaI |
Experiment(s):EBI-884584 | ||
|
Protein |
yegL |
Experiment(s):EBI-884584 | ||
|
Protein |
clpA |
Experiment(s):EBI-884584 | ||
|
Protein |
dnaK |
Experiment(s):EBI-884584 | ||
|
Protein |
dsbG |
Experiment(s):EBI-884584 | ||
|
Protein |
greA |
Experiment(s):EBI-884584 | ||
|
Protein |
gyrA |
Experiment(s):EBI-884584 | ||
|
Protein |
hsdR |
Experiment(s):EBI-884584 | ||
|
Protein |
degP |
Experiment(s):EBI-884584 | ||
|
Protein |
lon |
Experiment(s):EBI-884584 | ||
|
Protein |
metK |
Experiment(s):EBI-884584 | ||
|
Protein |
rplE |
Experiment(s):EBI-884584 | ||
|
Protein |
ydiH |
Experiment(s):EBI-891481 | ||
|
Protein |
kefC |
Experiment(s):EBI-891481 | ||
|
Protein |
mtlA |
Experiment(s):EBI-891481 | ||
|
Protein |
rplA |
Experiment(s):EBI-891481 | ||
|
Protein |
rplC |
Experiment(s):EBI-891481 | ||
|
Protein |
rplD |
Experiment(s):EBI-891481 | ||
|
Protein |
rplL |
Experiment(s):EBI-891481 | ||
|
Protein |
rplU |
Experiment(s):EBI-891481 | ||
|
Protein |
rpmB |
Experiment(s):EBI-891481 | ||
|
Protein |
rpmC |
Experiment(s):EBI-891481 | ||
|
Protein |
rpmG |
Experiment(s):EBI-891481 | ||
|
Protein |
rpsB |
Experiment(s):EBI-891481 | ||
|
Protein |
rpsF |
Experiment(s):EBI-891481 | ||
|
Protein |
rpsP |
Experiment(s):EBI-891481 | ||
|
Protein |
ugpB |
Experiment(s):EBI-891481 | ||
|
Protein |
yfiF |
Experiment(s):EBI-891481 | ||
|
Protein |
yjgD |
Experiment(s):EBI-891481 | ||
|
Protein |
rplK |
Experiment(s):EBI-891481 | ||
|
Protein |
prs |
Experiment(s):EBI-1136626 | ||
|
Protein |
cheA |
Experiment(s):EBI-1136626 | ||
|
Protein |
yahN |
Experiment(s):EBI-1136626 | ||
|
Protein |
rhlE |
Experiment(s):EBI-1136626 | ||
|
Protein |
adk |
Experiment(s):EBI-1136626 | ||
|
Protein |
tig |
Experiment(s):EBI-1136626 | ||
|
Protein |
groL |
Experiment(s):EBI-1136626 | ||
|
Protein |
rho |
Experiment(s):EBI-1136626 | ||
|
Protein |
yehC |
Experiment(s):EBI-1136626 | ||
|
Protein |
clpX |
Experiment(s):EBI-1136626 | ||
|
Protein |
slyD |
Experiment(s):EBI-1136626 | ||
|
Protein |
mutL |
Experiment(s):EBI-1136626 | ||
|
Protein |
flgA |
Experiment(s):EBI-1136626 | ||
|
Protein |
tatE |
Experiment(s):EBI-1136626 | ||
|
Protein |
basR |
Experiment(s):EBI-1136626 | ||
|
Protein |
rnhA |
Experiment(s):EBI-1136626 | ||
|
Protein |
rhsE |
Experiment(s):EBI-1136626 | ||
|
Protein |
gfcD |
Experiment(s):EBI-1136626 | ||
|
Protein |
groL |
LCMS(ID Probability):99.6 MALDI(Z-score):17.053160 | ||
|
Protein |
rraB |
LCMS(ID Probability):99.0 | ||
|
Protein |
groS |
LCMS(ID Probability):99.0 MALDI(Z-score):17.053160 | ||
|
Protein |
rfaD |
LCMS(ID Probability):99.6 MALDI(Z-score):39.472640 | ||
|
Protein |
yegL |
MALDI(Z-score):17.053160 | ||
|
Protein |
ydiH |
LCMS(ID Probability):99.0 | ||
|
Protein |
degP |
MALDI(Z-score):17.053160 | ||
|
Protein |
kefC |
LCMS(ID Probability):99.0 | ||
|
Protein |
agaI |
MALDI(Z-score):17.053160 | ||
|
Protein |
mtlA |
LCMS(ID Probability):99.0 | ||
|
Protein |
Subunits of ClpAXP |
could be indirect |
||
|
Protein |
Subunits of ClpXP |
could be indirect |
||
|
Protein |
Subunits of ClpAP |
could be indirect |
| |
| edit table |
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Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
| edit table |
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Notes
Structure and Physical Properties
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Physical Properties
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MSYSGERDNF APHMALVPMV IEQTSRGERS FDIYSRLLKE RVIFLTGQVE DHMANLIVAQ MLFLEAENPE KDIYLYINSP GGVITAGMSI YDTMQFIKPD VSTICMGQAA SMGAFLLTAG AKGKRFCLPN SRVMIHQPLG GYQGQATDIE IHAREILKVK GRMNELMALH TGQSLEQIER DTERDRFLSA PEAVEYGLVD SILTHRN |
| Length |
207 |
| Mol. Wt |
23.186 kDa |
| pI |
5.5 (calculated) |
| Extinction coefficient |
10,430 - 10,680 (calc based on 7 Y, 0 W, and 2 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
| </protect>
Structure figures<protect> | ||||||
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
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Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
- ↑ Andresen, BS et al. (2000) Characterization of mouse Clpp protease cDNA, gene, and protein. Mamm. Genome 11 275-80 PubMed
- ↑ Chuang, SE & Blattner, FR (1993) Characterization of twenty-six new heat shock genes of Escherichia coli. J. Bacteriol. 175 5242-52 PubMed
- ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 8.24 8.25 8.26 8.27 8.28 8.29 8.30 8.31 8.32 8.33 8.34 8.35 8.36 8.37 8.38 8.39 8.40 8.41 8.42 8.43 8.44 8.45 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
- ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
- ↑ 10.0 10.1 10.2 10.3 10.4 10.5 10.6 10.7 10.8 10.9 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
- ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0000166 ! nucleotide binding
- GO:0004252 ! serine-type endopeptidase activity
- GO:0005524 ! ATP binding
- GO:0005829 ! cytosol
- GO:0006508 ! proteolysis
- GO:0006515 ! protein quality control for misfolded or incompletely synthesized proteins
- GO:0006950 ! response to stress
- GO:0008233 ! peptidase activity
- GO:0009408 ! response to heat
- GO:0008236 ! serine-type peptidase activity
- GO:0016020 ! membrane
- GO:0016787 ! hydrolase activity
- Proteins
