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Description (originally from EcoCyc[1]) ClpAXP

Comments (originally from EcoCyc[1]) Hybrid complexes can form in vitro, consisting of a ClpP tetradecamer capped at one end with ClpA and at the other with ClpX. These complexes are translocation competent. Stoichiometry in vivo suggests heterocomplexes may form there, as well [2].


  1. 1.0 1.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. Ortega, J et al. () ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes. J. Struct. Biol. 146 217-26 PubMed

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