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Gene |

Product(s) |

Expression|

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References |

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Standard Name	atpB
Gene Synonym(s)	ECK3731, b3738, JW3716, papD, uncB^[1], uncB
Product Desc.	ATP synthase, F0 complex, a subunit^[2]^[3]; Component of ATP synthase, F0 complex^[2]^[3]; ATP synthase^[2]^[3] ATP synthase subunit a, membrane-bound, F0 sector^[4]
Product Synonyms(s)	F0 sector of membrane-bound ATP synthase, subunit a^[1], B3738^[2]^[1], UncB^[2]^[1], PapD^[2]^[1], AtpB^[2]^[1], protein 6^[2]^[1], chain A^[2]^[1] , ECK3731, JW3716, papD, uncB, b3738
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): atpBEFHAGDC^[2], atpIBEFHAGDC^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	atpB
Mnemonic	ATP
Synonyms	ECK3731, b3738, JW3716, papD, uncB^[1], uncB
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	84.47 minutes	MG1655: 3920074..3919259 <gbrowseImage> name=NC_000913:3919259..3920074 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3882417..3881602 <gbrowseImage> name=NC_012967:3881602..3882417 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3807592..3808407 <gbrowseImage> name=NC_012759:3807592..3808407 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3714630..3715445 <gbrowseImage> name=NC_007779:3714630..3715445 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4017658..4016843 <gbrowseImage> name=NC_010473:4016843..4017658 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Description	Reference	Availability	Comments
atpBS206L		S206L	Reduced activity			seeded from UniProt:P0AB98
atpBL207Y,F		L207Y,F	No change in activity			seeded from UniProt:P0AB98
atpBR210K,I,V,E		R210K,I,V,E	Completely defective			seeded from UniProt:P0AB98
atpBA217R		A217R	Completely defective			seeded from UniProt:P0AB98
atpBH245Y		H245Y	Reduced activity			seeded from UniProt:P0AB98
atpBA217H		A217H	Reduced activity			seeded from UniProt:P0AB98
atpBN214V		N214V	Reduced activity			seeded from UniProt:P0AB98
atpBN214H		N214H	Completely defective			seeded from UniProt:P0AB98
ΔatpB (Keio:JW3716)	deletion	deletion		PMID:16738554	Shigen CGSC10717^[5]
atpB402					CGSC:7158
ΔatpB767::kan				PMID:16738554	CGSC:100136
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW3716	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGCTTCAGAAAATATGACGCC Primer 2:CCATGTTCTTCAGACGCCATCGA
2A1	Kohara Phage	Genobase	PMID:3038334
zid-501::Tn10	Linked marker	CAG18499 = CGSC7458^[5]	est. P1 cotransduction: 14% ^[6]
rbsD296::Tn10	Linked marker	CAG18501 = CGSC7460^[5]	est. P1 cotransduction: 70% ^[6] Synonyms:zie-296::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10099	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10099	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000095	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948252	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0097	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012222	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	AtpB
Synonyms	F0 sector of membrane-bound ATP synthase, subunit a^[1], B3738^[2]^[1], UncB^[2]^[1], PapD^[2]^[1], AtpB^[2]^[1], protein 6^[2]^[1], chain A^[2]^[1] , ECK3731, JW3716, papD, uncB, b3738
Product description	ATP synthase, F0 complex, a subunit^[2]^[3]; Component of ATP synthase, F0 complex^[2]^[3]; ATP synthase^[2]^[3] ATP synthase subunit a, membrane-bound, F0 sector^[4]
EC number (for enzymes)	3.6.3.14^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016021	integral to membrane	PMID:2863271	IDA: Inferred from Direct Assay		C	Seeded from Riley et al 2006 ^[1].	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
Contributes to	GO:0046961	proton-transporting ATPase activity, rotational mechanism	PMID:2863271	IMP: Inferred from Mutant Phenotype		F		complete
	GO:0015078	hydrogen ion transmembrane transporter activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000568	F	Seeded from EcoCyc (v14.0)	complete
	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	PMID:6460031	IMP: Inferred from Mutant Phenotype		C		complete
	GO:0015986	ATP synthesis coupled proton transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000568	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9909	C	Seeded from EcoCyc (v14.0)	complete
	GO:0042777	plasma membrane ATP synthesis coupled proton transport	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01393	P	Seeded from EcoCyc (v14.0)	complete
	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000568	C	Seeded from EcoCyc (v14.0)	complete
	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0138	C	Seeded from EcoCyc (v14.0)	complete
	GO:0046933	hydrogen ion transporting ATP synthase activity, rotational mechanism	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01393	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes
Protein	Subunits of ATP synthase, F0 complex	could be indirect
Protein	Subunits of ATP synthase	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
plasma membrane	C-terminus localized in the cytoplasm with 5 predicted transmembrane domains	Daley et al. (2005) ^[7]
plasma membrane			From EcoCyc^[3]
Inner membrane		PMID:10806384	EchoLocation:atpB	Integral Membrane Protein
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MASENMTPQD YIGHHLNNLQ LDLRTFSLVD PQNPPATFWT INIDSMFFSV VLGLLFLVLF RSVAKKATSG VPGKFQTAIE LVIGFVNGSV KDMYHGKSKL IAPLALTIFV WVFLMNLMDL LPIDLLPYIA EHVLGLPALR VVPSADVNVT LSMALGVFIL ILFYSIKMKG IGGFTKELTL QPFNHWAFIP VNLILEGVSL LSKPVSLGLR LFGNMYAGEL IFILIAGLLP WWSQWILNVP WAIFHILIIT LQAFIFMVLT IVYLSMASEE H
Length	271
Mol. Wt	30.304 kDa
pI	6.8 (calculated)
Extinction coefficient	47,440 (calc based on 6 Y, 7 W, and 0 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	39..266	PF00119 ATP synthase A chain		PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=atpB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131606	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948252	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012222	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0AB98	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10099	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10099	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948252	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000095	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0097	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	10508	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	3471	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	4701	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
atpBEFHAGDC
atpIBEFHAGDC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3920054..3920094 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

</protect>

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3738 (EcoliWiki Page)	NCBI GEO profiles for atpB
microarray	GenExpDB:b3738 (EcoliWiki Page)	Summary of data for atpB from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to atpB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10099	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0097	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3738
EcoGene	EcoGene:EG10099	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000095	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012222	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000023228 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT2G07741 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-011205-18 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0201600 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000028436 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000354632 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q36271 (score: 1.000; bootstrap: 57%) Q35782 (score: 0.555) Q6R982 (score: 0.517) P07925 (score: 0.517) Q35781 (score: 0.504) Q8HCP2 (score: 0.492) P68527 (score: 0.481) P68526 (score: 0.481) Q8S1Q3 (score: 0.444) Q37807 (score: 0.444) Q36986 (score: 0.444) O21786 (score: 0.444) Q36747 (score: 0.392)	From Inparanoid:20070104
Saccharomyces cerevisiae	Q0085 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPMIT7 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000013970 (score: 1.000; bootstrap: 96%)	From Inparanoid:20070104
Shigella flexneri	ATPB	From SHIGELLACYC
E. coli O157	ATPB	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00119 ATP synthase A chain
Panther (EcoliWiki Page)	PTHR11410:SF0
Superfamily (EcoliWiki Page)	SUPERFAMILY:81336
EcoCyc	EcoCyc:EG10099	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10099	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000095	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0097	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012222	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 ^1.16 ^1.17 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 ^2.15 ^2.16 ^2.17 ^2.18 ^2.19 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

atpB:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to atpB Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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