acpT:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

AcpT

Synonyms

holo-(acyl carrier protein) synthase 2[1], B3475[2][1], YhhU[2][1], AcpT[2][1] , ECK3459, JW3440, yhhU, b3475

Product description

holo-[acyl carrier protein] synthase 2[2][3]

CoA-phosphopantetheinyltransferase; native apo-protein substrate unknown, possibly a back-up gene for acpS; multicopy suppressor of acpS1, can modify ACP when overexpressed[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0005737

cytoplasm

C

Seeded from Riley et al 2006 [1].

Missing: evidence, reference

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

F

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

F

Seeded from EcoCyc (v14.0)

complete

GO:0009059

macromolecule biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR008278

P

Seeded from EcoCyc (v14.0)

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

PMID:16824108[5]

IDA: Inferred from Direct Assay

F

complete

GO:0005625

soluble fraction

PMID:16824108[5]

IDA: Inferred from Direct Assay

C

complete

GO:0018070

peptidyl-serine phosphopantetheinylation

PMID:8939709[6]

NAS: Non-traceable Author Statement

P

complete

GO:0008897

holo-(acyl-carrier-protein) synthase activity

PMID:16824108[5]

IMP: Inferred from Mutant Phenotype

F

Substrate is Z4853 from e. coli 0157:H7, Figure 3.

complete

GO:0006633

fatty acid biosynthetic process

PMID:10625633[7]

IGI: Inferred from Genetic Interaction

EcoliWiki:acpS


P

Fig. 1

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MYRIVLGKVS TLSAAPLPPG LREQAPQGPR RERWLAGRAL LSHTLSPLPE IIYGEQGKPA
FAPEMPLWFN LSHSGDDIAL LLSDEGEVGC DIEVIRPRAN WRWLANAVFS LGEHAEMDAV
HPDQQLEMFW RIWTRKEAIV KQRGGSAWQI VSVDSTYHSS LSVSHCQLEN LSLAICTPTP
FTLTADSVQW IDSVN
Length

195

Mol. Wt

21.767 kDa

pI

5.7 (calculated)

Extinction coefficient

48,470 - 48,845 (calc based on 3 Y, 8 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

88..151

PF01648 4'-phosphopantetheinyl transferase superfamily

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=acpT taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131347

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:947979

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011351

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P37623

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG12221

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG12221

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:947979

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120002107

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB2135

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 De Lay, NR & Cronan, JE (2006) A genome rearrangement has orphaned the Escherichia coli K-12 AcpT phosphopantetheinyl transferase from its cognate Escherichia coli O157:H7 substrates. Mol. Microbiol. 61 232-42 PubMed
  6. ↑ Lambalot, RH et al. (1996) A new enzyme superfamily - the phosphopantetheinyl transferases. Chem. Biol. 3 923-36 PubMed
  7. ↑ Flugel, RS et al. (2000) Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J. Biol. Chem. 275 959-68 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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