PMID:8939709
| Citation |
Lambalot, RH, Gehring, AM, Flugel, RS, Zuber, P, LaCelle, M, Marahiel, MA, Reid, R, Khosla, C and Walsh, CT (1996) A new enzyme superfamily - the phosphopantetheinyl transferases. Chem. Biol. 3:923-36 |
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| Abstract |
All polyketide synthases, fatty acid synthases, and non-ribosomal peptide synthetases require posttranslational modification of their constituent acyl carrier protein domain(s) to become catalytically active. The inactive apoproteins are converted to their active holo-forms by posttranslational transfer of the 4'-phosphopantetheinyl (P-pant) moiety of coenzyme A to the sidechain hydroxyl of a conserved serine residue in each acyl carrier protein domain. The first P-pant transferase to be cloned and characterized was the recently reported Escherichia coli enzyme ACPS, responsible for apo to holo conversion of fatty acid synthase. Surprisingly, initial searches of sequence databases did not reveal any proteins with significant peptide sequence similarity with ACPS. |
| Links | |
| Keywords |
Amino Acid Sequence; Molecular Sequence Data; Sequence Homology, Amino Acid; Substrate Specificity; Transferases/chemistry; Transferases/metabolism; Valine/metabolism |
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