mutL:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Structure Resources Accessions Links References Suggestions

Nomenclature

Standard name

MutL product

Synonyms

methyl-directed mismatch repair protein product[1], B4170 product[2][1], MutL product[2][1]

Product description

MutL[2][3];

Component of ; MutHLS complex, methyl-directed mismatch repair[2][3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0005524

ATP_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

PMID:9827806[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc 12.5 [4]

GO:0000166

nucleotide_binding

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc 12.5 [4]

GO:0005515

protein_binding

PMID:15690043[6]

IPI: Inferred from Physical Interaction

UniProtKB:P0A6N1

F

Seeded from EcoCyc 12.5 [4]

GO:0005515

protein_binding

PMID:9482750[7]

IPI: Inferred from Physical Interaction

UniProtKB:P03018

F

Seeded from EcoCyc 12.5 [4]

GO:0005515

protein_binding

PMID:9880500[8]

IPI: Inferred from Physical Interaction

UniProtKB:P06722

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002099

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003594

F

Seeded from EcoCyc 12.5 [4]

GO:0005524

ATP_binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013507

F

Seeded from EcoCyc 12.5 [4]

GO:0006281

DNA_repair

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded from EcoCyc 12.5 [4]

GO:0005737

cytoplasm

C

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0006298

mismatch repair

PMID:6987663[9]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0005524

ATP binding

PMID:9827806[5]

IDA: Inferred from Direct Assay

F

complete

GO:0006298

mismatch repair

PMID:2665076[10]

IDA: Inferred from Direct Assay

P

complete

GO:0032300

mismatch repair complex

PMID:6987663[9]

IGI: Inferred from Genetic Interaction

UniProtKB:P06722|UniProtKB:P23909

C

With MutH (P06722) and MutS (P23909).

complete

GO:0016887

ATPase activity

PMID:9827806[5]

IDA: Inferred from Direct Assay

F

complete

GO:0016887

ATPase activity

PMID:9827806[5]

IMP: Inferred from Mutant Phenotype

F

complete

GO:0006298

mismatch_repair

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00149

P

Seeded from EcoCyc 12.5 [4]


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Interactions

Partner Type Partner Notes

Protein

Subunits of MutHLS complex, methyl-directed mismatch repair

Inferred from genetic interaction [9]

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Notes

Localization

Compartment Description Evidence Notes
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Notes

Structure and Physical Properties

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Physical Properties

Sequence

at EcoCyc 

MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG
CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA
WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL
ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV
ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD
VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR
NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA
PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC
AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP
ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL
QSVDLHPAIK ALKDE
Mol. Wt

67.92 kDa (calc) [2]

pI
Extinction coefficient

54890 - 55765 (calc based on 11 Y, 7 W, and 7 C residues)

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Domains/Motifs/Modification Sites

Type Residues Description Notes
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Structure

Structure Type Organism Accession Residues covered Notes

X-RAY DIFFRACTION

Escherichia coli

1BKN CRYSTAL STRUCTURE OF AN N-TERMINAL 40KD FRAGMENT OF E. COLI DNA MISMATCH REPAIR PROTEIN MUTL

X-RAY DIFFRACTION

Escherichia coli

1B63 MUTL COMPLEXED WITH ADPNP

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Notes

Gene Product Resources

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Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG11281-MONOMER

UniProt (EcoliWiki Page)

UniProt:P23367

PFAM (EcoliWiki Page)

PFAM:PF02518

RefSeq (EcoliWiki Page)

RefSeq:NP_418591

ModBase (EcoliWiki Page)

ModBase:P23367

PDB (EcoliWiki Page)

PDB:1B63

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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  5. ↑ 5.0 5.1 5.2 5.3 Ban, C & Yang, W (1998) Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95 541-52 PubMed
  6. ↑ Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  7. ↑ Hall, MC et al. (1998) Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17 1535-41 PubMed
  8. ↑ Hall, MC & Matson, SW (1999) The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity. J. Biol. Chem. 274 1306-12 PubMed
  9. ↑ 9.0 9.1 9.2 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed
  10. ↑ Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed


Categories

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