mutL:Gene Product(s): Difference between revisions
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IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
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F | |||
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complete | |||
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GO:0016887 | |||
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ATPase activity | |||
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[[PMID:9827806]]<ref name=PMID:9827806/> | |||
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IMP: Inferred from Mutant Phenotype | |||
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Revision as of 23:00, 1 November 2007
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
MutL product |
|---|---|
| Synonyms |
methyl-directed mismatch repair protein product[1], B4170 product[2][1], MutL product[2][1] |
| Product description |
Component of ; MutHLS complex, methyl-directed mismatch repair[2][3] |
| EC number (for enzymes) |
|
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See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Notes
Function
Gene Ontology
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0006281 |
DNA repair |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0005737 |
cytoplasm |
C |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0006298 |
mismatch repair |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
| GO:0005524 |
ATP binding |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0006298 |
mismatch repair |
IDA: Inferred from Direct Assay |
P |
complete | ||||
| GO:0032300 |
mismatch repair complex |
IGI: Inferred from Genetic Interaction |
MutH and MutS |
C |
complete | |||
| GO:0016887 |
ATPase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0016887 |
ATPase activity |
IMP: Inferred from Mutant Phenotype |
F |
complete | ||||
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See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
Interactions
| Partner Type | Partner | Notes |
|---|---|---|
|
Protein |
Subunits of MutHLS complex, methyl-directed mismatch repair |
Inferred from genetic interaction [4] |
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See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Notes
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
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See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL QSVDLHPAIK ALKDE |
|---|---|
| Mol. Wt |
67.92 kDa (calc) [2] |
| pI | |
| Extinction coefficient |
54890 - 55765 (calc based on 11 Y, 7 W, and 7 C residues) |
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See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
| edit table |
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
Structure
| Structure Type | Organism | Accession | Residues covered | Notes |
|---|---|---|---|---|
|
X-RAY DIFFRACTION |
Escherichia coli |
1BKN CRYSTAL STRUCTURE OF AN N-TERMINAL 40KD FRAGMENT OF E. COLI DNA MISMATCH REPAIR PROTEIN MUTL |
||
|
X-RAY DIFFRACTION |
Escherichia coli |
1B63 MUTL COMPLEXED WITH ADPNP |
||
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See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
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See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 4.2 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed
- ↑ 5.0 5.1 5.2 Ban, C & Yang, W (1998) Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95 541-52 PubMed
- ↑ Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed
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