ftsK:Gene: Difference between revisions

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!align=left |Standard name
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''ftsK''  
''ftsK''
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!align=left |Mnemonic
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filamentation temperature sensitive
filamentation temperature sensitive
Filamentation, temperature sensitive
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!align=left |Synonyms
!align=left {{table_heading_style}} |Synonyms
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''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>
''ECK0881, b0890, JW0873, dinH''<ref name='LIB:Riley_2006'/>
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!|Strain!!Map location!!Genome coordinates!!Genome browsers!!Sequence links
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Carries a deletion of FtsK <sub>L</sub> and FtsK <sub>C</sub>  
Carries a deletion of FtsK <sub>L</sub> and FtsK <sub>C</sub>  
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ftsKG80A
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G80A
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In Toe44; loss of function under extreme conditions
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seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]
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ftsKG80A
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G80A
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In Toe44; loss of function under extreme conditions
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seeded from [http://www.uniprot.org/uniprot/P46889 UniProt:P46889]


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Revision as of 21:12, 25 February 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Location(s) and DNA Sequence Alleles and Phenotypes Genetic Resources Accessions Links References Suggestions

Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

ftsK

Mnemonic

filamentation temperature sensitive Filamentation, temperature sensitive

Synonyms

ECK0881, b0890, JW0873, dinH[1]

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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

MG1655

20.1 minutes 

MG1655: 932447..936436
gbrowse_img.php?coord=932447..936436&genome=ecoli&name=MG1655&trackset=0&width=300&.png

REL606

NC_012967: 950282..954310
gbrowse_img.php?coord=950282..954310&genome=REL606&name=NC_012967&trackset=0&width=300&.png

W3110

 

W3110: 933646..937635
gbrowse_img.php?coord=933646..937635&genome=ecoli_W3110&name=W3110&trackset=0&width=300&.png

DH10B

DH10B: 986375..990364
gbrowse_img.php?coord=986375..990364&genome=ecoli_DH10B&name=DH10B&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature type Location Description
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

ΔLC

PMID:15522074[2]

Carries a deletion of FtsK L and FtsK C

ftsKG80A

G80A

In Toe44; loss of function under extreme conditions

seeded from UniProt:P46889

ftsKE58A

E58A

Loss of function

seeded from UniProt:P46889

NC

PMID:15522074[2]

Barre

Deletion of the FtsK Linker

NL hi C

PMID:15522074[2]

Barre

Carries swaps b/t E.coli and H. influenzae FtsK regions

ftsK A

K997A

PMID:15522074[2]

Barre

Carries a single point mutation in the walker A motif of FtsK C

NLC hi

PMID:15522074[2]

Barre

Carries swaps b/t E.coli and H.influenzae FtsK regions

ftsk::cat1

PMID:9721304[3]

Donachie Sheratt

only expresses the NTD due to a Cm resistance cassette at nt 678 of ftsK

ftsk44

Growth Phenotype

temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

PMID:7592387[4]

Donachie

ftsK1::cat

Other

chromosome segregation

defect in the C-terminus of FtsK

ftsK1::cat ΔmukB

Growth Phenotype

synthetically lethal

PMID:9829960[6]

shown that it must be complemented in trans

ftsK::cat-2

Δ54-2201

PMID:9721304[3]

almost the entire N-terminal membrane-spanning domain is deleted, and the C-terminal fragment is out of frame with the cat gene. Lethal- must be complemented in trans

ftsK::cat-Δ5

Δ54-3651

PMID:9721304[3]

this is a deletion of 90% of ftsK

ftsK3531

missense mutation

Growth Phenotype

same phenotype as ftsK44- temperature sensitive late stage block in division, but does not affect chromosome replication or segregation

PMID:9721304[3]

ftsK::cat-Δ2 ΔdacA::kan

Cell Shape

  • forms small colonies on plates grows well
  • produces a population of misshapen cells in liquid culture

PMID:9721304[3]

ftsK::cat-Δ5 Δdac::kan

Other

synthetically lethal

PMID:9721304[3]


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Notes

Deletions that leave the membrane segments intact are viable.[7]

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference

JW0873

Plasmid clone

Shigen

PMID:16769691[8]

Status:Clone OK

Primer 1:GCCAGCCAGGAATACATTGAAGA

Primer 2:CCGTCAAACGGCGGTGGGGCCAG

zbh-29::Tn10

Linked marker

CAG18493 = CGSC7353[9]

est. P1 cotransduction: % [10]
Synonyms:zbi-29::Tn10

zca-1230::Tn10

Linked marker

CAG18478 = CGSC7356[9]

est. P1 cotransduction: 61% [10]
Synonyms:zbj-1230::Tn10

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:G6464

EchoBASE (EcoliWiki Page)

EchoBASE:EB3016

EcoliGenExpDB (EcoliWiki Page)

EcoliGenExpDB:b0890

ECOL199310CYC (EcoliWiki Page)

ECOL199310CYC:C1027

EcoGene (EcoliWiki Page)

EcoGene:EG13226

ECOO157CYC (EcoliWiki Page)

ECOO157CYC:FTSK

ASAP (EcoliWikiPage)

ASAP:ABE-0003027


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Notes

Links

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<protect>

References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Bigot, S et al. (2004) FtsK activities in Xer recombination, DNA mobilization and cell division involve overlapping and separate domains of the protein. Mol. Microbiol. 54 876-86 PubMed
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Draper, GC et al. (1998) Only the N-terminal domain of FtsK functions in cell division. J. Bacteriol. 180 4621-7 PubMed
  4. ↑ Begg, KJ et al. (1995) A new Escherichia coli cell division gene, ftsK. J. Bacteriol. 177 6211-22 PubMed
  5. ↑ Diez, AA et al. (1997) A mutation in the ftsK gene of Escherichia coli affects cell-cell separation, stationary-phase survival, stress adaptation, and expression of the gene encoding the stress protein UspA. J. Bacteriol. 179 5878-83 PubMed
  6. ↑ 6.0 6.1 Yu, XC et al. (1998) Role of the C terminus of FtsK in Escherichia coli chromosome segregation. J. Bacteriol. 180 6424-8 PubMed
  7. ↑ Draper, GC et al. (1998) Only the N-terminal domain of FtsK functions in cell division. J. Bacteriol. 180 4621-7 PubMed
  8. ↑ Kitagawa, M et al. (2005) Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. DNA Res. 12 291-9 PubMed
  9. ↑ 9.0 9.1 CGSC: The Coli Genetics Stock Center
  10. ↑ 10.0 10.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

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