mutL:Gene Product(s): Difference between revisions

Standard name	MutL
Synonyms	methyl-directed mismatch repair protein^[1], B4170^[2]^[1], MutL^[2]^[1] , ECK4166, JW4128, b4170
Product description	MutL^[2]^[3]; Component of MutHLS complex, methyl-directed mismatch repair^[2]^[3] Methyl-directed mismatch repair; matchmaker protein; weak DNA-stimulated ATPase^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006298	mismatch repair	PMID:6987663^[5]	IMP: Inferred from Mutant Phenotype		P		complete
	GO:0005524	ATP binding	PMID:9827806^[6]	IDA: Inferred from Direct Assay		F		complete
	GO:0006298	mismatch repair	PMID:2665076^[7]	IDA: Inferred from Direct Assay		P		complete
	GO:0032300	mismatch repair complex	PMID:6987663^[5]	IGI: Inferred from Genetic Interaction	UniProtKB:P06722\|UniProtKB:P23909	C	With MutH (P06722) and MutS (P23909).	complete
	GO:0005515	protein binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020667	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016887	ATPase activity	PMID:9827806^[6]	IDA: Inferred from Direct Assay		F		complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002099	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016887	ATPase activity	PMID:9827806^[6]	IMP: Inferred from Mutant Phenotype		F		complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003594	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013507	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0006298	mismatch repair	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00149	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006298	mismatch repair	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002099	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006298	mismatch repair	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013507	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006298	mismatch repair	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR020667	P	Seeded from EcoCyc (v14.0)	complete
	GO:0030983	mismatched DNA binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002099	F	Seeded from EcoCyc (v14.0)	complete
	GO:0030983	mismatched DNA binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013507	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	PMID:12606120^[8]	IDA: Inferred from Direct Assay		F		complete
	GO:0003677	DNA binding	PMID:12606120^[8]	IDA: Inferred from Direct Assay		F		complete
	GO:0016887	ATPase activity	PMID:9827806^[6]	IDA: Inferred from Direct Assay		F		complete
	GO:0005524	ATP binding	PMID:9827806^[6]	IDA: Inferred from Direct Assay		F		complete
	GO:0000018	regulation of DNA recombination	PMID:2555716^[9]	IMP: Inferred from Mutant Phenotype		P		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of MutHLS complex, methyl-directed mismatch repair		PMID:6987663^[5]	Inferred from genetic interaction
Protein	tufA		PMID:15690043^[10]	Experiment(s):EBI-880976
Protein	dnaK		PMID:15690043^[10]	Experiment(s):EBI-887579
Protein	rpsA		PMID:15690043^[10]	Experiment(s):EBI-887579
Protein	rpsA		PMID:19402753^[11]	LCMS(ID Probability):99.6
Protein	Vsr		PMID:19376855^[12]
Protein	DnaN: beta sliding clamp of DNA Pol III	MutL only binds to the beta subunit in the presence of ss DNA.	PMID:16546997^[13]	native gel electrophoresis
Protein	MutH	data suggest the ATPase fragment of MutL directly contacts MutH	PMID:9827806^[6]	Chemical crosslinking
Protein	MutS		PMID:9250691^[14]	Visualized using EM
Protein	UvrD		PMID:9880500^[15]	2-Hybrid Screen
Protein	MutH	The C-terminal 218 amino acids of MutL were sufficient for the two-hybrid interaction with MutH	PMID:9880500^[15]	2 Hybrid Screen
Protein	UvrD	Both the N- and C-termini of UvrD were required for interaction with MutL	PMID:9482750^[16]	2 Hybrid Screen
Protein	RecA	The N-terminal fragment of MutL (residues 1-349) was sufficient to bind RecA. MutL inhibits the ssDNA-dependent ATPase activity of RecA (Fig. 4)	PMID:22001225^[17]	Far-Western and pull-down assays.
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MPIQVLPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIDIERGG AKLIRIRDNG CGIKKDELAL ALARHATSKI ASLDDLEAII SLGFRGEALA SISSVSRLTL TSRTAEQQEA WQAYAEGRDM NVTVKPAAHP VGTTLEVLDL FYNTPARRKF LRTEKTEFNH IDEIIRRIAL ARFDVTINLS HNGKIVRQYR AVPEGGQKER RLGAICGTAF LEQALAIEWQ HGDLTLRGWV ADPNHTTPAL AEIQYCYVNG RMMRDRLINH AIRQACEDKL GADQQPAFVL YLEIDPHQVD VNVHPAKHEV RFHQSRLVHD FIYQGVLSVL QQQLETPLPL DDEPQPAPRS IPENRVAAGR NHFAEPAARE PVAPRYTPAP ASGSRPAAPW PNAQPGYQKQ QGEVYRQLLQ TPAPMQKLKA PEPQEPALAA NSQSFGRVLT IVHSDCALLE RDGNISLLSL PVAERWLRQA QLTPGEAPVC AQPLLIPLRL KVSAEEKSAL EKAQSALAEL GIDFQSDAQH VTIRAVPLPL RQQNLQILIP ELIGYLAKQS VFEPGNIAQW IARNLMSEHA QWSMAQAITL LADVERLCPQ LVKTPPGGLL QSVDLHPAIK ALKDE
Length	615
Mol. Wt	67.924 kDa
pI	6.8 (calculated)
Extinction coefficient	54,890 - 55,765 (calc based on 11 Y, 7 W, and 7 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	18..147	PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	PMID:19920124^[18]
Domain	212..331	PF01119 DNA mismatch repair protein, C-terminal domain	PMID:19920124^[18]
Domain	434..576	PF08676 MutL C terminal dimerisation domain	PMID:19920124^[18]
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mutL taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
Purified protein	MutL R266E^[8]	Behaves like ΔmutL Reduced DNA binding activity Is completely inactive in MMR and in blocking homologous recombination in vivo Activates MutH ~50% better than wt MutL Basal level ATPase activity similar to wt MutL, which no longer responds to DNA stimulation
Purified protein	MutL R95F^[8]	Mildly defective ATPase activity Defective MutH activation in vitro Moderately elevated mutation and DNA recombination rates in vivo
Purified protein	MutL N302A^[8]	Mildly defective ATPase activity Defective MutH activation in vitro Moderately elevated mutation and DNA recombination rates in vivo
Purified protein	MutL R261H^[8]	Reduced ATP binding Exhibit a 20-80% reduction in the ATP-dependent activation of MutH endonuclease activity
Purified protein	MutL K307A^[8]	Reduced ATP binding Exhibit a 20-80% reduction in the ATP-dependent activation of MutH endonuclease activity
Purified protein	MutL E29A^[8]	Binds ATP well, but hydrolyzes it poorly Activates MutH well, but fails to mediate the mismatch-dependent MutH activation by MutS in the MMR initiation assays
Purified protein	MutL R95F/N302A^[8]	Binds ATP well, but hydrolyzes it poorly Activates MutH well, but fails to mediate the mismatch-dependent MutH activation by MutS in the MMR initiation assays
Purified protein	MutL I90R^[8]	Behave like wt MutL in vitro and in vivo
Purified protein	MutL I90E^[8]	Behave like wt MutL in vitro and in vivo
Purified protein	MutL R237E^[8]	Behave like wt MutL in vitro and in vivo
Purified protein	MutL G238A^[8]	Appears to have no in vivo defect Insolubility issues prevented in vitro assays
Purified protein	MutL K159E^[8]	Alters the residues around the DNA binding cleft ~10-fold reduction in ATP hydrolysis Defective in DNA binding Fails to activate MMR and block homologous recombination
Purified protein	MutL G238D^[8]	Confers a dominant mutator phenotype Insolubility issues prevented in vitro assays
Purified protein	MutL R177E^[8]	Alters the residues around the DNA binding cleft Exhibits reduced catalytic efficiency Mediates the mismatch-dependent activation of MutH in vitro Exhibits a mutator phenotype and increased homologous recombination in vivo
Purification protocol	Single-step purification of His6-MutL	PMID:8747662^[19]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131992	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948691	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0013655	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P23367	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11281	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11281	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948691	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001254	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1258	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 Glickman, BW & Radman, M (1980) Escherichia coli mutator mutants deficient in methylation-instructed DNA mismatch correction. Proc. Natl. Acad. Sci. U.S.A. 77 1063-7 PubMed
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Ban, C & Yang, W (1998) Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Cell 95 541-52 PubMed
↑ Lahue, RS et al. (1989) DNA mismatch correction in a defined system. Science 245 160-4 PubMed
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 ^8.11 ^8.12 ^8.13 ^8.14 ^8.15 Junop, MS et al. (2003) In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. DNA Repair (Amst.) 2 387-405 PubMed
↑ Rayssiguier, C et al. (1989) The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants. Nature 342 396-401 PubMed
↑ ^10.0 ^10.1 ^10.2 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
↑ Polosina, YY et al. (2009) The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage. J. Bacteriol. 191 4041-3 PubMed
↑ López de Saro, FJ et al. (2006) The beta sliding clamp binds to multiple sites within MutL and MutS. J. Biol. Chem. 281 14340-9 PubMed
↑ Allen, DJ et al. (1997) MutS mediates heteroduplex loop formation by a translocation mechanism. EMBO J. 16 4467-76 PubMed
↑ ^15.0 ^15.1 Hall, MC & Matson, SW (1999) The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity. J. Biol. Chem. 274 1306-12 PubMed
↑ Hall, MC et al. (1998) Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17 1535-41 PubMed
↑ Zhang, M et al. (2012) MutL associates with Escherichia coli RecA and inhibits its ATPase activity. Arch. Biochem. Biophys. 517 98-103 PubMed
↑ ^18.0 ^18.1 ^18.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
↑ Feng, G & Winkler, ME (1995) Single-step purifications of His6-MutH, His6-MutL and His6-MutS repair proteins of escherichia coli K-12. BioTechniques 19 956-65 PubMed

mutL:Gene Product(s): Difference between revisions

Latest revision as of 21:13, 17 February 2015

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

Navigation menu

@@ Line 44: / Line 44: @@
 !align=left {{table heading style}} |Synonyms
 ||
-methyl-directed mismatch repair protein<ref name='LIB:Riley_2006'/>, B4170<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MutL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>
+''methyl-directed mismatch repair protein<ref name='LIB:Riley_2006'/>, B4170<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MutL<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK4166, JW4128, b4170''
 |-
 !align=left {{table heading style}} |Product description
@@ Line 77: / Line 77: @@
 *
 ****************************************************************************************** -->{{Product_GO_help}}
-{| {{Prettytable}}  id="D46ab2298c363d"  class=" tableEdit GO_table_product dataTable"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="D46ab2298c363d"  class=" tableEdit GO_table_product dataTable"
 |- {{table_heading_style}}
-!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
+!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
 |-
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@@ Line 107: / Line 107: @@
 ATP binding
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 PMID:9827806
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 IDA: Inferred from Direct Assay
@@ Line 475: / Line 475: @@
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 F
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+complete
+|-
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+GO:0000018
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+regulation of DNA recombination
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+PMID:2555716
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+IMP: Inferred from Mutant Phenotype
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+P
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@@ Line 493: / Line 512: @@
 *
 ****************************************************************************************** -->{{Product_interactions_help}}
-{| {{Prettytable}}  id="Y46ab22a0bb494"  class=" tableEdit Product_interactions_table dataTable"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="Y46ab22a0bb494"  class=" tableEdit Product_interactions_table dataTable"
 |- {{table heading style}}
 !|Partner Type!!Partner!!Notes!!References!!Evidence
@@ Line 540: / Line 559: @@
 |
 Experiment(s):EBI-887579<br />
+|-
+|
+Protein
+|
+rpsA
+|
+|
+PMID:19402753
+|
+LCMS(ID Probability):99.6
 |-
 |
@@ Line 573: / Line 603: @@
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 Chemical crosslinking
+|-
+|
+Protein
+|
+MutS
+|
+|
+PMID:9250691
+|
+Visualized using EM
+|-
+|
+Protein
+|
+UvrD
+|
+|
+PMID:9880500
+|
+-Hybrid Screen
+|-
+|
+Protein
+|
+MutH
+|
+The C-terminal 218 amino acids of MutL were sufficient for the two-hybrid interaction with MutH
+|
+PMID:9880500
+|
+Hybrid Screen
+|-
+|
+Protein
+|
+UvrD
+|
+Both the N- and C-termini of UvrD were required for interaction with MutL
+|
+PMID:9482750
+|
+Hybrid Screen
+|-
+|
+Protein
+|
+[[recA:Gene_Product(s)|RecA]]
+|
+The N-terminal fragment of MutL (residues 1-349) was sufficient to bind RecA.
+MutL inhibits the ssDNA-dependent ATPase activity of RecA (Fig. 4)
+|
+PMID:22001225
+|
+Far-Western and pull-down assays.
 |- class="tableEdit_footer"
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 *
 ****************************************************************************************** -->{{Product_localization_help}}
-{|   id="F46ab22a21f17a"  class=" tableEdit Product_localization_table"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="F46ab22a21f17a"  class=" tableEdit Product_localization_table"
 |- {{table heading style}}
-!|Compartment!!Description!!Evidence!!Source!!Notes
+!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
 |- class="tableEdit_footer"
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 ****************************************************************************************** -->{{Product_physical_properties_help}}
 {|   id="K46ab22a35502c"  class=" tableEdit Product_phys_prop_table"
+|-
+!align=left {{table heading style}} |Name
+||
 |-
@@ Line 665: / Line 756: @@
 *
 ****************************************************************************************** -->{{Product_domains_motifs_help}}
-{|   id="V46ab22a3cfb53"  class=" tableEdit Product_motif_table dataTable"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="V46ab22a3cfb53"  class=" tableEdit Product_motif_table dataTable"
 |- {{table heading style}}
 !|Type!!Residues!!Description!!Notes!!References
@@ Line 736: / Line 827: @@
 ||
 View models at:
-* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
+* [http://www.proteinmodelportal.org/query/uniprot/P23367 Protein Model Portal]
-* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
+* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P23367 PSI-PRED (P23367)]
-* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
+* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P23367 Genomes TO Protein (P23367)] (GTOP)
-* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
-* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)
 |- class="tableEdit_footer"
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 *
 ****************************************************************************************** -->{{Product_resources_help}}
-{|   id="E46ab22a5d6668"  class=" tableEdit Product_resource_table"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="E46ab22a5d6668"  class=" tableEdit Product_resource_table"
 |- {{table_heading_style}}
 !|Resource type!!Source!!Notes/Reference
@@ Line 878: / Line 967: @@
 Purified protein
 |
-MutL G238D<ref name='PMID:12606120'/>
+MutL K159E<ref name='PMID:12606120'/>
 |
-*Confers a dominant mutator phenotype
+*Alters the residues around the DNA binding cleft
-*Insolubility issues prevented ''in vitro'' assays
+*~10-fold reduction in ATP hydrolysis
+*Defective in DNA binding
+*Fails to activate MMR and block homologous recombination
 |-
 |
 Purified protein
 |
-MutL K159E<ref name='PMID:12606120'/>
+MutL G238D<ref name='PMID:12606120'/>
 |
-*Alters the residues around the DNA binding cleft
+*Confers a dominant mutator phenotype
-*~10-fold reduction in ATP hydrolysis
+*Insolubility issues prevented ''in vitro'' assays
-*Defective in DNA binding
-*Fails to activate MMR and block homologous recombination
 |-
 |
@@ Line 902: / Line 991: @@
 *Mediates the mismatch-dependent activation of MutH ''in vitro''
 *Exhibits a mutator phenotype and increased homologous recombination ''in vivo''
+|-
+|
+Purification protocol
+|
+Single-step purification of His6-MutL
+|
+PMID:8747662
 |- class="tableEdit_footer"
@@ Line 921: / Line 1,017: @@
 *
 ****************************************************************************************** -->{{Gene_accessions_help}}
-{|   id="B46ab22a647845"  class=" tableEdit Gene_accessions_table"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="B46ab22a647845"  class=" tableEdit Gene_accessions_table"
 |- {{table_heading_style}}
 !|Database!!Accession!!Notes
 |-
 |
-[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
+|
+[http://www.ncbi.nlm.nih.gov/protein/16131992 GI:16131992]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
+|
+[http://www.ncbi.nlm.nih.gov/protein/NP_418591.1 GeneID:948691]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[[ASAP]]
 |
-[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG11281-MONOMER EcoCyc:EG11281-MONOMER]
+ASAP:ABE-0013655
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
+|-
+|
+[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+|
+[http://www.uniprot.org/uniprot/P23367 UniProtKB/Swiss-Prot:P23367]
+|
+Escherichia coli str. K-12 substr. MG1655
+|-
+|
+[[EcoCyc]]
+|
+EcoCyc:EG11281
+|
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
+|-
+|
+[[EcoGene]]
+|
+EcoGene:EG11281
+|
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
+[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
 |
-[[uniprot:P23367|UniProt:P23367]]
+[http://www.ncbi.nlm.nih.gov/gene?term=948691 GeneID:948691]
 |
+Escherichia coli str. K-12 substr. MG1655
 |-
 |
-[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
+[[RegulonDB]]
 |
-[http://pfam.janelia.org/protein/P23367 Pfam:P23367]
+RegulonDB:ECK120001254
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
 |-
 |
-[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
+[[EchoBASE]]
 |
-[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418591 RefSeq:NP_418591]
+EchoBASE:EB1258
 |
+''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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-{|   id="L46ab22aac813e"  class=" tableEdit Links_table"
+{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="L46ab22aac813e"  class=" tableEdit Links_table"
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 [[Category:Proteins]]
+[[Category:RefGenome_Annotated_Gene]]

mutL:Gene Product(s): Difference between revisions

Latest revision as of 21:13, 17 February 2015

Nomenclature

Notes

Function

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Localization

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Structure and Physical Properties

Structure figures

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Gene Product Resources

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Accessions in Other Databases

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