PMID:19376855
| Citation |
Polosina, YY, Mui, J, Pitsikas, P and Cupples, CG (2009) The Escherichia coli mismatch repair protein MutL recruits the Vsr and MutH endonucleases in response to DNA damage. J. Bacteriol. 191:4041-3 |
|---|---|
| Abstract |
The activities of the Vsr and MutH endonucleases of Escherichia coli are stimulated by MutL. The interaction of MutL with each enzyme is enhanced in vivo by 2-aminopurine treatment and by inactivation of the mutY gene. We hypothesize that MutL recruits the endonucleases to sites of DNA damage. |
| Links |
PubMed PMC2698396 Online version:10.1128/JB.00066-09 |
| Keywords |
Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; DNA Damage; DNA Mismatch Repair; DNA Repair Enzymes/genetics; DNA Repair Enzymes/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Endodeoxyribonucleases/genetics; Endodeoxyribonucleases/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Protein Binding |
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