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On One Page

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Gene |

Product(s) |

Expression|

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Standard Name	zapC
Gene Synonym(s)	ECK0937, b0946, JW5125^[1], ycbW, JW5125
Product Desc.	Stabilizer of the FtsZ ring.^[2] ^[3]
Product Synonyms(s)	predicted protein^[1], B0946^[4]^[1], YcbW^[4]^[1] , ZapC, ECK0937, JW5125, b0946
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ycbW^[4]
Regulation/Activity
Quick Links
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Notes

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aka ZapC

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	zapC
Mnemonic	Systematic nomenclature
Synonyms	ECK0937, b0946, JW5125^[1], ycbW, JW5125
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	21.66 minutes	MG1655: 1005175..1005717 <gbrowseImage> name=NC_000913:1005175..1005717 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1023043..1023585 <gbrowseImage> name=NC_012967:1023043..1023585 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 908143..908685 <gbrowseImage> name=NC_012759:908143..908685 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1006374..1006916 <gbrowseImage> name=NC_007779:1006374..1006916 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1059103..1059645 <gbrowseImage> name=NC_010473:1059103..1059645 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability
ΔycbW (Keio:JW5125)	deletion	deletion			PMID:16738554	Shigen
ParaBAD-zapC + arabinose			Cell Shape	Cells slightly elongated when grown in rich medium.	PMID:21216995
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW5125	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCGAATTAAACCAGACGATAA Primer 2:CCGACTGCCTGTTCGAGGCTGAA
zcb-3059::Tn10	Linked marker	CAG12094 = CGSC7358^[5]	est. P1 cotransduction: 91% ^[6]
zcc-282::Tn10	Linked marker	CAG18466 = CGSC7359^[5]	est. P1 cotransduction: 6% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6486	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13715	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003086	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945552	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3479	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003204	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	ZapC
Synonyms	predicted protein^[1], B0946^[4]^[1], YcbW^[4]^[1] , ZapC, ECK0937, JW5125, b0946
Product description	Stabilizer of the FtsZ ring.^[2] ^[3]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0051302	regulation of cell division	PMID:21216995	IMP: Inferred from Mutant Phenotype		P		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type

Partner

Notes

References

Evidence

Protein

FtsZ

PMID:21216995

PMID:21216997

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLLRFYRVGE RQMRIKPDDN WRWYYDEEHD RMMLDLANGM LFRSRFARKM LTPDAFSPAG FCVDDAALYF SFEEKCRDFN LSKEQKAELV LNALVAIRYL KPQMPKSWHF VSHGEMWVPM PGDAACVWLS DTHEQVNLLV VESGENAALC LLAQPCVVIA GRAMQLGDAI KIMNDRLKPQ VNVDSFSLEQ AV
Length	192
Mol. Wt	22.138 kDa
pI	5.8 (calculated)
Extinction coefficient	34,950 - 35,575 (calc based on 5 Y, 5 W, and 5 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	21..175	PF07126 Protein of unknown function (DUF1379)		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ycbW taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111193	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945552	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003204	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P75862	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6486	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13715	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945552	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003086	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3479	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	155	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	280	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	243	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ycbW
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1005155..1005195 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0946 (EcoliWiki Page)	NCBI GEO profiles for ycbW
microarray	GenExpDB:b0946 (EcoliWiki Page)	Summary of data for ycbW from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1004907..1005158) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ13; Well:C11^[7]
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Notes

Accessions Related to ycbW Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6486	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3479	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0946
EcoGene	EcoGene:EG13715	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003086	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003204	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	YCBW	From SHIGELLACYC
E. coli O157	YCBW	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF07126 Protein of unknown function (DUF1379)
EcoCyc	EcoCyc:G6486	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13715	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003086	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3479	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0003204	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 Durand-Heredia, JM et al. (2011) Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J. Bacteriol. 193 1405-13 PubMed
↑ ^3.0 ^3.1 Hale, CA et al. (2011) Identification of Escherichia coli ZapC (YcbW) as a component of the division apparatus that binds and bundles FtsZ polymers. J. Bacteriol. 193 1393-404 PubMed
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

zapC:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to ycbW Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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