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On One Page

Quickview |

Gene |

Product(s) |

Expression|

Evolution |

References |

Quickview

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Standard Name	yjeP
Gene Synonym(s)	ECK4155, b4159, JW4120^[1], JW4120
Product Desc.	YjeP : Small Mechanosensitive Ion Channel (MscS) Homolog^[2]; predicted mechanosensitive channel^[3] Putative mechanosensitive channel protein, function unknown; deletion mutant has no obvious phenotype^[4]
Product Synonyms(s)	predicted mechanosensitive channel^[1], B4159^[2]^[1], YjeP^[2]^[1] , ECK4155, JW4120, b4159
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yjeP^[2]
Regulation/Activity
Quick Links
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Notes

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mscS, kefA, yjeP, ybiO, ybdG and ynaI are paralogs.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	yjeP
Mnemonic	Systematic nomenclature
Synonyms	ECK4155, b4159, JW4120^[1], JW4120
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	94.49 minutes	MG1655: 4387393..4384070 <gbrowseImage> name=NC_000913:4384070..4387393 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 4367525..4364202 <gbrowseImage> name=NC_012967:4364202..4367525 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 4322805..4326128 <gbrowseImage> name=NC_012759:4322805..4326128 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 4394050..4390727 <gbrowseImage> name=NC_007779:4390727..4394050 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4487755..4484432 <gbrowseImage> name=NC_010473:4484432..4487755 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔyjeP (Keio:JW4120)	deletion	deletion	PMID:16738554	Shigen CGSC10967^[5]
ΔyjeP786::kan			PMID:16738554	CGSC:105518
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW4120	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCGCCTGATTATCACTTTTCT Primer 2:CCtAAACTTCCCGCCTGACGACC
1D4	Kohara Phage	Genobase	PMID:3038334
3H6	Kohara Phage	Genobase	PMID:3038334
cadB2231::Tn10	Linked marker	CAG18488 = CGSC7479^[5]	est. P1 cotransduction: 35% ^[6] Synonyms:zjd-2231::Tn10
cycA30::Tn10	Linked marker	CAG12073 = CGSC7482^[5]	est. P1 cotransduction: 16% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (EcoliWiki Page)	GeneID:948676	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YjeP
Synonyms	predicted mechanosensitive channel^[1], B4159^[2]^[1], YjeP^[2]^[1] , ECK4155, JW4120, b4159
Product description	YjeP : Small Mechanosensitive Ion Channel (MscS) Homolog^[2]; predicted mechanosensitive channel^[3] Putative mechanosensitive channel protein, function unknown; deletion mutant has no obvious phenotype^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006685	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006686	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011014	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011066	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016021	integral to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9909	C	Seeded from EcoCyc (v14.0)	complete
	GO:0055085	transmembrane transport	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006685	P	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	lon	PMID:16606699	Experiment(s):EBI-1147585
Protein	dnaE	PMID:16606699	Experiment(s):EBI-1147585
Protein	clpA	PMID:16606699	Experiment(s):EBI-1147585
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MRLIITFLMA WCLSWGAYAA TAPDSKQITQ ELEQAKAAKP AQPEVVEALQ SALNALEERK GSLERIKQYQ QVIDNYPKLS ATLRAQLNNM RDEPRSVSPG MSTDALNQEI LQVSSQLLDK SRQAQQEQER AREIADSLNQ LPQQQTDARR QLNEIERRLG TLTGNTPLNQ AQNFALQSDS ARLKALVDEL ELAQLSANNR QELARLRSEL AEKESQQLDA YLQALRNQLN SQRQLEAERA LESTELLAEN SADLPKDIVA QFKINRELSA ALNQQAQRMD LVASQQRQAA SQTLQVRQAL NTLREQSQWL GSSNLLGEAL RAQVARLPEM PKPQQLDTEM AQLRVQRLRY EDLLNKQPLL RQIHQADGQP LTAEQNRILE AQLRTQRELL NSLLQGGDTL LLELTKLKVS NGQLEDALKE VNEATHRYLF WTSDVRPMTI AWPLEIAQDL RRLISLDTFS QLGKASVMML TSKETILPLF GALILVGCSI YSRRYFTRFL ERSAAKVGKV TQDHFWLTLR TLFWSILVAS PLPVLWMTLG YGLREAWPYP LAVAIGDGVT ATVPLLWVVM ICATFARPNG LFIAHFGWPR ERVSRGMRYY LMSIGLIVPL IMALMMFDNL DDREFSGSLG RLCFILICGA LAVVTLSLKK AGIPLYLNKE GSGDNITNHM LWNMMIGAPL VAILASAVGY LATAQALLAR LETSVAIWFL LLVVYHVIRR WMLIQRRRLA FDRAKHRRAE MLAQRARGEE EAHHHSSPEG AIEVDESEVD LDAISAQSLR LVRSILMLIA LLSVIVLWSE IHSAFGFLEN ISLWDVTSTV QGVESLEPIT LGAVLIAILV FIITTQLVRN LPALLELAIL QHLDLTPGTG YAITTITKYL LMLIGGLVGF SMIGIEWSKL QWLVAALGVG LGFGLQEIFA NFISGLIILF EKPIRIGDTV TIRDLTGSVT KINTRATTIS DWDRKEIIVP NKAFITEQFI NWSLSDSVTR VVLTIPAPAD ANSEEVTEIL LTAARRCSLV IDNPAPEVFL VDLQQGIQIF ELRIYAAEMG HRMPLRHEIH QLILAGFHAH GIDMPFPPFQ MRLESLNGKQ TGRTLTSAGK GRQAGSL
Length	1,107
Mol. Wt	123.972 kDa
pI	10.5 (calculated)
Extinction coefficient	136,820 - 137,570 (calc based on 18 Y, 20 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
motif	1-19	UniProt Manual:Signal Peptides	UniProt:P39285
Domain	874..1075	PF00924 Mechanosensitive ion channel		PMID:19920124
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yjeP taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16131984	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948676	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P39285	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948676	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	146	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	51	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	72	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yjeP
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:4387373..4387413 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b4159 (EcoliWiki Page)	NCBI GEO profiles for yjeP
microarray	GenExpDB:b4159 (EcoliWiki Page)	Summary of data for yjeP from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to yjeP Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b4159
RegulonDB	RegulonDB:	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000001378 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00039942 (score: 1.000; bootstrap: 100%) WBGene00039941 (score: 0.443)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00003052 (score: 1.000; bootstrap: 100%) WBGene00002053 (score: 0.117) WBGene00003485 (score: 0.115) WBGene00002052 (score: 0.108) WBGene00002050 (score: 0.106) WBGene00002051 (score: 0.103) WBGene00002054 (score: 0.078) WBGene00002057 (score: 0.054)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000008062 (score: 1.000; bootstrap: 100%) ENSCAFP00000027841 (score: 0.555) ENSCAFP00000025317 (score: 0.467) ENSCAFP00000025885 (score: 0.089)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000012164 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000010710 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000305699 (score: 1.000; bootstrap: 100%) ENSP00000257142 (score: 0.553) ENSP00000264827 (score: 0.471) ENSP00000282163 (score: 0.068)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000026290 (score: 1.000; bootstrap: 100%) ENSMMUP00000002862 (score: 0.050)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000021489 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Mus musculus	MGI:2387183 (score: 1.000; bootstrap: 50%)	From Inparanoid:20070104
Oryza gramene	Q5KQK3 (score: 1.000; bootstrap: 100%) Q5VR43 (score: 0.473)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000034620 (score: 1.000; bootstrap: 100%) ENSPTRP00000001371 (score: 0.538) ENSPTRP00000017996 (score: 0.241) ENSPTRP00000011302 (score: 0.068)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000023153 (score: 1.000; bootstrap: 100%) ENSRNOP00000029680 (score: 0.082) ENSRNOP00000028432 (score: 0.065)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000157441 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000160962 (score: 0.431) NEWSINFRUP00000142957 (score: 0.194) NEWSINFRUP00000162893 (score: 0.174) NEWSINFRUP00000143156 (score: 0.064) NEWSINFRUP00000156946 (score: 0.060) NEWSINFRUP00000181188 (score: 0.052)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000022535 (score: 1.000; bootstrap: 100%) ENSXETP00000018642 (score: 1.000; bootstrap: 100%) ENSXETP00000010323 (score: 0.525) ENSXETP00000019497 (score: 0.484) ENSXETP00000020907 (score: 0.458) ENSXETP00000022374 (score: 0.391) ENSXETP00000041769 (score: 0.375) ENSXETP00000016267 (score: 0.371) ENSXETP00000022338 (score: 0.358) ENSXETP00000024447 (score: 0.325) ENSXETP00000035833 (score: 0.264) ENSXETP00000017563 (score: 0.258) ENSXETP00000015060 (score: 0.249) ENSXETP00000044178 (score: 0.226) ENSXETP00000044132 (score: 0.225) ENSXETP00000044083 (score: 0.222) ENSXETP00000044049 (score: 0.209) ENSXETP00000031600 (score: 0.189) ENSXETP00000044186 (score: 0.168) ENSXETP00000028679 (score: 0.163) ENSXETP00000027305 (score: 0.155) ENSXETP00000012359 (score: 0.155) ENSXETP00000025015 (score: 0.138) ENSXETP00000046177 (score: 0.136) ENSXETP00000046156 (score: 0.134) ENSXETP00000027293 (score: 0.121) ENSXETP00000003751 (score: 0.121) ENSXETP00000044359 (score: 0.112) ENSXETP00000034439 (score: 0.106) ENSXETP00000011292 (score: 0.105) ENSXETP00000052129 (score: 0.099) ENSXETP00000046870 (score: 0.089) ENSXETP00000040793 (score: 0.089) ENSXETP00000043085 (score: 0.075) ENSXETP00000009802 (score: 0.075) ENSXETP00000046162 (score: 0.074) ENSXETP00000034459 (score: 0.069) ENSXETP00000003915 (score: 0.059) ENSXETP00000044035 (score: 0.059) ENSXETP00000007664 (score: 0.051)	From Inparanoid:20070104
Shigella flexneri	YJEP	From SHIGELLACYC
E. coli O157	YJEP	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00924 Mechanosensitive ion channel
Superfamily (EcoliWiki Page)	SUPERFAMILY:50182
Superfamily (EcoliWiki Page)	SUPERFAMILY:82689
EcoCyc	EcoCyc:	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

yjeP:On One Page

Quickview

Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to yjeP Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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