tatA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

TatA

Synonyms

TatABCE protein translocation system subunit[1], TatA[2][1], YigT[2][1], B3836[2][1], twin-arginine translocase subunit, sec-independent protein export[2][1], MttA1[2][1] , ECK3830, JW3813, mttA1, yigT, b3836

Product description

TatA[2][3];

Component of TatABCE protein export complex[2][3]

Protein translocase, Sec-independent; mediates export of folded and ligand-bound proteins[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0009306

protein secretion

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00236

P

Seeded from EcoCyc (v14.0)

complete

GO:0009306

protein secretion

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006312

P

Seeded from EcoCyc (v14.0)

complete

GO:0009977

proton motive force dependent protein transmembrane transporter activity

PMID:11350936[5]

IMP: Inferred from Mutant Phenotype

F

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00236

P

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003369

P

Seeded from EcoCyc (v14.0)

complete

GO:0015031

protein transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006312

P

Seeded from EcoCyc (v14.0)

complete

GO:0008320

protein transmembrane transporter activity

PMID:9649434[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:tatE


F

replaced original annotation toGO:0008565, because this term was made obsolete

complete

GO:0015031

protein transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0653

P

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

PMID:12427031[7]

IDA: Inferred from Direct Assay

C

complete

GO:0016021

integral to membrane

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006312

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc (v14.0)

complete

GO:0016021

integral to membrane

PMID:16027357[8]

IPI: Inferred from Physical Interaction

C

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0033281

TAT protein transport complex

PMID:11279240[9]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of TatABCE protein export complex

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Inner membrane

PMID:14580344[10]

EchoLocation:tatA

Membrane anchored

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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc

MRLCLIIIYH RGTCMGGISI WQLLIIAVIV VLLFGTKKLG SIGSDLGASI KGFKKAMSDD
EPKQDKTSQD ADFTAKTIAD KQADTNQEQA KTEDAKRHDK EQV
Length

103

Mol. Wt

11.338 kDa

pI

8.0 (calculated)

Extinction coefficient

6,990 - 7,240 (calc based on 1 Y, 1 W, and 2 C residues)


Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

4..83

PF02416 mttA/Hcf106 family

PMID:19920124[11]

<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=tatA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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</protect>

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:90111653

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948321

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012541

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P69428

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:G7806

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11478

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948321

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120004314

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1444

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. Yahr, TL & Wickner, WT (2001) Functional reconstitution of bacterial Tat translocation in vitro. EMBO J. 20 2472-9 PubMed
  6. Sargent, F et al. (1998) Overlapping functions of components of a bacterial Sec-independent protein export pathway. EMBO J. 17 3640-50 PubMed
  7. Porcelli, I et al. (2002) Characterization and membrane assembly of the TatA component of the Escherichia coli twin-arginine protein transport system. Biochemistry 41 13690-7 PubMed
  8. Gohlke, U et al. (2005) The TatA component of the twin-arginine protein transport system forms channel complexes of variable diameter. Proc. Natl. Acad. Sci. U.S.A. 102 10482-6 PubMed
  9. Bolhuis, A et al. (2001) TatB and TatC form a functional and structural unit of the twin-arginine translocase from Escherichia coli. J. Biol. Chem. 276 20213-9 PubMed
  10. Alami, M et al. (2003) Differential interactions between a twin-arginine signal peptide and its translocase in Escherichia coli. Mol. Cell 12 937-46 PubMed
  11. Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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