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Expression|

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Standard Name	panC
Gene Synonym(s)	ECK0132, b0133, JW0129^[1], JW0129
Product Desc.	pantoate-β-alanine ligase^[2]^[3]; Component of pantoate-β-alanine ligase^[2]^[3] Pantothenate synthase, dimeric^[4]
Product Synonyms(s)	pantothenate synthetase^[1], B0133^[2]^[1], PanC^[2]^[1], pantoate activating enzyme^[2]^[1], (R)-pantoate:β-alanine ligase (AMP-forming)^[2]^[1] , ECK0132, JW0129, b0133
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): panBC^[2]
Regulation/Activity
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	panC
Mnemonic	Pantothenate
Synonyms	ECK0132, b0133, JW0129^[1], JW0129
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	3.19 minutes	MG1655: 148795..147944 <gbrowseImage> name=NC_000913:147944..148795 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 151598..150747 <gbrowseImage> name=NC_012967:150747..151598 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 147943..148794 <gbrowseImage> name=NC_012759:147943..148794 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 148795..147944 <gbrowseImage> name=NC_007779:147944..148795 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 122899..122048 <gbrowseImage> name=NC_010473:122048..122899 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
panC(del) (Keio:JW0129)	deletion	deletion	PMID:16738554	Shigen CGSC8405^[5]
panC4				CGSC:9097
panC5				CGSC:16831
panC750(del)::kan			PMID:16738554	CGSC:102248
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW0129	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTTAATTATCGAAACCCTGCC Primer 2:CCCGCCAGCTCGACCATTTTGTT
17C11	Kohara Phage	Genobase	PMID:3038334
11C5	Kohara Phage	Genobase	PMID:3038334
leuO3051::Tn10	Linked marker	CAG12095 = CGSC7324^[5]	est. P1 cotransduction: 3% ^[6] Synonyms:zab-3051::Tn10 nnnThe start of leuO was reannotated by Riley et al. (2006).
zad-220::Tn10	Linked marker	CAG12025 = CGSC7326^[5]	est. P1 cotransduction: 98% ^[6]
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11746	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11746	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001684	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:944958	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1696	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000465	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	PanC
Synonyms	pantothenate synthetase^[1], B0133^[2]^[1], PanC^[2]^[1], pantoate activating enzyme^[2]^[1], (R)-pantoate:β-alanine ligase (AMP-forming)^[2]^[1] , ECK0132, JW0129, b0133
Product description	pantoate-β-alanine ligase^[2]^[3]; Component of pantoate-β-alanine ligase^[2]^[3] Pantothenate synthase, dimeric^[4]
EC number (for enzymes)	6.3.2.1^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004592	pantoate-beta-alanine ligase activity	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_00158	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004592	pantoate-beta-alanine ligase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003721	F	Seeded from EcoCyc (v14.0)	complete
	GO:0004592	pantoate-beta-alanine ligase activity	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:6.3.2.1	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005829	cytosol	PMID:16858726	IDA: Inferred from Direct Assay		C	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of pantoate-β-alanine ligase	could be indirect
Protein	dnaK		PMID:15690043	Experiment(s):EBI-880983
Protein	panB		PMID:15690043	Experiment(s):EBI-880983
Protein	ushA		PMID:15690043	Experiment(s):EBI-880983, EBI-887604
Protein	purC		PMID:15690043	Experiment(s):EBI-887604
Protein	lacZ		PMID:16606699	Experiment(s):EBI-1135683
Protein	slyD		PMID:16606699	Experiment(s):EBI-1135683
Protein	carB		PMID:16606699	Experiment(s):EBI-1135683
Protein	purC		PMID:19402753	LCMS(ID Probability):99.6
Protein	ushA		PMID:19402753	LCMS(ID Probability):99.6 MALDI(Z-score):27.282210
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLIIETLPLL RQQIRRLRME GKRVALVPTM GNLHDGHMKL VDEAKARADV VVVSIFVNPM QFDRPEDLAR YPRTLQEDCE KLNKRKVDLV FAPSVKEIYP NGTETHTYVD VPGLSTMLEG ASRPGHFRGV STIVSKLFNL VQPDIACFGE KDFQQLALIR KMVADMGFDI EIVGVPIMRA KDGLALSSRN GYLTAEQRKI APGLYKVLSS IADKLQAGER DLDEIITIAG QELNEKGFRA DDIQIRDADT LLEVSETSKR AVILVAAWLG DARLIDNKMV ELA
Length	283
Mol. Wt	31.598 kDa
pI	6.2 (calculated)
Extinction coefficient	12,950 - 13,200 (calc based on 5 Y, 1 W, and 2 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	1..280	PF02569 Pantoate-beta-alanine ligase		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=panC taxon=562,83333 </beststructure>

Models

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16128126	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:944958	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000465	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P31663	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11746	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11746	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:944958	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001684	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1696	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MC4100	8.35E+02	molecules/cell	Medium: median data from rich and minimal media Temperature (°C): 37 Doubling time (min): Growth Rate(min): Growth phase: other:	emPAI		PMID:18304323
Protein	Ecoli K-12	53.307+/-0.41	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.12573443	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	3635	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	1425	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	2192	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
panBC
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:148775..148815 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b0133 (EcoliWiki Page)	NCBI GEO profiles for panC
microarray	GenExpDB:b0133 (EcoliWiki Page)	Summary of data for panC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to panC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11746	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1696	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b0133
EcoGene	EcoGene:EG11746	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001684	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000465	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Apis mellifera	ENSAPMP00000034740 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT5G48840 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0231511 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	O24210 (score: 1.000; bootstrap: 100%) Q851Y0 (score: 0.883)	From Inparanoid:20070104
Saccharomyces cerevisiae	YIL145C (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAC5H108c (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000040944 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	PANC	From SHIGELLACYC
E. coli O157	PANC	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:52374
Panther (EcoliWiki Page)	PTHR21299:SF1
Pfam (EcoliWiki Page)	PF02569 Pantoate-beta-alanine ligase
EcoCyc	EcoCyc:EG11746	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11746	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001684	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1696	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0000465	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

panC:On One Page

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Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to panC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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