panB:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PanB

Synonyms

3-methyl-2-oxobutanoate hydroxymethyltransferase[1], B0134[2][1], PanB[2][1], α-ketoisovalerate hydroxymethyltransferase[2][1], dehydropantoate hydroxymethyltransferase[2][1], ketopantoate hydroxymethyltransferase[2][1], 5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase[2][1] , ECK0133, JW0130, panA, b0134

Product description

3-methyl-2-oxobutanoate hydroxymethyltransferase[2][3];

Component of 3-methyl-2-oxobutanoate hydroxymethyltransferase[2][3]

Ketopantoate hydroxymethyltransferase[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0003864

3-methyl-2-oxobutanoate hydroxymethyltransferase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00156

F

Seeded from EcoCyc (v14.0)

complete

GO:0003864

3-methyl-2-oxobutanoate hydroxymethyltransferase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003700

F

Seeded from EcoCyc (v14.0)

complete

GO:0003864

3-methyl-2-oxobutanoate hydroxymethyltransferase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.1.2.11

F

Seeded from EcoCyc (v14.0)

complete

GO:0005829

cytosol

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0016020

membrane

PMID:16858726[5]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of 3-methyl-2-oxobutanoate hydroxymethyltransferase

could be indirect

Protein

ileS

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

pflA

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

rpsD

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

iscS

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

carA

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

slyD

PMID:16606699[6]

Experiment(s):EBI-1135688

Protein

tig

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpmC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsT

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

rpsJ

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

cspC

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

pgm

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

ppsA

PMID:19402753[7]

LCMS(ID Probability):99.6

Protein

talB

PMID:19402753[7]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKPTTISLLQ KYKQEKKRFA TITAYDYSFA KLFADEGLNV MLVGDSLGMT VQGHDSTLPV
TVADIAYHTA AVRRGAPNCL LLADLPFMAY ATPEQAFENA ATVMRAGANM VKIEGGEWLV
ETVQMLTERA VPVCGHLGLT PQSVNIFGGY KVQGRGDEAG DQLLSDALAL EAAGAQLLVL
ECVPVELAKR ITEALAIPVI GIGAGNVTDG QILVMHDAFG ITGGHIPKFA KNFLAETGDI
RAAVRQYMAE VESGVYPGEE HSFH
Length

264

Mol. Wt

28.236 kDa

pI

5.1 (calculated)

Extinction coefficient

17,420 - 17,795 (calc based on 8 Y, 1 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

2..260

PF02548 Ketopantoate hydroxymethyltransferase

PMID:19920124[8]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=panB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128127

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944839

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000467

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P31057

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11675

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11675

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944839

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001618

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1626

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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