marA:Gene
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Location(s) and DNA Sequence | Sequence Features | Alleles and Phenotypes | Genetic Interactions | Genetic Resources | Accessions | Links | References | Suggestions |
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Nomenclature
See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.
| Standard name |
marA |
|---|---|
| Mnemonic |
Multiple antibiotic resistance |
| Synonyms |
ECK1524, b1531, JW5249, cfxB, norB, soxQ, inaR, nfxC[1], nfxC |
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Notes
Location(s) and DNA Sequence
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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.
| Strain | Map location | Genome coordinates | Genome browsers | Sequence links |
|---|---|---|---|---|
|
MG1655 |
34.86 minutes |
MG1655: 1617598..1617981 |
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NC_012967: 1587340..1587723 |
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NC_012759: 1509657..1510040 |
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W3110 |
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W3110: 1621288..1621671 |
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DH10B: 1707223..1707606 |
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Notes
Sequence Features
See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.
| Feature Type | Strain | Genomic Location | Evidence | Reference | Notes |
|---|---|---|---|---|---|
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Notes
Alleles and Phenotypes
See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.
| Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments |
|---|---|---|---|---|---|---|---|
|
marA(del) (Keio:JW5249) |
deletion |
deletion |
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marA::Tn5KAN-2 (FB20350) |
Insertion at nt 248 in Plus orientation |
contains pKD46 | |||||
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marA::Tn5KAN-2 (FB20351) |
Insertion at nt 248 in Plus orientation |
does not contain pKD46 | |||||
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marA752(del)::kan |
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marA1 |
Resistant to |
provides multiple antibiotic resistance |
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soxQ1 |
Resistant to |
expresses multiple antibiotic resistance (elevated resistance to redox agents- menadione- and antibiotics- chloramphenicol and nalidixic acid) and diminished rate of synthesis of OmpF |
also showed increased resistance to ampicillin and tetracycline Constitutively over-expressed the micF RNA | ||||
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cfxB1 |
Resistant to |
provided increased resistance to ampicillin and tetracycline and constitutively over-expressed the micF RNA |
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|
marA1 |
Resistant to |
Resistant to Menadione |
strain: JHC1113 |
Table 2. The table also have allelic variations with the same phenotype. | |||
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Notes
Genetic Interactions
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| Interactor | Interaction | Allele | Score(s) | Reference(s) | Accessions | Notes |
|---|---|---|---|---|---|---|
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Notes
Genetic Resources
See Help:Gene_resources for help entering information into the Genetic Resources table.
| Resource | Resource Type | Source | Notes/Reference |
|---|---|---|---|
|
JW5249 |
Plasmid clone |
Status:Clone OK Primer 1:GCCTCCAGACGCAATACTGACGC Primer 2:CCGCTGTTGTAATGATTTAATGG | |
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Kohara Phage |
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Kohara Phage |
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|
Linked marker |
est. P1 cotransduction: % [9] | ||
|
zdi-925::Tn10 |
Linked marker |
est. P1 cotransduction: % [9] | |
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Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Escherichia coli str. K-12 substr. MG1655 | ||
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Notes
Links
| Name | URL | Comments |
|---|---|---|
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References
See Help:References for how to manage references in EcoliWiki.
- ↑ Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed
- ↑ 3.0 3.1 3.2 CGSC: The Coli Genetics Stock Center
- ↑ 4.0 4.1 Kang, Y et al. (2004) Systematic mutagenesis of the Escherichia coli genome. J. Bacteriol. 186 4921-30 PubMed
- ↑ 5.0 5.1 5.2 Chou, JH et al. (1993) Posttranscriptional repression of Escherichia coli OmpF protein in response to redox stress: positive control of the micF antisense RNA by the soxRS locus. J. Bacteriol. 175 1026-31 PubMed
- ↑ 6.0 6.1 6.2 Greenberg, JT et al. (1991) Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coli. J. Bacteriol. 173 4433-9 PubMed
- ↑ Kitagawa, M et al. (2005) Complete set of ORF clones of Escherichia coli ASKA library (a complete set of E. coli K-12 ORF archive): unique resources for biological research. DNA Res. 12 291-9 PubMed
- ↑ 8.0 8.1 Kohara, Y et al. (1987) The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library. Cell 50 495-508 PubMed
- ↑ 9.0 9.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
