malE:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MalE

Synonyms

maltose transporter subunit[1], periplasmic-binding component of ABC superfamily[1], B4034[2][1], MalE[2][1], MBP[2][1] , ECK4026, JW3994, malJ, b4034

Product description

MalE[2][3];

Component of maltose ABC transporter[2][3]; Maltose/Maltodextrin Transport System[3]

Maltose-binding protein, periplasmic; MBP; substrate recognition for active transport of and chemotaxis toward maltose and maltodextrin[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0048030

disaccharide binding

PMID:8399200[5]

IPI: Inferred from Physical Interaction

F

b-cyclodextrin

Missing: with/from

GO:0005363

maltose transmembrane transporter activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006060

F

Seeded from EcoCyc (v14.0)

complete

GO:0015768

maltose transport

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006060

P

Seeded from EcoCyc (v14.0)

complete

GO:0015768

maltose transport

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

P

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0042597

periplasmic space

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0574

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0200

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

PMID:15117946[7]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0042597

periplasmic space

PMID:2002054[8]

IDA: Inferred from Direct Assay

C

Seeded from EcoCyc (v14.0)

complete

GO:0048030

disaccharide binding

PMID:8399200[5]

IPI: Inferred from Physical Interaction

F

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

C

Seeded from EcoCyc (v14.0)

Missing: with/from

GO:0006974

response to DNA damage stimulus

PMID:11967071[9]

IEP: Inferred from Expression Pattern

P

complete

GO:0015768

maltose transport

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki:malK|EcoliWiki:malF|EcoliWiki:malG

P

complete

GO:0042597

periplasmic space

PMID:2002054[8] PMID:15117946[7]

IDA: Inferred from Direct Assay

C

complete

GO:0006810

transport

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki:malK|EcoliWiki:malF|EcoliWiki:malG

P

complete

GO:0008643

carbohydrate transport

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki:malK|EcoliWiki:malF|EcoliWiki:malG

P

complete

GO:0015423

ATPase-coupled maltose transmembrane transporter activity

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki


F

Replaced original annotation toGO:0005215 which has been made obsolete.

complete

GO:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki:malK|EcoliWiki:malF|EcoliWiki:malG

C

complete

GO:0043190

ATP-binding cassette (ABC) transporter complex

PMID:2155217[6]

IGI: Inferred from Genetic Interaction

EcoliWiki:lamB|EcoliWiki:malK|EcoliWiki:malF|EcoliWiki:malG

C

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of maltose ABC transporter

could be indirect

Protein

Subunits of Maltose/Maltodextrin Transport System

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Periplasm

PMID:9298646[10]

EchoLocation:malE

periplasm

From EcoCyc[3]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MKIKTGARIL ALSALTTMMF SASALAKIEE GKLVIWINGD KGYNGLAEVG KKFEKDTGIK
VTVEHPDKLE EKFPQVAATG DGPDIIFWAH DRFGGYAQSG LLAEITPDKA FQDKLYPFTW
DAVRYNGKLI AYPIAVEALS LIYNKDLLPN PPKTWEEIPA LDKELKAKGK SALMFNLQEP
YFTWPLIAAD GGYAFKYENG KYDIKDVGVD NAGAKAGLTF LVDLIKNKHM NADTDYSIAE
AAFNKGETAM TINGPWAWSN IDTSKVNYGV TVLPTFKGQP SKPFVGVLSA GINAASPNKE
LAKEFLENYL LTDEGLEAVN KDKPLGAVAL KSYEEELAKD PRIAATMENA QKGEIMPNIP
QMSAFWYAVR TAVINAASGR QTVDEALKDA QTRITK
Length

396

Mol. Wt

43.389 kDa

pI

5.5 (calculated)

Extinction coefficient

66,350 (calc based on 15 Y, 8 W, and 0 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-26

UniProt Manual:Signal Peptides

UniProt:P0AEX9

Domain

37..317

PF01547 Bacterial extracellular solute-binding protein

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=malE taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131860

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948538

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0013200

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0AEX9

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10554

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10554

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948538

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000547

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0549

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 2.4 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Sharff, AJ et al. (1993) Refined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein. Biochemistry 32 10553-9 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 Davidson, AL & Nikaido, H (1990) Overproduction, solubilization, and reconstitution of the maltose transport system from Escherichia coli. J. Biol. Chem. 265 4254-60 PubMed
  7. ↑ 7.0 7.1 Austermuhle, MI et al. (2004) Maltose-binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport. J. Biol. Chem. 279 28243-50 PubMed
  8. ↑ 8.0 8.1 Spurlino, JC et al. (1991) The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis. J. Biol. Chem. 266 5202-19 PubMed
  9. ↑ Khil, PP & Camerini-Otero, RD (2002) Over 1000 genes are involved in the DNA damage response of Escherichia coli. Mol. Microbiol. 44 89-105 PubMed
  10. ↑ Link, AJ et al. (1997) Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12. Electrophoresis 18 1259-313 PubMed
  11. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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