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Expression|

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Standard Name	hisP
Gene Synonym(s)	ECK2300, b2306, JW2303^[1], JW2303
Product Desc.	HisP^[2]^[3] Histidine permease^[4]
Product Synonyms(s)	histidine/lysine/arginine/ornithine transporter subunit^[1], ATP-binding component of ABC superfamily^[1], B2306^[2]^[1], HisP^[2]^[1] , ECK2300, JW2303, b2306
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): argT-hisJQMP^[2]
Regulation/Activity
Quick Links
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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	hisP
Mnemonic	Histidine
Synonyms	ECK2300, b2306, JW2303^[1], JW2303
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	52.2 minutes	MG1655: 2422531..2421758 <gbrowseImage> name=NC_000913:2421758..2422531 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 2368101..2367328 <gbrowseImage> name=NC_012967:2367328..2368101 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 2307563..2308336 <gbrowseImage> name=NC_012759:2307563..2308336 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 2429955..2429182 <gbrowseImage> name=NC_007779:2429182..2429955 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 2514296..2513523 <gbrowseImage> name=NC_010473:2513523..2514296 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔhisP (Keio:JW2303)	deletion	deletion	PMID:16738554	Shigen CGSC9851^[5]
ΔhisP778::kan			PMID:16738554	CGSC:101380
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW2303	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCTCCGAGAATAAATTAAACGT Primer 2:CCTTTCAGCGATCCCTTAAGGAA
E9C9	Kohara Phage	Genobase	PMID:3038334
9D2	Kohara Phage	Genobase	PMID:3038334
zfb-223::Tn10	Linked marker	CAG18484 = CGSC7406^[5]	est. P1 cotransduction: 28% ^[6] Synonyms:zej-223::Tn10
zfd-1::Tn10	Linked marker	CAG18467 = CGSC7408^[5]	est. P1 cotransduction: 2% ^[6] Synonyms:zfb-1::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10452	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10452	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000445	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946789	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0447	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007610	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	HisP
Synonyms	histidine/lysine/arginine/ornithine transporter subunit^[1], ATP-binding component of ABC superfamily^[1], B2306^[2]^[1], HisP^[2]^[1] , ECK2300, JW2303, b2306
Product description	HisP^[2]^[3] Histidine permease^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0015817	histidine transport	PMID:4920090	ISA: Inferred from Sequence Alignment	UniProtKB:P02915	P	95% identity, 98% similarity over entire protein	complete
	GO:0000166	nucleotide binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	Seeded from EcoCyc (v14.0)	complete
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005886	plasma membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-1003	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006810	transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006865	amino acid transport	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0029	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016020	membrane	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc (v14.0)	complete
	GO:0016887	ATPase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003439	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016887	ATPase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR017871	F	Seeded from EcoCyc (v14.0)	complete
	GO:0017111	nucleoside-triphosphatase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003593	F	Seeded from EcoCyc (v14.0)	complete
	GO:0019898	extrinsic to membrane	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-9903	C	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	groL		PMID:16606699	Experiment(s):EBI-1142524
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
cytoplasm			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSENKLNVID LHKRYGEHEV LKGVSLQANA GDVISIIGSS GSGKSTFLRC INFLEKPSEG SIVVNGQTIN LVRDKDGQLK VADKNQLRLL RTRLTMVFQH FNLWSHMTVL ENVMEAPIQV LGLSKQEARE RAVKYLAKVG IDERAQGKYP VHLSGGQQQR VSIARALAME PEVLLFDEPT SALDPELVGE VLRIMQQLAE EGKTMVVVTH EMGFARHVST HVIFLHQGKI EEEGAPEQLF GNPQSPRLQR FLKGSLK
Length	257
Mol. Wt	28.652 kDa
pI	8.1 (calculated)
Extinction coefficient	9,970 - 10,095 (calc based on 3 Y, 1 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	45..181	PF00005 ABC transporter		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=hisP taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16130241	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946789	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007610	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P07109	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG10452	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10452	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946789	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000445	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0447	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	241	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	348	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	133	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
argT-hisJQMP
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:2422511..2422551 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b2306 (EcoliWiki Page)	NCBI GEO profiles for hisP
microarray	GenExpDB:b2306 (EcoliWiki Page)	Summary of data for hisP from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to hisP Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG10452	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0447	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b2306
EcoGene	EcoGene:EG10452	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000445	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007610	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Drosophila melanogaster	FBgn0031362 (score: 1.000; bootstrap: 69%) FBgn0032167 (score: 0.229) FBgn0025683 (score: 0.225) FBgn0020762 (score: 0.211) FBgn0031516 (score: 0.208) FBgn0031220 (score: 0.184) FBgn0052091 (score: 0.175) FBgn0031449 (score: 0.159) FBgn0031515 (score: 0.153) FBgn0003996 (score: 0.077) FBgn0003515 (score: 0.074) FBgn0020445 (score: 0.059)	From Inparanoid:20070104
Drosophila pseudoobscura	GA14594-PA (score: 1.000; bootstrap: 57%) GA16356-PA (score: 0.236) GA15545-PA (score: 0.235) GA19180-PA (score: 0.225) GA18458-PA (score: 0.185) GA16671-PA (score: 0.176) GA16397-PA (score: 0.154) GA15454-PA (score: 0.057)	From Inparanoid:20070104
Oryza gramene	Q5Z8H2 (score: 1.000; bootstrap: 87%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000130824 (score: 1.000; bootstrap: 57%) NEWSINFRUP00000130826 (score: 0.180) NEWSINFRUP00000167567 (score: 0.137) NEWSINFRUP00000182359 (score: 0.125) NEWSINFRUP00000177047 (score: 0.125) NEWSINFRUP00000168237 (score: 0.097) NEWSINFRUP00000171182 (score: 0.092)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00014344001 (score: 1.000; bootstrap: 57%) GSTENP00014343001 (score: 0.105) GSTENP00020877001 (score: 0.101) GSTENP00038511001 (score: 0.091) GSTENP00014937001 (score: 0.051)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000040164 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	HISP	From SHIGELLACYC
E. coli O157	HISP	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00005 ABC transporter
Panther (EcoliWiki Page)	PTHR24220:SF33
Superfamily (EcoliWiki Page)	SUPERFAMILY:52540
EcoCyc	EcoCyc:EG10452	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG10452	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120000445	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB0447	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0007610	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

hisP:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to hisP Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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