ftsA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

FtsA

Synonyms

ATP-binding cell division protein involved in recruitment of FtsK to Z ring[1], B0094[2][1], DivA[2][1], FtsA[2][1] , divA, ECK0095, JW0092, b0094

Product description

essential cell division protein FtsA[2][3]

Cell division and septation protein, specific role unknown; recruited to FtsZ ring[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000917

barrier septum formation

P

Missing: evidence, reference

GO:0007049

cell cycle

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003494

P

Seeded from EcoCyc (v14.0)

complete

GO:0007049

cell cycle

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020823

P

Seeded from EcoCyc (v14.0)

complete

GO:0007049

cell cycle

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0131

P

Seeded from EcoCyc (v14.0)

complete

GO:0032155

cell division site part

PMID:8917533[5]

IDA: Inferred from Direct Assay

C

complete

GO:0051301

cell division

PMID:4583216[6]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0008360

regulation of cell shape

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0133

P

Seeded from EcoCyc (v14.0)

complete

GO:0051301

cell division

PMID:8917533[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000910

cytokinesis

PMID:8917533[5]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aceE

PMID:15690043[7]

Experiment(s):EBI-881093

Protein

dnaJ

PMID:15690043[7]

Experiment(s):EBI-881093

Protein

dnaK

PMID:15690043[7]

Experiment(s):EBI-881093

Protein

mreB

PMID:15690043[7]

Experiment(s):EBI-881093

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-881093, EBI-888109

Protein

accD

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

cutA

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

nusG

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rho

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rplK

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rplT

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rplU

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

slyD

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

tdcE

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

yfiF

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

yhhA

PMID:15690043[7]

Experiment(s):EBI-888109

Protein

murB

PMID:19402753[8]

MALDI(Z-score):39.730525

Protein

tufB

PMID:19402753[8]

MALDI(Z-score):21.725028

Protein

tdcE

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

cutA

PMID:19402753[8]

LCMS(ID Probability):99.0

Protein

yhhA

PMID:19402753[8]

LCMS(ID Probability):99.0

FtsZ

Protein

ftsA

PMID:11053380[9]

yeast two-hybrid assay

Protein

ftsK44

ftsA R286W supresses ftsK44

PMID:16194242[10]


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Inner membrane

localizes to septum, dependent on interaction with FtsZ


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG VNDLESVVKC
VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS EEEVTQEDVE NVVHTAKSVR
VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS GVRMQAKVHL ITCHNDMAKN IVKAVERCGL
KVDQLIFAGL ASSYSVLTED ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT
SDIAYAFGTP PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR
YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR VFHTQVRIGA
PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR VTASVGSWIK RLNSWLRKEF
Length

420

Mol. Wt

45.328 kDa

pI

6.2 (calculated)

Extinction coefficient

28,880 - 30,005 (calc based on 12 Y, 2 W, and 9 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

10..196

PF02491 Cell division protein FtsA

PMID:19920124[11]

Domain

206..382

PF02491 Cell division protein FtsA

PMID:19920124[11]

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Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=ftsA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128087

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:944778

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0000331

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABH0

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10339

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10339

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:944778

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000333

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0335

Escherichia coli str. K-12 substr. MG1655

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Notes

Structure resembles actin, plus an extra domain.

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 Ma, X et al. (1996) Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein. Proc. Natl. Acad. Sci. U.S.A. 93 12998-3003 PubMed
  6. ↑ Ricard, M & Hirota, Y (1973) Process of cellular division in Escherichia coli: physiological study on thermosensitive mutants defective in cell division. J. Bacteriol. 116 314-22 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  9. ↑ Yim, L et al. (2000) Role of the carboxy terminus of Escherichia coli FtsA in self-interaction and cell division. J. Bacteriol. 182 6366-73 PubMed
  10. ↑ Geissler, B & Margolin, W (2005) Evidence for functional overlap among multiple bacterial cell division proteins: compensating for the loss of FtsK. Mol. Microbiol. 58 596-612 PubMed
  11. ↑ 11.0 11.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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