cyoA:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

CyoA

Synonyms

cytochrome o ubiquinol oxidase subunit II[1], B0432[2][1], CyoA[2][1] , ECK0426, JW0422, b0432

Product description

cytochrome bo terminal oxidase subunit II[2][3];

Component of cytochrome bo terminal oxidase[2][3]

Cytochrome o oxidase subunit II, lipoprotein; also called cytochrome bo(3) ubiquinol oxidase subunit II[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0004129

cytochrome-c oxidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002429

F

Seeded from EcoCyc (v14.0)

complete

GO:0004129

cytochrome-c oxidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011759

F

Seeded from EcoCyc (v14.0)

complete

GO:0004129

cytochrome-c oxidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015964

F

Seeded from EcoCyc (v14.0)

complete

GO:0005488

binding

PMID:7961841[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0005507

copper ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002429

F

Seeded from EcoCyc (v14.0)

complete

GO:0005507

copper ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011759

F

Seeded from EcoCyc (v14.0)

complete

GO:0005507

copper ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015964

F

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0997

C

Seeded from EcoCyc (v14.0)

complete

GO:0005886

plasma membrane

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-1003

C

Seeded from EcoCyc (v14.0)

complete

GO:0006810

transport

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc (v14.0)

complete

GO:0009055

electron carrier activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011759

F

Seeded from EcoCyc (v14.0)

complete

GO:0009055

electron carrier activity

PMID:3301837[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0009060

aerobic respiration

PMID:2981797[7]

IMP: Inferred from Mutant Phenotype

P

Seeded from EcoCyc (v14.0)

complete

GO:0009486

cytochrome bo3 ubiquinol oxidase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012141

F

Seeded from EcoCyc (v14.0)

complete

GO:0015078

hydrogen ion transmembrane transporter activity

PMID:2544445[8]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0015453

oxidoreduction-driven active transmembrane transporter activity

PMID:7961841[5]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

GO:0020037

heme binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015964

F

Seeded from EcoCyc (v14.0)

complete

GO:0022900

electron transport chain

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010514

P

Seeded from EcoCyc (v14.0)

complete

GO:0022900

electron transport chain

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR011759

P

Seeded from EcoCyc (v14.0)

complete

GO:0022900

electron transport chain

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0249

P

Seeded from EcoCyc (v14.0)

complete

GO:0005887

integral to plasma membrane

PMID:2162836[9]

IDA: Inferred from Direct Assay

C

complete

GO:0022904

respiratory electron transport chain

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015964

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006333

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010514

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012141

P

Seeded from EcoCyc (v14.0)

complete

GO:0055114

oxidation reduction

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

P

Seeded from EcoCyc (v14.0)

complete

GO:0070469

respiratory chain

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0679

C

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of [[:Category:Complex:cytochrome bo terminal oxidase|cytochrome bo terminal oxidase]]

could be indirect

Protein

kdpB

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

dadA

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

hflK

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

lon

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

groL

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

nagC

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

pflB

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

htpG

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

mukB

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

dinG

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

hslU

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

yoaA

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

dnaJ

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

helD

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

glpD

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

dnaK

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

galS

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

prs

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

ftsZ

PMID:16606699[10]

Experiment(s):EBI-1136570

Protein

rpsP

PMID:19402753[11]

LCMS(ID Probability):99.6

Protein

acpP

PMID:19402753[11]

LCMS(ID Probability):99.6

Protein

nusG

PMID:19402753[11]

LCMS(ID Probability):99.6

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

plasma membrane

C-terminus localized to the periplasm with 3 predicted transmembrane domains

Daley et al. (2005) [12]


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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MRLRKYNKSL GWLSLFAGTV LLSGCNSALL DPKGQIGLEQ RSLILTAFGL MLIVVIPAIL
MAVGFAWKYR ASNKDAKYSP NWSHSNKVEA VVWTVPILII IFLAVLTWKT THALEPSKPL
AHDEKPITIE VVSMDWKWFF IYPEQGIATV NEIAFPANTP VYFKVTSNSV MNSFFIPRLG
SQIYAMAGMQ TRLHLIANEP GTYDGISASY SGPGFSGMKF KAIATPDRAA FDQWVAKAKQ
SPNTMSDMAA FEKLAAPSEY NQVEYFSNVK PDLFADVINK FMAHGKSMDM TQPEGEHSAH
EGMEGMDMSH AESAH
Length

315

Mol. Wt

34.911 kDa

pI

7.3 (calculated)

Extinction coefficient

58,900 - 59,025 (calc based on 10 Y, 8 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-24

UniProt Manual:Signal Peptides

UniProt:P0ABJ1

Domain

127..225

PF00116 Cytochrome C oxidase subunit II, periplasmic domain

PMID:19920124[13]

Domain

239..286

PF06481 COX Aromatic Rich Motif

PMID:19920124[13]

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<motif_map/>

tmhmm.php?gene=cyoA&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=cyoA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128417

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945080

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001495

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0ABJ1

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10178

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10178

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945080

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000173

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0175

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Welter, R et al. (1994) Identification of the ubiquinol-binding site in the cytochrome bo3-ubiquinol oxidase of Escherichia coli. J. Biol. Chem. 269 28834-8 PubMed
  6. ↑ Lorence, RM et al. (1987) Cytochrome b558 monitors the steady state redox state of the ubiquinone pool in the aerobic respiratory chain of Escherichia coli. J. Biol. Chem. 262 10532-6 PubMed
  7. ↑ Au, DC et al. (1985) Isolation and characterization of an Escherichia coli mutant lacking the cytochrome o terminal oxidase. J. Bacteriol. 161 123-7 PubMed
  8. ↑ Puustinen, A et al. (1989) Cytochrome o (bo) is a proton pump in Paracoccus denitrificans and Escherichia coli. FEBS Lett. 249 163-7 PubMed
  9. ↑ Nakamura, H et al. (1990) Expression of cyoA and cyoB demonstrates that the CO-binding heme component of the Escherichia coli cytochrome o complex is in subunit I. J. Biol. Chem. 265 11193-7 PubMed
  10. ↑ 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 10.14 10.15 10.16 10.17 10.18 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ 11.0 11.1 11.2 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
  13. ↑ 13.0 13.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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