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On One Page

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Gene |

Product(s) |

Expression|

Evolution |

References |

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Standard Name	curA
Gene Synonym(s)	ECK1443, b1449, JW5907^[1], yncB, JW5907
Product Desc.	predicted oxidoreductase, Zn-dependent and NAD(P)-binding^[2]^[3] Function unknown^[4]
Product Synonyms(s)	predicted oxidoreductase, Zn-dependent and NAD(P)-binding^[1], B1449^[2]^[1], YncB^[2]^[1] , CurA, ECK1443, JW5907, b1449
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yncB^[2]
Regulation/Activity
Quick Links
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Notes

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AFMB Structural Genomics target No. 72 (http://afmb.cnrs-mrs.fr/article171.html).^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	curA
Mnemonic	Systematic nomenclature
Synonyms	ECK1443, b1449, JW5907^[1], yncB, JW5907
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	32.7 minutes	MG1655: 1517051..1518088 <gbrowseImage> name=NC_000913:1517051..1518088 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1489137..1490174 <gbrowseImage> name=NC_012967:1489137..1490174 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1409086..1410147 <gbrowseImage> name=NC_012759:1409086..1410147 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1520741..1521778 <gbrowseImage> name=NC_007779:1520741..1521778 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1607646..1608683 <gbrowseImage> name=NC_010473:1607646..1608683 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔyncB (Keio:JW5907)	deletion	deletion			PMID:16738554	Shigen
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
	Plasmid clone	Shigen	PMID:16769691 Status: Primer 1: Primer 2:
trg-2::Tn10	Linked marker	CAG12026 = CGSC7376^[5]	est. P1 cotransduction: 42% ^[6]
zdd-235::Tn10	Linked marker	CAG18461 = CGSC7378^[5]	est. P1 cotransduction: 51% ^[6] Synonyms:zdc-235::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6760	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13772	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003349	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946012	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3534	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004834	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	CurA
Synonyms	predicted oxidoreductase, Zn-dependent and NAD(P)-binding^[1], B1449^[2]^[1], YncB^[2]^[1] , CurA, ECK1443, JW5907, b1449
Product description	predicted oxidoreductase, Zn-dependent and NAD(P)-binding^[2]^[3] Function unknown^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0003824	catalytic activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016040	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005488	binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016040	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008152	metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR016040	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002085	F	Seeded from EcoCyc (v14.0)	complete
	GO:0008270	zinc ion binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013149	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002085	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013149	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016491	oxidoreductase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	F	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002085	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013149	P	Seeded from EcoCyc (v14.0)	complete
	GO:0055114	oxidation reduction	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0560	P	Seeded from EcoCyc (v14.0)	complete
	GO:0003674	molecular function	n/a	ND: No biological Data available		F		Missing: reference
	GO:0005575	cellular component	n/a	ND: No biological Data available		C		Missing: reference
	GO:0008150	biological process	n/a	ND: No biological Data available		P		Missing: reference
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	fepG	PMID:19402753	LCMS(ID Probability):98.6
Protein	feoB	PMID:19402753	LCMS(ID Probability):99.6
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLQRGCDGCK QNQSREPATI DGFMPKAQES IMGQQKQRNR RWVLASRPHG APVPENFRLE EDDVATPGEG QVLLRTVYLS LDPYMRGRMS DEPSYSPPVD IGGVMVGGTV SRVVESNHPD YQSGDWVLGY SGWQDYDISS GDDLVKLGDH PQNPSWSLGV LGMPGFTAYM GLLDIGQPKE GETLVVAAAT GPVGATVGQI GKLKGCRVVG VAGGAEKCRH ATEVLGFDVC LDHHADDFAE QLAKACPKGI DIYYENVGGK VFDAVLPLLN TSARIPVCGL VSSYNATELP PGPDRLPLLM ATVLKKRIRL QGFIIAQDYG HRIHEFQREM GQWVKEDKIH YREEITDGLE NAPQTFIGLL KGKNFGKVVI RVAGDD
Length	376
Mol. Wt	41.031 kDa
pI	5.7 (calculated)
Extinction coefficient	45,380 - 46,255 (calc based on 12 Y, 5 W, and 7 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	169..310	PF00107 Zinc-binding dehydrogenase		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=yncB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:226524714	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946012	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004834	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P76113	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6760	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13772	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946012	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003349	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3534	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	Ecoli K-12	52.44+/-0.603	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
mRNA	Ecoli K-12	0.06460945	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		by RNA_Seq	PMID:20671182
Protein	E. coli K-12 MG1655	77	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	462	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	55	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yncB
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Figure courtesy of RegulonDB

</protect>

Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1517031..1517071 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1449 (EcoliWiki Page)	NCBI GEO profiles for yncB
microarray	GenExpDB:b1449 (EcoliWiki Page)	Summary of data for yncB from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1516779..1516975) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ17; Well:C9^[7]
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Notes

Accessions Related to yncB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6760	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3534	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1449
EcoGene	EcoGene:EG13772	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003349	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004834	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Anopheles gambiae	ENSANGP00000020750 (score: 1.000; bootstrap: 99%) ENSANGP00000012490 (score: 0.372)	From Inparanoid:20070104
Apis mellifera	ENSAPMP00000006907 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Arabidopsis thaliana	AT5G16990 (score: 1.000; bootstrap: 99%) AT5G16970 (score: 0.874) AT5G17000 (score: 0.872) AT3G03080 (score: 0.729) AT1G26320 (score: 0.712) AT5G37940 (score: 0.667) AT5G37980 (score: 0.665) AT5G16960 (score: 0.660) AT5G38000 (score: 0.643) AT3G59845 (score: 0.498) AT5G16980 (score: 0.432) AT1G65560 (score: 0.348)	From Inparanoid:20070104
Bos taurus	ENSBTAP00000014649 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Caenorhabditis briggsae	WBGene00025949 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Caenorhabditis elegans	WBGene00010911 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000004469 (score: 1.000; bootstrap: 66%)	From Inparanoid:20070104
Ciona intestinalis	ENSCINP00000004207 (score: 1.000; bootstrap: 56%)	From Inparanoid:20070104
Danio rerio	ZDB-GENE-041212-80 (score: 1.000; bootstrap: 100%) ZDB-CDNA-041212-89 (score: 1.000; bootstrap: 99%)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0231606 (score: 1.000; bootstrap: 100%) DDB0186921 (score: 0.350)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000031994 (score: 1.000; bootstrap: 49%)	From Inparanoid:20070104
Homo sapiens	ENSP00000311572 (score: 1.000; bootstrap: 53%) ENSP00000339034 (score: 0.605)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000016746 (score: 1.000; bootstrap: 99%) ENSMMUP00000015080 (score: 0.544) ENSMMUP00000025928 (score: 0.405)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000005764 (score: 1.000; bootstrap: 53%)	From Inparanoid:20070104
Mus musculus	MGI:1914353 (score: 1.000; bootstrap: 60%)	From Inparanoid:20070104
Oryza gramene	Q53LC7 (score: 1.000; bootstrap: 99%) Q7XUK3 (score: 0.422) Q8S0M7 (score: 0.344) Q69XJ5 (score: 0.128)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000011071 (score: 1.000; bootstrap: 56%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000020335 (score: 1.000; bootstrap: 98%)	From Inparanoid:20070104
Saccharomyces cerevisiae	YML131W (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Schizosaccharomyces pombe	SPAPB24D38c (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000128105 (score: 1.000; bootstrap: 56%)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00025902001 (score: 1.000; bootstrap: 62%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000032291 (score: 1.000; bootstrap: 86%)	From Inparanoid:20070104
Shigella flexneri	YNCB	From SHIGELLACYC
E. coli O157	YNCB	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF00107 Zinc-binding dehydrogenase
Superfamily (EcoliWiki Page)	SUPERFAMILY:50129
Superfamily (EcoliWiki Page)	SUPERFAMILY:51735
Panther (EcoliWiki Page)	PTHR11695:SF313
EcoCyc	EcoCyc:G6760	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13772	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003349	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3534	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004834	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

curA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to yncB Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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