clpX:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

ClpX

Synonyms

ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease[1], B0438[2][1], LopC[2][1] , ECK0432, JW0428, lopC, b0438

Product description

ClpX[2][3];

Component of ClpX ATP-dependent protease specificity component and chaperone[3]; ClpAXP[3]; ClpXP[3]

ATPase subunit of ClpXP protease; ClpXP degrades ssrA-tagged proteins; molecular chaperone[4]

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00175

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004487

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013093

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00175

P

Seeded from EcoCyc (v14.0)

complete

GO:0006457

protein folding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004487

P

Seeded from EcoCyc (v14.0)

complete

GO:0006950

response to stress

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010603

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc (v14.0)

complete

GO:0016887

ATPase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010603

F

Seeded from EcoCyc (v14.0)

complete

GO:0017111

nucleoside-triphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0019538

protein metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010603

P

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0046983

protein dimerization activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010603

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00175

F

Seeded from EcoCyc (v14.0)

complete

GO:0051082

unfolded protein binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR004487

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of ClpX ATP-dependent protease specificity component and chaperone

could be indirect

Protein

clpA

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

clpB

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

metK

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

mreB

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

pstB

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

tufA

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

hscB

PMID:15690043[5]

Experiment(s):EBI-884518

Protein

ahpC

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

dnaK

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

grpE

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

rfbB

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

rpmC

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

rpmG

PMID:15690043[5]

Experiment(s):EBI-891405

Protein

slyB

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

intD

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

hypB

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

rho

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

dnaK

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

inaA

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

yhbJ

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

yibL

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

ybhK

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

sdhA

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

nadE

PMID:16606699[6]

Experiment(s):EBI-1136646

Protein

ahpC

PMID:19402753[7]

LCMS(ID Probability):99.0 MALDI(Z-score):2.017396

Protein

clpB

PMID:19402753[7]

MALDI(Z-score):28.584015

Protein

recA

PMID:19402753[7]

MALDI(Z-score):22.110074

Protein

pstB

PMID:19402753[7]

MALDI(Z-score):22.106865

Protein

mreB

PMID:19402753[7]

MALDI(Z-score):33.221749

Protein

rfbB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

metK

PMID:19402753[7]

MALDI(Z-score):33.591550

Protein

Subunits of ClpAXP

could be indirect

Protein

Subunits of ClpXP

could be indirect


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MTDKRKDGSG KLLYCSFCGK SQHEVRKLIA GPSVYICDEC VDLCNDIIRE EIKEVAPHRE
RSALPTPHEI RNHLDDYVIG QEQAKKVLAV AVYNHYKRLR NGDTSNGVEL GKSNILLIGP
TGSGKTLLAE TLARLLDVPF TMADATTLTE AGYVGEDVEN IIQKLLQKCD YDVQKAQRGI
VYIDEIDKIS RKSDNPSITR DVSGEGVQQA LLKLIEGTVA AVPPQGGRKH PQQEFLQVDT
SKILFICGGA FAGLDKVISH RVETGSGIGF GATVKAKSDK ASEGELLAQV EPEDLIKFGL
IPEFIGRLPV VATLNELSEE ALIQILKEPK NALTKQYQAL FNLEGVDLEF RDEALDAIAK
KAMARKTGAR GLRSIVEAAL LDTMYDLPSM EDVEKVVIDE SVIDGQSKPL LIYGKPEAQQ ASGE
Length

424

Mol. Wt

46.356 kDa

pI

5.1 (calculated)

Extinction coefficient

16,390 - 17,265 (calc based on 11 Y, 0 W, and 7 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A6H1

Domain

12..51

PF06689 ClpX C4-type zinc finger

PMID:19920124[8]

Domain

110..311

PF07724 AAA domain (Cdc48 subfamily)

PMID:19920124[8]

Domain

317..408

PF10431 C-terminal, D2-small domain, of ClpB protein

PMID:19920124[8]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=clpX taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16128423

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:945083

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0001517

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P0A6H1

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10159

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10159

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:945083

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000155

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0157

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ 6.00 6.01 6.02 6.03 6.04 6.05 6.06 6.07 6.08 6.09 6.10 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ 8.0 8.1 8.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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