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Standard Name	anmK
Gene Synonym(s)	ydhH, ECK1636, b1640, JW1632^[1]^[2], JW1632
Product Desc.	anhydro-N-acetylmuramic acid kinase^[2]^[3] Anhydro-N-acetylmuramic acid kinase, murein recycling^[4]
Product Synonyms(s)	conserved protein^[1], B1640^[2]^[1], YdhH^[2]^[1], AnmK^[2]^[1] , ECK1636, JW1632, ydhH, b1640
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ydhH^[2]
Regulation/Activity
Quick Links
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</protect> See Help:Quickview for help with entering information in the Quickview table. <protect></protect>

Notes

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An anmK deletion strain grows normally.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	anmK
Mnemonic	AnhMurNAc kinase
Synonyms	ydhH, ECK1636, b1640, JW1632^[1]^[2], JW1632
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	37 minutes	MG1655: 1717626..1716517 <gbrowseImage> name=NC_000913:1716517..1717626 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1695687..1696796 <gbrowseImage> name=NC_012967:1695687..1696796 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1608576..1609685 <gbrowseImage> name=NC_012759:1608576..1609685 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1721316..1720207 <gbrowseImage> name=NC_007779:1720207..1721316 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1808197..1807088 <gbrowseImage> name=NC_010473:1807088..1808197 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔanmK789::kan					PMID:16738554	CGSC:106128
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Notes

Shown to be nonessential in E. coli ^[5]

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
	Plasmid clone	Shigen	PMID:16769691 Status: Primer 1: Primer 2:
20B5	Kohara Phage	Genobase	PMID:3038334
6F11	Kohara Phage	Genobase	PMID:3038334
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6880	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13942	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003469	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946810	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3700	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005488	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YdhH
Synonyms	conserved protein^[1], B1640^[2]^[1], YdhH^[2]^[1], AnmK^[2]^[1] , ECK1636, JW1632, ydhH, b1640
Product description	anhydro-N-acetylmuramic acid kinase^[2]^[3] Anhydro-N-acetylmuramic acid kinase, murein recycling^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0000166	nucleotide binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01270	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005338	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005524	ATP binding	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0067	F	Seeded from EcoCyc (v14.0)	complete
	GO:0005975	carbohydrate metabolic process	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0119	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006040	amino sugar metabolic process	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01270	P	Seeded from EcoCyc (v14.0)	complete
	GO:0006040	amino sugar metabolic process	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005338	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009254	peptidoglycan turnover	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01270	P	Seeded from EcoCyc (v14.0)	complete
	GO:0009254	peptidoglycan turnover	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005338	P	Seeded from EcoCyc (v14.0)	complete
	GO:0016301	kinase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GOA:hamap GO_REF:0000020	IEA: Inferred from Electronic Annotation	HAMAP:MF_01270	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005338	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GOA:spec GO_REF:0000003	IEA: Inferred from Electronic Annotation	EC:2.7.1	F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	hycF		PMID:16606699	Experiment(s):EBI-1140357
Protein	groL		PMID:16606699	Experiment(s):EBI-1140357
Protein	nohB		PMID:16606699	Experiment(s):EBI-1140357
Protein	bioC		PMID:16606699	Experiment(s):EBI-1140357
Protein	nadE		PMID:16606699	Experiment(s):EBI-1140357
Protein	hemG		PMID:16606699	Experiment(s):EBI-1140357
Protein	secD		PMID:16606699	Experiment(s):EBI-1140357
Protein	AnmK	Homodimer		Structure, analytical ultracentrifugation
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MKSGRFIGVM SGTSLDGVDV VLATIDEHRV AQLASLSWPI PVSLKQAVLD ICQGQQLTLS QFGQLDTQLG QLFADAVNAL LKEQNLQARD IVAIGCHGQT VWHEPTGVAP HTLQIGDNNQ IVARTGITVV GDFRRRDIAL GGQGAPLVPA FHHALLAHPT ERRMVLNIGG IANLSLLIPG QPVGGYDTGP GNMLMDAWIW RQAGKPYDKD AEWARAGKVI LPLLQNMLSD PYFSQPAPKS TGREYFNYGW LERHLRHFPG VDPRDVQATL AELTAVTISE QVLLSGGCER LMVCGGGSRN PLLMARLAAL LPGTEVTTTD AVGISGDDME ALAFAWLAWR TLAGLPGNLP SVTGASQETV LGAIFPANP
Length	369
Mol. Wt	39.496 kDa
pI	6.1 (calculated)
Extinction coefficient	51,450 - 51,950 (calc based on 5 Y, 8 W, and 4 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	4..367	PF03702 Uncharacterised protein family (UPF0075)		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=anmK taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

AnmK is a homodimer.

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129598	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946810	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005488	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P77570	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6880	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13942	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946810	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003469	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3700	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Reference(s)
Protein	E. coli K-12 MG1655	217	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	151	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
Protein	E. coli K-12 MG1655	214	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ydhH
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1717606..1717646 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1640 (EcoliWiki Page)	NCBI GEO profiles for anmK
microarray	GenExpDB:b1640 (EcoliWiki Page)	Summary of data for anmK from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
	GFP Fusion	Intergenic region (1717536..1717972) fused to gfpmut2.	OpenBioSystems	GFP fusion described in Zaslaver, et al. Plate:109-AZ11; Well:D3^[6]
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Notes

Accessions Related to anmK Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6880	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3700	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1640
EcoGene	EcoGene:EG13942	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003469	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005488	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Dictyostelium discoideum	DDB0186369 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000043424 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Shigella flexneri	S1799	From SHIGELLACYC
E. coli O157	Z2654	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:53067
Pfam (EcoliWiki Page)	PF03702 Uncharacterised protein family (UPF0075)
EcoCyc	EcoCyc:G6880	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13942	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003469	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3700	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0005488	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ Uehara, T et al. (2005) Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate. J. Bacteriol. 187 3643-9 PubMed
↑ Zaslaver, A et al. (2006) A comprehensive library of fluorescent transcriptional reporters for Escherichia coli. Nat. Methods 3 623-8 PubMed

anmK:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to anmK Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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