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On One Page

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Expression|

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Standard Name	abgB
Gene Synonym(s)	ECK1333, b1337, JW1331, ydaI^[1], ydaI
Product Desc.	putative p-aminobenzoyl-glutmate hydrolase^[2]^[3] Required for p-aminobenzoyl-glutamate usage^[4]
Product Synonyms(s)	predicted peptidase, aminobenzoyl-glutamate utilization protein^[1], B1337^[2]^[1], YdaI^[2]^[1], AbgB^[2]^[1] , ECK1333, JW1331, ydaI, b1337
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ogt^[2]
Regulation/Activity
Quick Links
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Notes

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abgAB expression is required for catabolism to feed p-aminobenzoate auxotrophs (Hussein, 1998; Carter, 2007). AbgAB probably catalyzes the hydrolysis of p-aminobenzoyl-glutamate to p-aminobenzoate (Carter, 2007). The abg operon is silent and an AbgR inducer has not been found (Hussein, 1998; Carter, 2007). AbgB is a member of the M20 peptidase family. abgA and abgB are paralogs.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	abgB
Mnemonic	Aminobenzoyl-glutamate
Synonyms	ECK1333, b1337, JW1331, ydaI^[1], ydaI
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	30.17 minutes	MG1655: 1401279..1399834 <gbrowseImage> name=NC_000913:1399834..1401279 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1400425..1398980 <gbrowseImage> name=NC_012967:1398980..1400425 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1291893..1293338 <gbrowseImage> name=NC_012759:1291893..1293338 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1404969..1403524 <gbrowseImage> name=NC_007779:1403524..1404969 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1490675..1489230 <gbrowseImage> name=NC_010473:1489230..1490675 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔabgB (Keio:JW1331)	deletion	deletion	PMID:16738554	Shigen CGSC9189^[5]
ΔabgB774::kan			PMID:16738554	CGSC:99878
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW1331	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCCAGGAAATCTATCGTTTTAT Primer 2:CCTTTTAAAGGTGACGGTGTCAC
3G3	Kohara Phage	Genobase	PMID:3038334
zcj-233::Tn10	Linked marker	CAG12028 = CGSC7373^[5]	est. P1 cotransduction: 29% ^[6] Synonyms:zci-233::Tn10
recT3061::Tn10	Linked marker	CAG12081 = CGSC7375^[5]	est. P1 cotransduction: 69% ^[6] Synonyms:zcj-3061::Tn10, zda-3061::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6669	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13351	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003264	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945950	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3134	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004491	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	AbgB
Synonyms	predicted peptidase, aminobenzoyl-glutamate utilization protein^[1], B1337^[2]^[1], YdaI^[2]^[1], AbgB^[2]^[1] , ECK1333, JW1331, ydaI, b1337
Product description	putative p-aminobenzoyl-glutmate hydrolase^[2]^[3] Required for p-aminobenzoyl-glutamate usage^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0006508	proteolysis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002933	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008237	metallopeptidase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002933	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011650	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046983	protein dimerization activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011650	F	Seeded from EcoCyc (v14.0)	complete
	GO:0071713	para-aminobenzoyl-glutamate hydrolase activity	PMID:17307853	IMP: Inferred from Mutant Phenotype		F		complete
	GO:0005737	cytoplasm	PMID:20190044	IDA: Inferred from Direct Assay		C		complete
	GO:0046657	folic acid catabolic process	PMID:9829935	IGI: Inferred from Genetic Interaction	EcoliWiki:pabA	P		complete
	GO:0046982	protein heterodimerization activity	PMID:20190044	IPI: Inferred from Physical Interaction	EcoliWiki:abgA	F		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	puuB	PMID:16606699	Experiment(s):EBI-1139577
Protein	yhcA	PMID:16606699	Experiment(s):EBI-1139577
Protein	rhsE	PMID:16606699	Experiment(s):EBI-1139577
Protein	gmr	PMID:16606699	Experiment(s):EBI-1139577
Protein	groL	PMID:16606699	Experiment(s):EBI-1139577
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
outer membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MQEIYRFIDD AIEADRQRYT DIADQIWDHP ETRFEEFWSA EHLASALESA GFTVTRNVGN IPNAFIASFG QGKPVIALLG EYDALAGLSQ QAGCAQPTSV TPGENGHGCG HNLLGTAAFA AAIAVKKWLE QYGQGGTVRF YGCPGEEGGS GKTFMVREGV FDDVDAALTW HPEAFAGMFN TRTLANIQAS WRFKGIAAHA ANSPHLGRSA LDAVTLMTTG TNFLNEHIIE KARVHYAITN SGGISPNVVQ AQAEVLYLIR APEMTDVQHI YDRVAKIAEG AALMTETTVE CRFDKACSSY LPNRTLENAM YQALSHFGTP EWNSEELAFA KQIQATLTSN DRQNSLNNIA ATGGENGKVF ALRHRETVLA NEVAPYAATD NVLAASTDVG DVSWKLPVAQ CFSPCFAVGT PLHTWQLVSQ GRTSIAHKGM LLAAKTMAAT TVNLFLDSGL LQECQQEHQQ VTDTQPYHCP IPKNVTPSPL K
Length	481
Mol. Wt	52.192 kDa
pI	5.6 (calculated)
Extinction coefficient	61,880 - 63,005 (calc based on 12 Y, 8 W, and 9 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	77..368	PF01546 Peptidase family M20/M25/M40		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=abgB taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129298	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945950	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004491	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P76052	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6669	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13351	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945950	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003264	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3134	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	5^a	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
Protein	E. coli K-12 MG1655	9	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	0^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ogt
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1401259..1401299 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1337 (EcoliWiki Page)	NCBI GEO profiles for abgB
microarray	GenExpDB:b1337 (EcoliWiki Page)	Summary of data for abgB from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to abgB Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6669	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3134	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1337
EcoGene	EcoGene:EG13351	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003264	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004491	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Bos taurus	ENSBTAP00000015493 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Canis familiaris	ENSCAFP00000004605 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Gallus gallus	ENSGALP00000025400 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Homo sapiens	ENSP00000275072 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Macaca mulatta	ENSMMUP00000019599 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Monodelphis domestica	ENSMODP00000022796 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Mus musculus	MGI:2685270 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Pan troglodytes	ENSPTRP00000031460 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Rattus norvegicus	ENSRNOP00000010225 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Takifugu rubripes	NEWSINFRUP00000157185 (score: 1.000; bootstrap: 100%) NEWSINFRUP00000134016 (score: 0.492)	From Inparanoid:20070104
Tetraodon nigroviridis	GSTENP00032133001 (score: 1.000; bootstrap: 100%) GSTENP00035518001 (score: 0.535)	From Inparanoid:20070104
Xenopus tropicalis	ENSXETP00000019517 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
E. coli O157	Z2427	From ECOO157CYC
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Notes

Families

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<protect> See Help:Evolution_families for help entering or editing information in this section of EcoliWiki.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01546 Peptidase family M20/M25/M40
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 CGSC: The Coli Genetics Stock Center
↑ ^6.0 ^6.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

abgB:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to abgB Expression

Notes

Links

Evolution

Homologs in Other Organisms

Notes

Families

Notes

Links

References

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