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Expression|

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Standard Name	abgA
Gene Synonym(s)	ECK1334, b1338, JW5205, ydaJ^[1], ydaJ
Product Desc.	protein with similarity to aminoacyl aminohydrolases^[2]^[3] Required for p-aminobenzoyl-glutamate utilization^[4]
Product Synonyms(s)	predicted peptidase, aminobenzoyl-glutamate utilization protein^[1], B1338^[2]^[1], YdaJ^[2]^[1], AbgA^[2]^[1] , ECK1334, JW5205, ydaJ, b1338
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): ogt^[2]
Regulation/Activity
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Notes

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abgAB expression is required for catabolism to feed p-aminobenzoate auxotrophs (Hussein, 1998; Carter, 2007). AbgAB probably catalyzes the hydrolysis of p-aminobenzoyl-glutamate to p-aminobenzoate (Carter, 2007). The abg operon is silent and an AbgR inducer has not been found (Hussein, 1998; Carter, 2007). AbgB is a member of the M20 peptidase family. abgA and abgB are paralogs.^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	abgA
Mnemonic	p-Aminobenzoyl-glutamate utilization^[5]
Synonyms	ECK1334, b1338, JW5205, ydaJ^[1], ydaJ
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	30.2 minutes	MG1655: 1402589..1401279 <gbrowseImage> name=NC_000913:1401279..1402589 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1401735..1400425 <gbrowseImage> name=NC_012967:1400425..1401735 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1293338..1294648 <gbrowseImage> name=NC_012759:1293338..1294648 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1406279..1404969 <gbrowseImage> name=NC_007779:1404969..1406279 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 1491985..1490675 <gbrowseImage> name=NC_010473:1490675..1491985 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Reference	Availability
ΔabgA (Keio:JW5205)	deletion	deletion	PMID:16738554	Shigen CGSC11237^[6]
ΔabgA775::kan			PMID:16738554	CGSC:99876
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
JW5205	Plasmid clone	Shigen	PMID:16769691 Status:Clone OK Primer 1:GCCGAGTCTTTGAATCAATTTGT Primer 2:CCGATACCTCGCGTCCAGGGAAA
3G3	Kohara Phage	Genobase	PMID:3038334
4A6	Kohara Phage	Genobase	PMID:3038334
zcj-233::Tn10	Linked marker	CAG12028 = CGSC7373^[6]	est. P1 cotransduction: 27% ^[7] Synonyms:zci-233::Tn10
recT3061::Tn10	Linked marker	CAG12081 = CGSC7375^[6]	est. P1 cotransduction: 73% ^[7] Synonyms:zcj-3061::Tn10, zda-3061::Tn10
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6670	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13352	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003265	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:945742	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3135	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004493	Escherichia coli str. K-12 substr. MG1655
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Notes

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	AbgA
Synonyms	predicted peptidase, aminobenzoyl-glutamate utilization protein^[1], B1338^[2]^[1], YdaJ^[2]^[1], AbgA^[2]^[1] , ECK1334, JW5205, ydaJ, b1338
Product description	protein with similarity to aminoacyl aminohydrolases^[2]^[3] Required for p-aminobenzoyl-glutamate utilization^[4]
EC number (for enzymes)	3.5.1.14^[1]
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 ^[1].	Missing: evidence, reference
	GO:0006508	proteolysis	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002933	P	Seeded from EcoCyc (v14.0)	complete
	GO:0008237	metallopeptidase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR002933	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011650	F	Seeded from EcoCyc (v14.0)	complete
	GO:0016787	hydrolase activity	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0378	F	Seeded from EcoCyc (v14.0)	complete
	GO:0046983	protein dimerization activity	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR011650	F	Seeded from EcoCyc (v14.0)	complete
	GO:0071713	para-aminobenzoyl-glutamate hydrolase activity	PMID:17307853	IMP: Inferred from Mutant Phenotype		F		complete
	GO:0005737	cytoplasm	PMID:20190044	IDA: Inferred from Direct Assay		C		complete
	GO:0046657	folic acid catabolic process	PMID:9829935	IGI: Inferred from Genetic Interaction	EcoliWiki:pabA	P		complete
	GO:0046982	protein heterodimerization activity	PMID:20190044	IPI: Inferred from Physical Interaction	EcoliWiki:abgB	F		complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MTGKVMESLN QFVNSLAPKL SHWRRDFHHY AESGWVEFRT ATLVAEELHQ LGYSLALGRE VVNESSRMGL PDEFTLQREF ERARQQGALA QWIAAFEGGF TGIVATLDTG RPGPVMAFRV DMDALDLSEE QDVSHRPYRD GFASCNAGMM HACGHDGHTA IGLGLAHTLK QFESGLHGVI KLIFQPAEEG TRGARAMVDA GVVDDVDYFT AVHIGTGVPA GTVVCGSDNF MATTKFDAHF TGTAAHAGAK PEDGHNALLA AAQATLALHA IAPHSEGASR VNVGVMQAGS GRNVVPASAL LKVETRGASD VINQYVFDRA QQAIQGAATM YGVGVETRLM GAATASSPSP QWVAWLQSQA AQVAGVNQAI ERVEAPAGSE DATLMMARVQ QHQGQASYVV FGTQLAAGHH NEKFDFDEQV LAIAVETLAR TALNFPWTRG I
Length	441
Mol. Wt	47.102 kDa
pI	5.8 (calculated)
Extinction coefficient	43,430 - 43,805 (calc based on 7 Y, 6 W, and 3 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	References
Domain	112..429	PF01546 Peptidase family M20/M25/M40	PMID:19920124
Domain	226..326	PF07687 Peptidase dimerisation domain	PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=abgA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:90111252	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:945742	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004493	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P77357	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G6670	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13352	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:945742	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003265	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3135	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	9	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	12	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	8^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
ogt
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:1402569..1402609 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1338 (EcoliWiki Page)	NCBI GEO profiles for abgA
microarray	GenExpDB:b1338 (EcoliWiki Page)	Summary of data for abgA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to abgA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G6670	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3135	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1338
EcoGene	EcoGene:EG13352	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003265	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004493	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Arabidopsis thaliana	AT5G56650 (score: 1.000; bootstrap: 100%) AT5G56660 (score: 0.854) AT1G51760 (score: 0.515) AT1G51780 (score: 0.499) AT1G44350 (score: 0.357) AT3G02875 (score: 0.335) AT5G54140 (score: 0.294)	From Inparanoid:20070104
Dictyostelium discoideum	DDB0204719 (score: 1.000; bootstrap: 100%)	From Inparanoid:20070104
Oryza gramene	Q5N8F2 (score: 1.000; bootstrap: 100%) Q8S9S4 (score: 0.504) Q84XG9 (score: 0.503) Q66VR4 (score: 0.487) Q5Z678 (score: 0.417) Q8H3C9 (score: 0.402) Q8H3C8 (score: 0.372) Q851L5 (score: 0.361) Q8H3C7 (score: 0.354) Q851L6 (score: 0.352) Q7XUA8 (score: 0.331)	From Inparanoid:20070104
E. coli O157	YDAJ	From ECOO157CYC
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Do-It-Yourself Web Tools

Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF01546 Peptidase family M20/M25/M40
Superfamily (EcoliWiki Page)	SUPERFAMILY:53187
Superfamily (EcoliWiki Page)	SUPERFAMILY:55031
Pfam (EcoliWiki Page)	PF07687 Peptidase dimerisation domain
EcoCyc	EcoCyc:G6670	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG13352	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003265	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB3135	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0004493	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑
↑ ^6.0 ^6.1 ^6.2 CGSC: The Coli Genetics Stock Center
↑ ^7.0 ^7.1 The Tn10 insertion sites determined by Nichols et al. 1998 (PMID:9829956) were reannotated by alignment with E. coli K-12 genome sequence (GenBank accession NC_000913). P1 contransduction frequencies were calculated using the formula of Wu (PMID:5338813).

abgA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to abgA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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