Tn3 bla:On One Page
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Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
Quickview | | Gene | | Product(s) | | Expression| | Evolution | | References | |
Quickview
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Standard Name |
Tn3 bla |
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Gene Synonym(s) | |
Product Desc. | |
Product Synonyms(s) | |
Function from GO |
<GO_nr /> |
Knock-Out Phenotype | |
Regulation/Expression | |
Regulation/Activity | |
Quick Links | |
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Notes
Gene
Nomenclature
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Standard name |
Tn3 bla |
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Mnemonic | |
Synonyms |
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Notes
Location(s) and DNA Sequence
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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.
Strain | Map location | Genome coordinates | Genome browsers | Sequence links |
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V00613: 3950..4810 |
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Notes
Sequence Features
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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.
Feature Type | Strain | Genomic Location | Evidence | Reference | Notes |
---|---|---|---|---|---|
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Notes
Alleles and Phenotypes
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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.
Allele | Nt change(s) | AA change(s) | Phenotype: Type | Phenotype: Description | Reference | Availability | Comments |
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Notes
Genetic Interactions
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Interactor | Interaction | Allele | Score(s) | Reference(s) | Accessions | Notes |
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Notes
Genetic Resources
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Resource | Resource Type | Source | Notes/Reference |
---|---|---|---|
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Notes
Accessions in Other Databases
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See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
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EcoCyc: |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene: |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB: |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE: |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP: |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
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Name | URL | Comments |
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Product(s)
Nomenclature
<protect><protect> See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Standard name |
Tn3 beta-lactamase |
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Synonyms | |
Product description | |
EC number (for enzymes) |
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Notes
Certain compounds can be added to beta-lactams to inhibit beta-lactamase.
These include: Ethylenediaminetetraacetic acid (ETDA), Clavulanic acid, and 4-Chloromercuribenzoic acid (pCMB) [2]
Function
Gene Ontology
<protect><protect> See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
---|---|---|---|---|---|---|---|---|
GO:0033250 |
penicillinase activity |
PMID:13989486 |
IDA: Inferred from Direct Assay |
F |
Table 2 shows penicillinase activity in E. Coli when placed in different penicillins. |
complete | ||
GO:0033251 |
cephalosporinase activity |
PMID:5856368 |
IDA: Inferred from Direct Assay |
F |
Table 1 shows resistance to cephalosporin in E. Coli in the presence of cephalosporinase. |
complete | ||
GO:0033250 |
penicillinase activity |
PMID:6982680 |
IDA: Inferred from Direct Assay |
F |
Table 1 shows absorbance data for slight penicillinase activity in different monobactams. |
complete | ||
GO:0046677 |
response to antibiotic |
PMID:5856368 |
IDA: Inferred from Direct Assay |
P |
Table 1 shows increased Cephalosporinase and Penicillinase activity when placed in certain antibiotics. |
complete | ||
GO:0033251 |
cephalosporinase activity |
PMID:6982680 |
IDA: Inferred from Direct Assay |
F |
Table 1 shows absorbance data for slight cephalosporinase activity in different monobactams. |
complete | ||
GO:0000345 |
cytosolic DNA-directed RNA polymerase complex |
PMID:6313485 |
IDA: Inferred from Direct Assay |
C |
Figure 2 shows transposon 3 binding at a RNA Polymerase. |
complete | ||
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Interactions
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Partner Type | Partner | Notes | References | Evidence |
---|---|---|---|---|
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Notes
Localization
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Compartment | Description | Evidence | Reference/Source | Notes |
---|---|---|---|---|
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Notes
Structure and Physical Properties
Physical Properties
<protect><protect> See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Name | |
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Sequence |
MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN SGKILESFRP EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL HNMGDHVTRL DRWEPELNEA IPNDERDTTM PAAMATTLRK LLTGELLTLA SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW |
Length |
286 |
Mol. Wt |
31.515 kDa |
pI |
5.9 (calculated) |
Extinction coefficient |
27,960 - 28,335 (calc based on 4 Y, 4 W, and 3 C residues) |
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Domains/Motifs/Modification Sites
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<motif_map/> |
Structure<protect><protect> See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
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Structure figures<protect> | |||
Notes
Gene Product Resources
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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Resource type | Source | Notes/Reference |
---|---|---|
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Notes
Accessions in Other Databases
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See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc: |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene: |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB: |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE: |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP: |
Escherichia coli str. K-12 substr. MG1655 | |
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Notes
Links
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Name | URL | Comments |
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Expression
Overview
Intracellular Levels
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See Help:Cellular levels
Molecule | Organism or Strain | Value | Units | Experimental Conditions | Assay used | Notes | Reference(s) |
---|---|---|---|---|---|---|---|
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Notes
Transcription and Transcriptional Regulation
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Notes
Translation and Regulation of Translation
Notes
Turnover and Regulation of Turnover
Notes
Experimental
Mutations Affecting Expression
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Allele Name | Mutation | Phenotype | Reference |
---|---|---|---|
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Expression Studies
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Type | Reference | Notes |
---|---|---|
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Expression Resources
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Resource Name | Resource Type | Description | Source | Notes |
---|---|---|---|---|
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Notes
Accessions Related to Tn3_bla Expression
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See Help:Gene_accessions for help with entering information into the Gene Accessions table.
Database | Accession | Notes |
---|---|---|
EcoCyc: |
Escherichia coli str. K-12 substr. MG1655 | |
EcoGene: |
Escherichia coli str. K-12 substr. MG1655 | |
RegulonDB: |
Escherichia coli str. K-12 substr. MG1655 | |
EchoBASE: |
Escherichia coli str. K-12 substr. MG1655 | |
ASAP: |
Escherichia coli str. K-12 substr. MG1655 | |
edit table |
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Notes
Links
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Name | URL | Comments |
---|---|---|
edit table |
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Evolution
Homologs in Other Organisms
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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.
Organism | Homologs (Statistics) | Comments |
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Do-It-Yourself Web Tools
Notes
Families
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See Help:Evolution_families for help entering or editing information in this section of EcoliWiki.
Database | Accession | Notes |
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Notes
Links
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Name | URL | Comments |
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- ↑ 1.0 1.1 1.2 1.3 Ayliffe, GA (1965) Cephalosporinase and penicillinase activity of Gram-negative bacteria. J. Gen. Microbiol. 40 119-26 PubMed
- ↑ Bush, K et al. (1995) A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob. Agents Chemother. 39 1211-33 PubMed