Tn3 bla:Gene Product(s)

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Gene

Gene Product(s)

Expression

Evolution

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Nomenclature

Function

Interactions

Localization

Sequence

Domains

Structure

Resources

Accessions

Links

References

Suggestions

Nomenclature

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Standard name	Tn3 beta-lactamase
Synonyms
Product description	Penicillinase, Cephalosporinase
EC number (for enzymes)
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Notes

Certain compounds can be added to beta-lactams to inhibit beta-lactamase.

These include: Ethylenediaminetetraacetic acid (ETDA), Clavulanic acid, and 4-Chloromercuribenzoic acid (pCMB)

Function

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Gene Ontology

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Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0033250	penicillinase activity	PMID:13989486	IDA: Inferred from Direct Assay		F	Table 2 shows penicillinase activity in E. Coli when placed in different penicillins.	complete
	GO:0033251	cephalosporinase activity	PMID:5856368	IDA: Inferred from Direct Assay		F	Table 1 shows resistance to cephalosporin in E. Coli in the presence of cephalosporinase.	complete
	GO:0033250	penicillinase activity	PMID:6982680	IDA: Inferred from Direct Assay		F	Table 1 shows absorbance data for slight penicillinase activity in different monobactams.	complete
	GO:0046677	response to antibiotic	PMID:5856368	IDA: Inferred from Direct Assay		P	Table 1 shows increased Cephalosporinase and Penicillinase activity when placed in certain antibiotics.	complete
	GO:0033251	cephalosporinase activity	PMID:6982680	IDA: Inferred from Direct Assay		F	Table 1 shows absorbance data for slight cephalosporinase activity in different monobactams.	complete
	GO:0000345	cytosolic DNA-directed RNA polymerase complex	PMID:6313485	IDA: Inferred from Direct Assay		C	Figure 2 shows transposon 3 binding at a RNA Polymerase.	complete
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Interactions

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Partner Type	Partner	Notes	References	Evidence
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Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Structure and Physical Properties

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Physical Properties

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Name
Sequence	MSIQHFRVAL IPFFAAFCLP VFAHPETLVK VKDAEDQLGA RVGYIELDLN SGKILESFRP EERFPMMSTF KVLLCGAVLS RVDAGQEQLG RRIHYSQNDL VEYSPVTEKH LTDGMTVREL CSAAITMSDN TAANLLLTTI GGPKELTAFL HNMGDHVTRL DRWEPELNEA IPNDERDTTM PAAMATTLRK LLTGELLTLA SRQQLIDWME ADKVAGPLLR SALPAGWFIA DKSGAGERGS RGIIAALGPD GKPSRIVVIY TTGSQATMDE RNRQIAEIGA SLIKHW
Length	286
Mol. Wt	31.515 kDa
pI	5.9 (calculated)
Extinction coefficient	27,960 - 28,335 (calc based on 4 Y, 4 W, and 3 C residues)
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Domains/Motifs/Modification Sites

<protect> See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki. Type Residues Description Notes References Domain AA 20-377 Beta Lactamase Beta lactam inhibitor UniProtID: P00811 edit table </protect>

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Structure <protect> See Help:Product_structure for help entering or editing information in this section of EcoliWiki. Structures Models edit table </protect>

Structure figures Notes Gene Product Resources [back to top] <protect> See Help:Product_resources for help with entering or editing information in this section of EcoliWiki. Resource type Source Notes/Reference edit table </protect> Notes Accessions in Other Databases [back to top] <protect> See Help:Gene_accessions for help with entering information into the Gene Accessions table. Database Accession Notes EcoCyc EcoCyc: Escherichia coli str. K-12 substr. MG1655 EcoGene EcoGene: Escherichia coli str. K-12 substr. MG1655 RegulonDB RegulonDB: Escherichia coli str. K-12 substr. MG1655 EchoBASE EchoBASE: Escherichia coli str. K-12 substr. MG1655 ASAP ASAP: Escherichia coli str. K-12 substr. MG1655 edit table </protect> Notes Links [back to top] <protect> Name URL Comments edit table </protect> References [back to top] See Help:References for how to manage references in EcoliWiki. Categories [back to top]