Phage lambda S:On One Page

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Quickview | Gene | Product(s) | Expression| Evolution | References |

Quickview

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Standard Name

Phage lambda S

Gene Synonym(s)

S, lambdap74

Product Desc.

cell lysis protein, holin, antiholin

Product Synonyms(s)

S, lambdap74

Function from GO

<GO_nr />

Knock-Out Phenotype
Regulation/Expression
Regulation/Activity
Quick Links

porteco.png

dnadisplay.png proteindisplay.png   pubmed.jpg   textpresso.jpg  

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Notes

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Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name

Phage lambda S

Mnemonic
Synonyms

S, lambdap74

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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain Map location Genome coordinates Genome browsers Sequence links

BW2952

NC_012759: 4150787..4151110
gbrowse_img.php?coord=4150787..4151110&genome=BW2952&name=NC_012759&trackset=0&width=300&.png

NC_001416

NC_001416: 45186..45509
gbrowse_img.php?coord=45186..45509&genome=bacteriophage_lambda&name=NC_001416&trackset=0&width=300&.png

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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type Strain Genomic Location Evidence Reference Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele Nt change(s) AA change(s) Phenotype: Type Phenotype: Description Reference Availability Comments

sam7

g →a on the + strand at bp 45352

 

 

 

 

 

 

strain cI857s7 ([25])

g →a on the + strand at bp 45352

 

 

 

 

 

 

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Notes

Genetic Interactions

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Interactor Interaction Allele Score(s) Reference(s) Accessions Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource Resource Type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

S

Synonyms

S, lambdap74

Product description

cell lysis protein, holin, antiholin

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status

GO:0034290

holin activity

PMID:9573208

IMP: Inferred from Mutant Phenotype

F

Fig 6.

complete

GO:0020002

host cell plasma membrane

PMID:8626053

TAS: Traceable Author Statement

C

complete

GO:0020002

host cell plasma membrane

PMID:9573208

IDA: Inferred from Direct Assay

C

Fig 4.

complete

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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes

Inner membrane


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Notes

S localizes to the membrane. During triggering of lysis, associated with loss of the proton motive force, S forms large rafts and micron sized holes[1]

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MKMPEKHDLL AAILAAKEQG IGAILAFAMA YLRGRYNGGA FTKTVIDATM CAIIAWFIRD
LLDFAGLSSN LAYITSVFIG YIGTDSIGSL IKRFAAKKAG VEDGRNQ
Length

107

Mol. Wt

11.521 kDa

pI

9.5 (calculated)

Extinction coefficient

11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes

Domain

10 - 32

Predicted membrane-spanning helix.

TMD predicted by TMHMM[2]

Domain

37 - 59

Predicted membrane-spanning helix.

TMD predicted by TMHMM[2]

Domain

69 - 91

Predicted membrane-spanning helix.

TMD predicted by TMHMM[2]

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See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

<motif_map/>

tmhmm.php?gene=Phage_lambda_S&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=Phage_lambda_S taxon=10710 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.


Cellular Levels

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See Help:Cellular levels

Molecule Organism or Strain Value Units Experimental Conditions Assay used Notes Reference(s)
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Notes

Transcription and Transcriptional Regulation

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<protect>

See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)

Phage lambda Pr' (late genes)

Phage lambda Pr' (late genes)

Phage lambda Pr' (late genes)

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_001416:45166..45206 source=bacteriophage_lambda type=CDS+DNA preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name Mutation Phenotype Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type Reference Notes
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name Resource Type Description Source Notes
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Notes

Accessions Related to Phage lambda S Expression

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Database Accession Notes
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Notes

Links

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Name URL Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism Homologs (Statistics) Comments
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Do-It-Yourself Web Tools

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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ Dewey, JS et al. (2010) Micron-scale holes terminate the phage infection cycle. Proc. Natl. Acad. Sci. U.S.A. 107 2219-23 PubMed
  2. ↑ 2.0 2.1 2.2 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

Categories

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