Phage lambda S:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

S

Synonyms

S, lambdap74

Product description

cell lysis protein, holin, antiholin

EC number (for enzymes)


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Notes

Function

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<protect> Gene Ontology See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0034290

holin activity

PMID:9573208[1]

IMP: Inferred from Mutant Phenotype

F

Fig 6.

complete

GO:0020002

host cell plasma membrane

PMID:8626053[2]

TAS: Traceable Author Statement

C

complete

GO:0020002

host cell plasma membrane

PMID:9573208[1]

IDA: Inferred from Direct Assay

C

Fig 4.

complete

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Interactions <protect> See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence
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Notes

Localization

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Compartment Description Evidence Reference/Source Notes

Inner membrane


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Notes

S localizes to the membrane. During triggering of lysis, associated with loss of the proton motive force, S forms large rafts and micron sized holes[3]

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence 
MKMPEKHDLL AAILAAKEQG IGAILAFAMA YLRGRYNGGA FTKTVIDATM CAIIAWFIRD
LLDFAGLSSN LAYITSVFIG YIGTDSIGSL IKRFAAKKAG VEDGRNQ
Length

107

Mol. Wt

11.521 kDa

pI

9.5 (calculated)

Extinction coefficient

11,460 - 11,585 (calc based on 4 Y, 1 W, and 1 C residues)

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Domains/Motifs/Modification Sites

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Type Residues Description Notes

Domain

10 - 32

Predicted membrane-spanning helix.

TMD predicted by TMHMM[4]

Domain

37 - 59

Predicted membrane-spanning helix.

TMD predicted by TMHMM[4]

Domain

69 - 91

Predicted membrane-spanning helix.

TMD predicted by TMHMM[4]

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<motif_map/>

tmhmm.php?gene=Phage_lambda_S&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
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Structures

<beststructure> gene=Phage_lambda_S taxon=10710 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes
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Notes

Links

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Name URL Comments
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References

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  1. ↑ 1.0 1.1 Smith, DL et al. (1998) Purification and biochemical characterization of the lambda holin. J. Bacteriol. 180 2531-40 PubMed
  2. ↑ Kedzierska, S et al. (1996) The Rz1 gene product of bacteriophage lambda is a lipoprotein localized in the outer membrane of Escherichia coli. Gene 168 1-8 PubMed
  3. ↑ Dewey, JS et al. (2010) Micron-scale holes terminate the phage infection cycle. Proc. Natl. Acad. Sci. U.S.A. 107 2219-23 PubMed
  4. ↑ 4.0 4.1 4.2 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

Categories

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