envZ:Gene Product(s)

Standard name	EnvZ
Synonyms	sensory histidine kinase in two-component regulatory system with OmpR^[1], B3404^[2]^[1], Tpo^[2]^[1], Kmt^[2]^[1], OmpB^[2]^[1], PerA^[2]^[1], EnvZ^[2]^[1], osmolarity sensor kinase-phosphotransferase EnvZ^[2]^[1], unphosphorylated osmolarity sensor kinase-phosphotransferase EnvZ^[2]^[1], unmodified osmolarity sensor kinase-phosphotransferase EnvZ^[2]^[1]
Product description	EnvZ^[2]^[3]; Component of EnvZ^[2]^[3] Osmosensor histidine protein kinase/phosphatase; regulates production of outer membrane proteins; dimeric^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P	Seeded from EcoCyc ^[5]	complete
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	F	Seeded from EcoCyc ^[5]	complete
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc ^[5]	complete
	GO:0016310	phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	P	Seeded from EcoCyc ^[5]	complete
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded from EcoCyc ^[5]	complete
	GO:0016021	integral to membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0812	C	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 InterPro:IPR003661 SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0007165	signal transduction	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 InterPro:IPR003661 InterPro:IPR009082	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0005524	ATP binding	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003594	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0004871	signal transducer activity	GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 InterPro:IPR009082	F	Seeded from EcoCyc ^[5]	complete
	GO:0004673	protein histidine kinase activity	GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR005467 EC:2.7.13.3	F	Seeded from EcoCyc ^[5]	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-902	P	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0000155	two-component sensor activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0006464	protein modification process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc ^[5]	complete
	GO:0005515	protein binding	PMID:11973328^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P0AA16	F	Seeded from EcoCyc ^[5]	complete
	GO:0005886	plasma membrane	GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc ^[5]	complete
	GO:0000155	two-component sensor activity	GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003661 InterPro:IPR005467	F	Seeded from EcoCyc	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0902	P	Seeded from EcoCyc	complete
	GO:0000166	nucleotide binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0547	F	Seeded from EcoCyc	complete
	GO:0004673	protein histidine kinase activity	GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR005467 EC:2.7.13.3	F	Seeded from EcoCyc	complete
	GO:0004871	signal transducer activity	GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 InterPro:IPR009082	F	Seeded from EcoCyc	complete
	GO:0005515	protein binding	PMID:11973328^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P0AA16	F	Seeded from EcoCyc	complete
	GO:0005524	ATP binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003594 SP_KW:KW-0067	F	Seeded from EcoCyc	complete
	GO:0005886	plasma membrane	GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc	complete
	GO:0007165	signal transduction	GO_REF:0000002 GO_REF:0000002 GO_REF:0000002 GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 InterPro:IPR003661 InterPro:IPR005467 InterPro:IPR009082	P	Seeded from EcoCyc	complete
	GO:0016020	membrane	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003661 SP_KW:KW-0472	C	Seeded from EcoCyc	complete
	GO:0016021	integral to membrane	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR003660 SP_KW:KW-0812	C	Seeded from EcoCyc	complete
	GO:0016301	kinase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0418	F	Seeded from EcoCyc	complete
	GO:0016310	phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	P	Seeded from EcoCyc	complete
	GO:0016740	transferase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0808	F	Seeded from EcoCyc	complete
	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR004358	F	Seeded from EcoCyc	complete
	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR005467	P	Seeded from EcoCyc	complete
	GO:0016485	protein processing				P	Seeded from EcoCyc 11.1^[3].	required fields missing
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of EnvZ	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane	C-terminus localized in the cytoplasm with 2 predicted transmembrane domains	Daley et al. (2005) ^[8]
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT EVRVEVNKSS PVVWLKTWLS PNIWVRVPLT EIHQGDFSPL FRYTLAIMLL AIGGAWLFIR IQNRPLVDLE HAALQVGKGI IPPPLREYGA SEVRSVTRAF NHMAAGVKQL ADDRTLLMAG VSHDLRTPLT RIRLATEMMS EQDGYLAESI NKDIEECNAI IEQFIDYLRT GQEMPMEMAD LNAVLGEVIA AESGYEREIE TALYPGSIEV KMHPLSIKRA VANMVVNAAR YGNGWIKVSS GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF VRGDSARTIS GTGLGLAIVQ RIVDNHNGML ELGTSERGGL SIRAWLPVPV TRAQGTTKEG
Length	450
Mol. Wt	50.334 kDa
pI	6.8 (calculated)
Extinction coefficient	61,880 - 62,005 (calc based on 12 Y, 8 W, and 1 C residues)
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Domains/Motifs/Modification Sites

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Type	Residues	Description	Notes
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<motif_map/>

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Structure
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Structures

<beststructure> gene=envZ taxon=562,83333 </beststructure>

Models

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Structure figures

Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:ENVZ-MONOMER
SwissModel (EcoliWiki Page)	SwissModel:P0AEJ4
UniProt (EcoliWiki Page)	UniProt:P0AEJ4
PFAM (EcoliWiki Page)	PFAM:PF00672
RefSeq (EcoliWiki Page)	RefSeq:NP_417863
ModBase (EcoliWiki Page)	ModBase:P0AEJ4
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.00 ^5.01 ^5.02 ^5.03 ^5.04 ^5.05 ^5.06 ^5.07 ^5.08 ^5.09 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^7.0 ^7.1 Cai, SJ & Inouye, M (2002) EnvZ-OmpR interaction and osmoregulation in Escherichia coli. J Biol Chem 277 24155-61 PubMed
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed

envZ:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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envZ:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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