fbaA:Gene Product(s)

Standard name	FbaA
Synonyms	fructose-bisphosphate aldolase, class II^[1], B2925^[2]^[1], Fda^[2]^[1], Ald^[2]^[1], FbaA^[2]^[1], Fba^[2]^[1]
Product description	fructose bisphosphate aldolase^[2]^[3]; Component of fructose bisphosphate aldolase class II^[2]^[3] Fructose-bisphosphate aldolase, class II; binds Zn(II); homdomeric^[4]
EC number (for enzymes)	4.1.2.13^[1]
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc ^[5]	complete
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F	Seeded from EcoCyc ^[5]	complete
	GO:0008270	zinc ion binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000771 SP_KW:KW-0862	F	Seeded from EcoCyc ^[5]	complete
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013785	P	Seeded from EcoCyc ^[5]	complete
	GO:0006096	glycolysis	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000771 InterPro:IPR006411 SP_KW:KW-0324	P	Seeded from EcoCyc ^[5]	complete
	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000003	IEA: Inferred from Electronic Annotation	InterPro:IPR000771 InterPro:IPR006411 EC:4.1.2.13	F	Seeded from EcoCyc 12.5 ^[6]	complete
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013785	F	Seeded from EcoCyc ^[5]	complete
	GO:0005515	protein binding	PMID:15690043^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P0A6Y8	F	Seeded from EcoCyc ^[5]	complete
	GO:0005737	cytoplasm				C	Seeded from Riley et al 2006 ^[1].	required fields missing
	GO:0003824	catalytic activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013785	F	Seeded from EcoCyc	complete
	GO:0004332	fructose-bisphosphate aldolase activity	GO_REF:0000002 GO_REF:0000002 GO_REF:0000003 PMID:16562136^[8]	IMP: Inferred from Mutant Phenotype	InterPro:IPR000771 InterPro:IPR006411 EC:4.1.2.13	F	Seeded from EcoCyc	complete
	GO:0005515	protein binding	PMID:15690043^[7]	IPI: Inferred from Physical Interaction	UniProtKB:P0A6Y8	F	Seeded from EcoCyc	complete
	GO:0006096	glycolysis	GO_REF:0000002 GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000771 InterPro:IPR006411 SP_KW:KW-0324	P	Seeded from EcoCyc	complete
	GO:0008152	metabolic process	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR013785	P	Seeded from EcoCyc	complete
	GO:0008270	zinc ion binding	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000771 SP_KW:KW-0862	F	Seeded from EcoCyc	complete
	GO:0016829	lyase activity	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0456	F	Seeded from EcoCyc	complete
	GO:0046872	metal ion binding	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0479	F	Seeded from EcoCyc	complete
	GO:0016052	carbohydrate catabolic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0004332	fructose-bisphosphate aldolase activity	PMID:16562136^[8]	IMP: Inferred from Mutant Phenotype		F		complete
	GO:0006094	gluconeogenesis				P		required field missing
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of fructose bisphosphate aldolase class II	could be indirect
Protein	dnaK		PMID:15690043^[7]	Experiment(s):EBI-879773, EBI-884401
Protein	fldA		PMID:15690043^[7]	Experiment(s):EBI-879773
Protein	hsdR		PMID:15690043^[7]	Experiment(s):EBI-879773
Protein	rpsB		PMID:15690043^[7]	Experiment(s):EBI-879773
Protein	yfeR		PMID:15690043^[7]	Experiment(s):EBI-879773
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Notes

Localization

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Compartment	Description	Evidence	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MSKIFDFVKP GVITGDDVQK VFQVAKENNF ALPAVNCVGT DSINAVLETA AKVKAPVIVQ FSNGGASFIA GKGVKSDVPQ GAAILGAISG AHHVHQMAEH YGVPVILHTD HCAKKLLPWI DGLLDAGEKH FAATGKPLFS SHMIDLSEES LQENIEICSK YLERMSKIGM TLEIELGCTG GEEDGVDNSH MDASALYTQP EDVDYAYTEL SKISPRFTIA ASFGNVHGVY KPGNVVLTPT ILRDSQEYVS KKHNLPHNSL NFVFHGGSGS TAQEIKDSVS YGVVKMNIDT DTQWATWEGV LNYYKANEAY LQGQLGNPKG EDQPNKKYYD PRVWLRAGQT SMIARLEKAF QELNAIDVL
Length	359
Mol. Wt	39.146 kDa
pI	5.8 (calculated)
Extinction coefficient	41,370 - 41,870 (calc based on 13 Y, 4 W, and 4 C residues)
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Domains/Motifs/Modification Sites

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Type	Residues	Description	Notes
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Structure
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Structures

Models

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Structure figures

Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:FRUCTBISALD-CLASSII-MONOMER
UniProt (EcoliWiki Page)	UniProt:P0AB71
PFAM (EcoliWiki Page)	PFAM:PF01116
RefSeq (EcoliWiki Page)	RefSeq:NP_417400
PDB (EcoliWiki Page)	PDB:1DOS
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
↑ ^8.0 ^8.1 Böck, A & Neidhardt, FC (1966) Isolation of a Mutant of Escherichia coli with a Temperature-sensitive Fructose-1,6-Diphosphate Aldolase Activity. J. Bacteriol. 92 464-9 PubMed

fbaA:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

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Accessions in Other Databases

Notes

Links

References

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fbaA:Gene Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

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