mutM:Gene Product(s)
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
MutM |
|---|---|
| Synonyms |
formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase[1], B3635[2][1], Fpg[2][1], MutM[2][1] |
| Product description |
formamidopyrimidine DNA glycosylase[2][3] Formamidopyrimidine-DNA glycosylase/AP lyase; 5'-terminal deoxyribophosphodiesterase; DNA repair; GC to TA; binds Zn(II)[4] |
| EC number (for enzymes) | |
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003676 |
nucleic acid binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003684 |
damaged DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0006281 |
DNA repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0006284 |
base-excision repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006289 |
nucleotide-excision repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [5] |
complete | |||
| GO:0019104 |
DNA N-glycosylase activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0008270 |
zinc ion binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000214 |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |
| GO:0008534 |
oxidized purine base lesion DNA N-glycosylase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [6] |
complete | |||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0016829 |
lyase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [5] |
complete | |||
| GO:0005737 |
cytoplasm |
C |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0016799 |
hydrolase activity, hydrolyzing N-glycosyl compounds |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000214 |
F |
Seeded from EcoCyc [5] |
complete | ||
| GO:0019104 |
DNA N-glycosylase activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc |
complete | |||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0003684 |
damaged DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0003824 |
catalytic activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0003906 |
DNA-(apurinic or apyrimidinic site) lyase activity |
GO_REF:0000020 |
IEA: Inferred from Electronic Annotation |
HAMAP:MF_00103 |
F |
Seeded from EcoCyc |
complete | |
| GO:0004519 |
endonuclease activity |
IDA: Inferred from Direct Assay |
F |
Seeded from EcoCyc |
complete | |||
| GO:0006281 |
DNA repair |
GO_REF:0000020 |
IEA: Inferred from Electronic Annotation |
HAMAP:MF_00103 |
P |
Seeded from EcoCyc |
complete | |
| GO:0006284 |
base-excision repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc |
complete | |||
| GO:0006289 |
nucleotide-excision repair |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc |
complete | |||
| GO:0006974 |
response to DNA damage stimulus |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc |
complete | |||
| GO:0008152 |
metabolic process |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc |
complete | |||
| GO:0008270 |
zinc ion binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000191 |
F |
Seeded from EcoCyc |
complete | |
| GO:0008534 |
oxidized purine base lesion DNA N-glycosylase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0016787 |
hydrolase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0016798 |
hydrolase activity, acting on glycosyl bonds |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0016799 |
hydrolase activity, hydrolyzing N-glycosyl compounds |
IEA: Inferred from Electronic Annotation |
InterPro:IPR000214 |
F |
Seeded from EcoCyc |
complete | ||
| GO:0016829 |
lyase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0046872 |
metal ion binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc |
complete | |||
| GO:0019104 |
DNA N-glycosylase activity |
IDA: Inferred from Direct Assay |
F |
complete | ||||
| GO:0004519 |
endonuclease activity |
IDA: Inferred from Direct Assay |
F |
nicking at AP sites |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
glpT |
Experiment(s):EBI-1146365 | ||
|
Protein |
thiI |
Experiment(s):EBI-1146365 | ||
|
Protein |
ilvI |
Experiment(s):EBI-1146365 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MPELPEVETS RRGIEPHLVG ATILHAVVRN GRLRWPVSEE IYRLSDQPVL SVQRRAKYLL LELPEGWIII HLGMSGSLRI LPEELPPEKH DHVDLVMSNG KVLRYTDPRR FGAWLWTKEL EGHNVLTHLG PEPLSDDFNG EYLHQKCAKK KTAIKPWLMD NKLVVGVGNI YASESLFAAG IHPDRLASSL SLAECELLAR VIKAVLLRSI EQGGTTLKDF LQSDGKPGYF AQELQVYGRK GEPCRVCGTP IVATKHAQRA TFYCRQCQK |
|---|---|
| Length |
269 |
| Mol. Wt |
30.29 kDa |
| pI |
8.6 (calculated) |
| Extinction coefficient |
39,420 - 40,170 (calc based on 8 Y, 5 W, and 6 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
| Structures |
<beststructure>mutM 562</beststructure> |
|---|---|
| Models |
View models at: |
| edit table |
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 7.0 7.1 7.2 7.3 7.4 O'Connor, TR & Laval, J (1989) Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc. Natl. Acad. Sci. U.S.A. 86 5222-6 PubMed
- ↑ 8.0 8.1 8.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
Categories
- GO:0003676 ! nucleic acid binding
- GO:0003677 ! DNA binding
- GO:0003684 ! damaged DNA binding
- GO:0003824 ! catalytic activity
- GO:0003906 ! DNA-(apurinic or apyrimidinic site) endonuclease activity
- GO:0006281 ! DNA repair
- GO:0006284 ! base-excision repair
- GO:0006289 ! nucleotide-excision repair
- GO:0006974 ! cellular response to DNA damage stimulus
- GO:0019104 ! DNA N-glycosylase activity
- GO:0008270 ! zinc ion binding
- GO:0008534 ! oxidized purine nucleobase lesion DNA N-glycosylase activity
- GO:0016787 ! hydrolase activity
- GO:0016798 ! hydrolase activity, acting on glycosyl bonds
- GO:0016829 ! lyase activity
- GO:0046872 ! metal ion binding
- GO:0005737 ! cytoplasm
- GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds
- GO:0004519 ! endonuclease activity
- GO:0008152 ! metabolic process
- Proteins
- Products with structures in PDB