lacI:Gene Product(s)
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
LacI |
|---|---|
| Synonyms |
DNA-binding transcriptional repressor[1], B0345[2][1], LacI[2][1], transcriptional repressor of the lac operon[2][1] |
| Product description |
LacI transcriptional repressor[2][3] Transcriptional repressor of lac operon[4] |
| EC number (for enzymes) |
|
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0005515 |
protein binding |
IPI: Inferred from Physical Interaction |
F |
Seeded from EcoCyc [6] |
complete | |||
| GO:0003677 |
DNA binding |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [6] |
complete | |||
| GO:0003700 |
transcription factor activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc [6] |
complete | |||
| GO:0005622 |
intracellular |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc [6] |
complete | |||
| GO:0006350 |
transcription |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [6] |
complete | |||
| GO:0005829 |
cytosol |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc [6] |
complete | |||
| GO:0016564 |
transcription repressor activity |
F |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0005737 |
cytoplasm |
C |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0016052 |
carbohydrate catabolic process |
P |
Seeded from EcoCyc 11.1[3]. |
required fields missing | ||||
| GO:0006355 |
regulation of transcription, DNA-dependent |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc [6] |
complete | |||
| edit table |
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
lacZ |
Experiment(s):EBI-1136310 | ||
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
|
cytoplasm |
From EcoCyc[3] | ||
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Sequence |
MKPVTLYDVA EYAGVSYQTV SRVVNQASHV SAKTREKVEA AMAELNYIPN RVAQQLAGKQ SLLIGVATSS LALHAPSQIV AAIKSRADQL GASVVVSMVE RSGVEACKAA VHNLLAQRVS GLIINYPLDD QDAIAVEAAC TNVPALFLDV SDQTPINSII FSHEDGTRLG VEHLVALGHQ QIALLAGPLS SVSARLRLAG WHKYLTRNQI QPIAEREGDW SAMSGFQQTM QMLNEGIVPT AMLVANDQMA LGAMRAITES GLRVGADISV VGYDDTEDSS CYIPPLTTIK QDFRLLGQTS VDRLLQLSQG QAVKGNQLLP VSLVKRKTTL APNTQTASPR ALADSLMQLA RQVSRLESGQ |
|---|---|
| Mol. Wt |
38.59 kDa (calc) [2] |
| pI |
6.7[2] |
| Extinction coefficient |
22920 - 23295 (calc based on 8 Y, 2 W, and 3 C residues) |
| edit table |
Domains/Motifs/Modification Sites
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
| Type | Residues | Description | Notes |
|---|---|---|---|
|
Domain |
1 - 58 |
||
| edit table |
Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
| Structures |
<beststructure>lacI 562</beststructure> |
|---|---|
| Models |
View models at: |
| edit table |
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
- ↑ Lasserre, JP et al. (2006) A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Electrophoresis 27 3306-21 PubMed
Categories
- GO:0005515 ! protein binding
- GO:0003677 ! DNA binding
- GO:0003700 ! DNA-binding transcription factor activity
- GO:0005622 ! intracellular
- GO:0006350 ! transcription
- GO:0005829 ! cytosol
- GO:0016564 ! obsolete transcription repressor activity
- GO:0005737 ! cytoplasm
- GO:0016052 ! carbohydrate catabolic process
- GO:0006355 ! regulation of transcription, DNA-templated
- Proteins
- GO:0016564 ! transcription repressor activity
- Location:cytoplasm
- Products with structures in PDB