prs:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

PrsA

Synonyms

phosphoribosylpyrophosphate synthase[1], B1207[2][1], DnaR[2][1], Prs[2][1], PrsA[2][1]

Product description

Phosphoribosylpyrophosphate synthase[3]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

F

Seeded from EcoCyc (v14.0)

complete

GO:0000287

magnesium ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0460

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

F

Seeded from EcoCyc (v14.0)

complete

GO:0004749

ribose phosphate diphosphokinase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.6.1

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0009116

nucleoside metabolic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000836

P

Seeded from EcoCyc (v14.0)

complete

GO:0009156

ribonucleoside monophosphate biosynthetic process

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00583

P

Seeded from EcoCyc (v14.0)

complete

GO:0009156

ribonucleoside monophosphate biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000842

P

Seeded from EcoCyc (v14.0)

complete

GO:0009165

nucleotide biosynthetic process

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005946

P

Seeded from EcoCyc (v14.0)

complete

GO:0009165

nucleotide biosynthetic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0545

P

Seeded from EcoCyc (v14.0)

complete

GO:0016301

kinase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0418

F

Seeded from EcoCyc (v14.0)

complete

GO:0016740

transferase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0808

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

npdA

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-881344, EBI-885898

Protein

dnaJ

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

dnaK

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

groL

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

mreB

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplB

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rplE

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplJ

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

rplP

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsB

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsC

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsD

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rpsG

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

tufA

PMID:15690043[4]

Experiment(s):EBI-880430, EBI-885898

Protein

rluB

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

yibA

PMID:15690043[4]

Experiment(s):EBI-880430

Protein

nusG

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rho

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplC

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplD

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplI

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplK

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplL

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplM

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplN

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplO

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplS

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplU

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplV

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplW

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rplX

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpmB

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsE

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsH

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsJ

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsP

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

rpsT

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

yfiF

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

yrfD

PMID:15690043[4]

Experiment(s):EBI-885898

Protein

groL

PMID:16606699[5]

Experiment(s):EBI-1139177

Protein

groL

PMID:19402753[6]

LCMS(ID Probability):99.6 MALDI(Z-score):17.053160

Protein

groS

PMID:19402753[6]

LCMS(ID Probability):99.0 MALDI(Z-score):17.053160

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MPDMKLFAGN ATPELAQRIA NRLYTSLGDA AVGRFSDGEV SVQINENVRG GDIFIIQSTC
APTNDNLMEL VVMVDALRRA SAGRITAVIP YFGYARQDRR VRSARVPITA KVVADFLSSV
GVDRVLTVDL HAEQIQGFFD VPVDNVFGSP ILLEDMLQLN LDNPIVVSPD IGGVVRARAI
AKLLNDTDMA IIDKRRPRAN VSQVMHIIGD VAGRDCVLVD DMIDTGGTLC KAAEALKERG
AKRVFAYATH PIFSGNAANN LRNSVIDEVV VCDTIPLSDE IKSLPNVRTL TLSGMLAEAI
RRISNEESIS AMFEH
Length

315

Mol. Wt

34.218 kDa

pI

5.2 (calculated)

Extinction coefficient

5,960 - 6,460 (calc based on 4 Y, W, and 4 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A717

Domain

149..250

PF00156 Phosphoribosyl transferase domain

PMID:19920124[7]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=prs taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:PRPPSYN-MONOMER

SwissModel (EcoliWiki Page)

SwissModel:P0A717

UniProt (EcoliWiki Page)

UniProt:P0A717

PFAM (EcoliWiki Page)

Pfam:P0A717

RefSeq (EcoliWiki Page)

RefSeq:NP_415725


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  4. ↑ 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 4.11 4.12 4.13 4.14 4.15 4.16 4.17 4.18 4.19 4.20 4.21 4.22 4.23 4.24 4.25 4.26 4.27 4.28 4.29 4.30 4.31 4.32 4.33 4.34 4.35 4.36 4.37 4.38 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  5. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  6. ↑ 6.0 6.1 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  7. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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