dnaA:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DnaA

Synonyms

chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator[1], B3702[2][1], DnaA[2][1], DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator[2][1]

Product description

DnaA transcriptional dual regulator[2][3]

DNA synthesis initiator and global transcription regulator; binds DNA at DnaA boxes, binds cardiolipin and other acidic phospholipids, binds ATP[4]

EC number (for enzymes)


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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc [5]

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010921
InterPro:IPR013159

F

Seeded from EcoCyc [5]

complete

GO:0006275

regulation of DNA replication

GO_REF:0000002
GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001957
InterPro:IPR013159
HAMAP:MF_00377

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0006260

DNA replication<input name="field[2]" type="hidden" value="DNA replication" />

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0235

P

Seeded from EcoCyc [5]

complete

GO:0006270

DNA replication initiation

GO_REF:0000002
GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001957
InterPro:IPR013159
HAMAP:MF_00377

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0005524

ATP binding

GO_REF:0000002
GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001957
InterPro:IPR013159
SP_KW:KW-0067
HAMAP:MF_00377

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0000166

nucleotide binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003593
SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

GO:0003677

DNA binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001957
SP_KW:KW-0238

F

Seeded from EcoCyc [5]

complete

GO:0003688

DNA replication origin binding

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001957
HAMAP:MF_00377

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0006261

DNA-dependent DNA replication

PMID:2839499[7]

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc 11.1[3].

complete

GO:0006350

transcription

P

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016564

transcription repressor activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

GO:0016563

transcription activator activity

F

Seeded from EcoCyc 11.1[3].

required fields missing

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aspS

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

cca

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

dnaJ

PMID:15690043[8]

Experiment(s):EBI-883418, EBI-890702

Protein

lpdA

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

nadE

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

rplB

PMID:15690043[8]

Experiment(s):EBI-883418, EBI-890702

Protein

rplD

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

rpsB

PMID:15690043[8]

Experiment(s):EBI-883418, EBI-890702

Protein

tufA

PMID:15690043[8]

Experiment(s):EBI-883418

Protein

rpsI

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

yfdS

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

yibL

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

rpsG

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

groL

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

dgt

PMID:16606699[9]

Experiment(s):EBI-1146527

Protein

creC

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplC

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplL

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplN

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplO

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplP

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplV

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplW

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rplX

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpmB

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsC

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsE

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsG

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsI

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsJ

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsM

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsN

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

rpsT

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

ynhG

PMID:15690043[8]

Experiment(s):EBI-890702

Protein

Dps

PMID:18284581[10]

Affinity chromatography and solid phase binding assay

Protein

Hda

PMID:11483528[11]


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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
GLLTSFCGAD APQLRFEVGT KPVTQTPQAA VTSNVAAPAQ VAQTQPQRAA PSTRSGWDNV
PAPAEPTYRS NVNVKHTFDN FVEGKSNQLA RAAARQVADN PGGAYNPLFL YGGTGLGKTH
LLHAVGNGIM ARKPNAKVVY MHSERFVQDM VKALQNNAIE EFKRYYRSVD ALLIDDIQFF
ANKERSQEEF FHTFNALLEG NQQIILTSDR YPKEINGVED RLKSRFGWGL TVAIEPPELE
TRVAILMKKA DENDIRLPGE VAFFIAKRLR SNVRELEGAL NRVIANANFT GRAITIDFVR
EALRDLLALQ EKLVTIDNIQ KTVAEYYKIK VADLLSKRRS RSVARPRQMA MALAKELTNH
SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN LIRTLSS
Length

467

Mol. Wt

52.551 kDa

pI

8.9 (calculated)

Extinction coefficient

43,890 - 44,265 (calc based on 11 Y, 5 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dnaA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:PD03831

SwissModel (EcoliWiki Page)

SwissModel:P03004

UniProt (EcoliWiki Page)

UniProt:P03004

RefSeq (EcoliWiki Page)

RefSeq:NP_418157


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 3.2 3.3 3.4 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 6.3 6.4 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Hwang, DS & Kaguni, JM (1988) Purification and characterization of the dnaA46 gene product. J. Biol. Chem. 263 10625-32 PubMed
  8. ↑ 8.00 8.01 8.02 8.03 8.04 8.05 8.06 8.07 8.08 8.09 8.10 8.11 8.12 8.13 8.14 8.15 8.16 8.17 8.18 8.19 8.20 8.21 8.22 8.23 8.24 8.25 8.26 8.27 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  9. ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  10. ↑ Chodavarapu, S et al. (2008) Escherichia coli Dps interacts with DnaA protein to impede initiation: a model of adaptive mutation. Mol. Microbiol. 67 1331-46 PubMed
  11. ↑ Kato , J & Katayama, T (2001) Hda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coli. EMBO J. 20 4253-62 PubMed

Categories

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