recA:Gene Product(s)

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

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Standard name

RecA

Synonyms

B2699[1][2], Tif[1][2], UmuB[1][2], Zab[1][2], Srf[1][2], RnmB[1][2], RecH[1][2], LexB[1][2], RecA[1][2]

Product description

DNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease[1]; DNA strand exchange and recombination protein with protease and nuclease activity[3]

General recombination and DNA repair; pairing and strand exchange; role in cleavage of LexA repressor, SOS mutagenesis[4]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0017111

nucleoside-triphosphatase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc [5]

complete

GO:0009432

SOS response

PMC2832678

IDA: Inferred from Direct Assay

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0008094

DNA-dependent ATPase activity

GO_REF:0000002
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001553
HAMAP:MF_00268

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0006974

response to DNA damage stimulus

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227
HAMAP:MF_00268

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0006950

response to stress

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0346

P

Seeded from EcoCyc [5]

complete

GO:0006310

DNA recombination

GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0233
HAMAP:MF_00268

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0006281

DNA repair

GO_REF:0000004
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234
SP_KW:KW-0742
HAMAP:MF_00268

P

Seeded from EcoCyc 12.5 [6]

complete

GO:0006259

DNA metabolic process

GO_REF:0000002

IEA: Inferred from Electronic Annotation

P

Seeded from EcoCyc [5]

complete

GO:0005737

cytoplasm

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc 12.5 [6]

complete

GO:0005524

ATP binding

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR001553
SP_KW:KW-0067
HAMAP:MF_00268

F

Seeded from EcoCyc 12.5 [6]

complete

GO:0003697

single-stranded DNA binding

GO_REF:0000020 PMID:19820696[7]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc [5]

complete

GO:0003684

damaged DNA binding

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00268

F

Seeded from EcoCyc [5]

complete

GO:0003677

DNA binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR001553
SP_KW:KW-0238

F

Seeded from EcoCyc [5]

complete

GO:0000166

nucleotide binding

GO_REF:0000002
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003593
SP_KW:KW-0547

F

Seeded from EcoCyc [5]

complete

Under review

GO:0008233

peptidase activity

F

Seeded from EcoCyc 11.1[3].

required field missing

GO:0046105

thymidine biosynthetic process

PMC2832678

IMP: Inferred from Mutant Phenotype

P

Figure 1

complete

GO:0006974

response to DNA damage stimulus

PMID:10760155[8]

IEP: Inferred from Expression Pattern

P

complete

GO:0006508

proteolysis

PMID:6231641[9]

IDA: Inferred from Direct Assay

P

Figure 1

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

napC

PMID:16606699[10]

Experiment(s):EBI-1143694

Protein

rplJ

PMID:16606699[10]

Experiment(s):EBI-1143694

Protein

nadE

PMID:16606699[10]

Experiment(s):EBI-1143694

Protein

rplB

PMID:16606699[10]

Experiment(s):EBI-1143694

Protein

yfiR

PMID:16606699[10]

Experiment(s):EBI-1143694
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAIDENKQKA LAAALGQIEK QFGKGSIMRL GEDRSMDVET ISTGSLSLDI ALGAGGLPMG
RIVEIYGPES SGKTTLTLQV IAAAQREGKT CAFIDAEHAL DPIYARKLGV DIDNLLCSQP
DTGEQALEIC DALARSGAVD VIVVDSVAAL TPKAEIEGEI GDSHMGLAAR MMSQAMRKLA
GNLKQSNTLL IFINQIRMKI GVMFGNPETT TGGNALKFYA SVRLDIRRIG AVKEGENVVG
SETRVKVVKN KIAAPFKQAE FQILYGEGIN FYGELVDLGV KEKLIEKAGA WYSYKGEKIG
QGKANATAWL KDNPETAKEI EKKVRELLLS NPNSTPDFSV DDSEGVAETN EDF
Length

353

Mol. Wt

37.974 kDa

pI

5.0 (calculated)

Extinction coefficient

21,430 - 21,805 (calc based on 7 Y, 2 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P0A7G6


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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=recA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:EG10823-MONOMER

UniProt (EcoliWiki Page)

UniProt:P0A7G6

PFAM (EcoliWiki Page)

PFAM:PF00154

RefSeq (EcoliWiki Page)

RefSeq:NP_417179


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Roy, R et al. (2009) SSB protein diffusion on single-stranded DNA stimulates RecA filament formation. Nature 461 1092-7 PubMed
  8. ↑ Fernández De Henestrosa, AR et al. (2000) Identification of additional genes belonging to the LexA regulon in Escherichia coli. Mol. Microbiol. 35 1560-72 PubMed
  9. ↑ Little, JW (1984) Autodigestion of lexA and phage lambda repressors. Proc. Natl. Acad. Sci. U.S.A. 81 1375-9 PubMed
  10. ↑ 10.0 10.1 10.2 10.3 10.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed

Categories

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