recA:Quickview

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
References Suggestions

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Standard Name

recA

Gene Synonym(s)

ECK2694, b2699, JW2669, lexB, srf, umuB, zab, recH, rnmB, tif, umuR[1], umuR

Product Desc.

DNA strand exchange and renaturation, DNA-dependent ATPase, DNA- and ATP-dependent coprotease[2]; DNA strand exchange and recombination protein with protease and nuclease activity[3]

General recombination and DNA repair; pairing and strand exchange; role in cleavage of LexA repressor, SOS mutagenesis[4]

Product Synonyms(s)

B2699[2][1], Tif[2][1], UmuB[2][1], Zab[2][1], Srf[2][1], RnmB[2][1], RecH[2][1], LexB[2][1], RecA[2][1] , ECK2694, JW2669, lexB, recH, rnmB, srf, tif, umuB, umuR, zab, b2699

Function from GO

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Knock-Out Phenotype
Regulation/Expression

transcription unit(s): recAX[2], recA[2], OP00086

Regulation/Activity
Quick Links

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Notes

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RecA does not bind to DNA with extensive stem-loop structures, except in the presence of SSB. RecA is required for polV lesion bypass. RecA filamentation is inhibited by RecX. Binds TrxA (Kumar, 2004).[4]

RecA lacking mutants exhibited the same frequency as the wild type when exposed to sublethal concentrations of the antibiotics Ampicillin, Ceftazidime, Imipenem, Fosfomycin, Ciprofloxacin, Trimethoprim, and Sulfamethoxazole.(PMID:21212055)

RecA lacking mutants exhibited different frequencies then the wild type when exposed to sublethal concentrations of the antibiotics Gentamicin, Rifampicin, Chloramphenicol (PMID:21212055)



References

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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. 4.0 4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.