arsB:Gene Product(s): Difference between revisions

Standard name	ArsB
Synonyms	arsenite/antimonite transporter^[1], B3502^[2]^[1], ArsF^[2]^[1], F172^[2]^[1]
Product description	ArsB^[2]^[3]; Component of arsenate Ars transporter^[2]^[3] Arsenite pump, inner membrane; resistance to arsenate, arsenite, and antimonite^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference(s)	Evidence Code	with/from	Aspect	Notes	Status
	GO:0016020	membrane	GO_REF:0000004 GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0397 SP_KW:KW-0472	C	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0016021	integral to membrane	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000802 SP_KW:KW-0812	C	Seeded from EcoCyc ^[6]	complete
	GO:0008490	arsenite secondary active transmembrane transporter activity	PMID:14970228^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc ^[6]	complete
	GO:0015699	antimonite transport	PMID:14970228^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc ^[6]	complete
	GO:0015700	arsenite transport	PMID:14970228^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc ^[6]	complete
	GO:0042960	antimonite secondary active transmembrane transporter activity	PMID:14970228^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc ^[6]	complete
	GO:0046685	response to arsenic	PMID:7860609^[8]	IEP: Inferred from Expression Pattern		P	Seeded from EcoCyc 12.5 ^[5]	complete
	GO:0005886	plasma membrane	GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc ^[6]	complete
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc ^[6]	complete
	GO:0015105	arsenite transmembrane transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000802	F	Seeded from EcoCyc ^[6]	complete
	GO:0005886	plasma membrane	GO_REF:0000004 GO_REF:0000004 GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_KW:KW-0997 SP_KW:KW-1003 SP_SL:SL-0037	C	Seeded from EcoCyc	complete
	GO:0006810	transport	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0813	P	Seeded from EcoCyc	complete
	GO:0008490	arsenite secondary active transmembrane transporter activity	PMID:14970228^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc	complete
	GO:0015105	arsenite transmembrane transporter activity	GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR000802	F	Seeded from EcoCyc	complete
	GO:0015699	antimonite transport	PMID:14970228^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc	complete
	GO:0015700	arsenite transport	PMID:14970228^[7]	IDA: Inferred from Direct Assay		P	Seeded from EcoCyc	complete
	GO:0016020	membrane	GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0472	C	Seeded from EcoCyc	complete
	GO:0016021	integral to membrane	GO_REF:0000002 GO_REF:0000004	IEA: Inferred from Electronic Annotation	InterPro:IPR000802 SP_KW:KW-0812	C	Seeded from EcoCyc	complete
	GO:0042960	antimonite secondary active transmembrane transporter activity	PMID:14970228^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc	complete
	GO:0006805	xenobiotic metabolic process				P	Seeded from EcoCyc 11.1^[3].	required fields missing
	GO:0046685	response to arsenic	GO_REF:0000004 PMID:7860609^[8]	IEP: Inferred from Expression Pattern	SP_KW:KW-0059	P	Seeded from EcoCyc	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	Notes	References	Evidence
Protein	Subunits of arsenate Ars transporter	could be indirect
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Notes
plasma membrane	C-terminus localized to the periplasm with 11 predicted transmembrane domains	Daley et al. (2005) ^[9]
plasma membrane			From EcoCyc^[3]
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence	at EcoCyc MFYPGGIMLL AGAIFVLTIV LVIWQPKGLG IGWSATLGAV LALVTGVVHP GDIPVVWNIV WNATAAFIAV IIISLLLDES GFFEWAALHV SRWGNGRGRL LFTWIVLLGA AVAALFANDG AALILTPIVI AMLLALGFSK GTTLAFVMAA GFIADTASLP LIVSNLVNIV SADFFGLGFR EYASVMVPVD IAAIVATLVM LHLYFRKDIP QNYDMALLKS PAEAIKDPAT FKTGWVVLLL LLVGFFVLEP LGIPVSAIAA VGALILFVVA KRGHAINTGK VLRGAPWQIV IFSLGMYLVV YGLRNAGLTE YLSGVLNVLA DNGLWAATLG TGFLTAFLSS IMNNMPTVLV GALSIDGSTA SGVIKEAMVY ANVIGCDLGP KITPIGSLAT LLWLHVLSQK NMTISWGYYF RTGIIMTLPV LFVTLAALAL RLSFTL
Length	436
Mol. Wt	45.5 kDa (calc) ^[2]
pI
Extinction coefficient	80900 - 81025 (calc based on 10 Y, 12 W, and 1 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes
Domain	412 - 434	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	284 - 303	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	315 - 337	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	182 - 204	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	235 - 269	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	98 - 117	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	121 - 138	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	145 - 167	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	29 - 51	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	55 - 77	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
Domain	5 - 24	Predicted membrane-spanning helix.	TMD predicted by TMHMM^[10]
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<motif_map/>

Click the image to view raw output from TMHMM.

Structure See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

Models

View models at:

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc (EcoliWiki Page)	EcoCyc:ARSF-MONOMER
UniProt (EcoliWiki Page)	UniProt:P0AB93
PFAM (EcoliWiki Page)	PFAM:PF02040
RefSeq (EcoliWiki Page)	RefSeq:NP_417959
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Notes

Links

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Name	URL	Comments
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References

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↑ ^1.0 ^1.1 ^1.2 ^1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 ^3.2 ^3.3 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ ^5.0 ^5.1 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 EcoCyc (release 13.0; 2009) Keseler, IM et al. (2009) Nucleic Acids Res. 37(Database issue):D464-70
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Meng, YL et al. (2004) As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli. J. Biol. Chem. 279 18334-41 PubMed
↑ ^8.0 ^8.1 Carlin, A et al. (1995) The ars operon of Escherichia coli confers arsenical and antimonial resistance. J. Bacteriol. 177 981-6 PubMed
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 Krogh, A et al. (2001) Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. J. Mol. Biol. 305 567-80 PubMed

arsB:Gene Product(s): Difference between revisions

Revision as of 22:18, 21 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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 C
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+Seeded from EcoCyc
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+complete
+|-
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+GO:0042960
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+antimonite secondary active transmembrane transporter activity
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+PMID:14970228
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+IDA: Inferred from Direct Assay
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+F
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 Seeded from EcoCyc
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-GO:0042960
+GO:0046685
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-antimonite secondary active transmembrane transporter activity
+response to arsenic
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-PMID:14970228
+GO_REF:0000004<br />PMID:7860609
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-IDA: Inferred from Direct Assay
+IEP: Inferred from Expression Pattern
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+SP_KW:KW-0059<br />
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-F
+P
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 Seeded from EcoCyc

arsB:Gene Product(s): Difference between revisions

Revision as of 22:18, 21 May 2009

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

References

Categories

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