PMID:7860609
| Citation |
Carlin, A, Shi, W, Dey, S and Rosen, BP (1995) The ars operon of Escherichia coli confers arsenical and antimonial resistance. J. Bacteriol. 177:981-6 |
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| Abstract |
The chromosomally encoded arsenical resistance (ars) operon subcloned into a multicopy plasmid was found to confer a moderate level of resistance to arsenite and antimonite in Escherichia coli. When the operon was deleted from the chromosome, the cells exhibited hypersensitivity to arsenite, antimonite, and arsenate. Expression of the ars genes was inducible by arsenite. By Southern hybridization, the operon was found in all strains of E. coli examined but not in Salmonella typhimurium, Pseudomonas aeruginosa, or Bacillus subtilis. |
| Links | |
| Keywords |
Adenosine Triphosphatases/genetics; Antimony/pharmacology; Arsenates/pharmacology; Arsenite Transporting ATPases; Arsenites/pharmacology; Bacterial Proteins; Biological Transport; Chromosomes, Bacterial/genetics; Cloning, Molecular; Drug Resistance, Microbial/genetics; Energy Metabolism; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial/genetics; Ion Pumps; Multienzyme Complexes; Operon/genetics; Plasmids/genetics; Sequence Deletion; Trans-Activators/genetics |
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