dipZ:Gene Product(s): Difference between revisions

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Table edited by Ap26526 via TableEdit
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IEP: Inferred from Expression Pattern
IEP: Inferred from Expression Pattern
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P
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complete
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GO:0042493
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response to drug
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PMID:7628442
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IMP: Inferred from Mutant Phenotype
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Revision as of 21:33, 2 May 2010

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Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DsbD

Synonyms

B4136[1][2], HtrI[1][2], CycZ[1][2], DipZ

Product description

fused thiol:disulfide interchange protein[3]: membrane electron transporter[4]: activator of DsbC[2]

EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki. See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference(s) Evidence Code with/from Aspect Notes Status
GO:0047134

protein-disulfide reductase activity

GO_REF:0000003
GO_REF:0000020

IEA: Inferred from Electronic Annotation

EC:1.8.1.8
HAMAP:MF_00399

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0045454

cell redox homeostasis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR006662

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0017004

cytochrome complex assembly

GO_REF:0000002
GO_REF:0000004
GO_REF:0000020

IEA: Inferred from Electronic Annotation

InterPro:IPR003834
SP_KW:KW-0201
HAMAP:MF_00399

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0016491

oxidoreductase activity

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0560

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0016021

integral to membrane

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0812

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0016020

membrane

GO_REF:0000002
GO_REF:0000004
GO_REF:0000004

IEA: Inferred from Electronic Annotation

InterPro:IPR003834
SP_KW:KW-0397
SP_KW:KW-0472

C

Seeded from EcoCyc 12.5 [5]

complete

GO:0009055

electron carrier activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00399

F

Seeded from EcoCyc 12.5 [5]

complete

GO:0006810

transport

GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0813

P

Seeded from EcoCyc 12.5 [5]

complete

GO:0006790

sulfur metabolic process

P

Seeded from EcoCyc 11.1[6].

required fields missing

GO:0005887

integral to plasma membrane

PMID:19258316[7]

IDA: Inferred from Direct Assay

C

complete

GO:0017004

cytochrome complex assembly

PMID:7957865[8]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006950

response to stress

PMID:7628442[3]

IEP: Inferred from Expression Pattern

P

complete

GO:0042493

response to drug

PMID:7628442[3]

IMP: Inferred from Mutant Phenotype

P

complete

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Interactions

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Partner Type Partner Notes References Evidence
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Source Notes

Inner membrane

N- and C-terminal two soluble domains localized to the periplasm with central 8 transmembrane segment domains

PMID:10712691[9] PMID:10545108[10]

plasma membrane

From EcoCyc[6]


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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Sequence

at EcoCyc 

MAQRIFTLIL LLCSTSVFAG LFDAPGRSQF VPADQAFAFD FQQNQHDLNL TWQIKDGYYL
YRKQIRITPE HAKIADVQLP QGVWHEDEFY GKSEIYRDRL TLPVTINQAS AGATLTVTYQ
GCADAGFCYP PETKTVPLSE VVANNAAPQP VSVPQQEQPT AQLPFSALWA LLIGIGIAFT
PCVLPMYPLI SGIVLGGKQR LSTARALLLT FIYVQGMALT YTALGLVVAA AGLQFQAALQ
HPYVLIGLAI VFTLLAMSMF GLFTLQLPSS LQTRLTLMSN RQQGGSPGGV FVMGAIAGLI
CSPCTTAPLS AILLYIAQSG NMWLGGGTLY LYALGMGLPL MLITVFGNRL LPKSGPWMEQ
VKTAFGFVIL ALPVFLLERV IGDVWGLRLW SALGVAFFGW AFITSLQAKR GWMRIVQIIL
LAAALVSVRP LQDWAFGATH TAQTQTHLNF TQIKTVDELN QALVEAKGKP VMLDLYADWC
VACKEFEKYT FSDPQVQKAL ADTVLLQANV TANDAQDVAL LKHLNVLGLP TILFFDGQGQ
EHPQARVTGF MDAETFSAHL RDRQP
Length

565

Mol. Wt

61.796 kDa

pI

7.1 (calculated)

Extinction coefficient

84,340 - 85,340 (calc based on 16 Y, 11 W, and 8 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

motif

1-19

UniProt Manual:Signal Peptides

UniProt:P36655


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<motif_map/>

tmhmm.php?gene=dsbD&show=pic&.jpg
Click the image to view raw output from TMHMM.

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dipZ taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

EcoCyc (EcoliWiki Page)

EcoCyc:DSBD-MONOMER

UniProt (EcoliWiki Page)

UniProt:P36655

PFAM (EcoliWiki Page)

PFAM:PF02683

RefSeq (EcoliWiki Page)

RefSeq:NP_418559


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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  3. ↑ 3.0 3.1 3.2 Missiakas, D et al. (1995) Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J. 14 3415-24 PubMed
  4. ↑ Rietsch, A et al. (1996) An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 93 13048-53 PubMed
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  6. ↑ 6.0 6.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  7. ↑ Cho, SH & Beckwith, J (2009) Two snapshots of electron transport across the membrane: insights into the structure and function of DsbD. J. Biol. Chem. 284 11416-24 PubMed
  8. ↑ Sambongi, Y & Ferguson, SJ (1994) Specific thiol compounds complement deficiency in c-type cytochrome biogenesis in Escherichia coli carrying a mutation in a membrane-bound disulphide isomerase-like protein. FEBS Lett. 353 235-8 PubMed
  9. ↑ Chung, J et al. (2000) Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol. Microbiol. 35 1099-109 PubMed
  10. ↑ Stewart, EJ et al. (1999) Six conserved cysteines of the membrane protein DsbD are required for the transfer of electrons from the cytoplasm to the periplasm of Escherichia coli. EMBO J. 18 5963-71 PubMed

Categories

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