dipZ:Quickview
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| References | Suggestions |
<protect>
| Standard Name |
dsbD |
|---|---|
| Gene Synonym(s) |
dipZ, ECK4130, b4136, JW5734, cutA2, cycZ, htrI, dsbD[1][2], htrI |
| Product Desc. |
fused thiol:disulfide interchange protein[3]: membrane electron transporter[4]: activator of DsbC[1] |
| Product Synonyms(s) |
B4136[2][1], HtrI[2][1], CycZ[2][1], DipZ, cutA2, cycZ, dipZ, ECK4130, htrI, JW5734, b4136 |
| Function from GO |
<GO_nr /> |
| Knock-Out Phenotype |
copper sensitivity PMID:8917542[4] PMID:16087673[5]: temperature sensitivity PMID:7628442[3] |
| Regulation/Expression | |
| Regulation/Activity |
The bacterial membrane protein DsbD transfers electrons across the cytoplasmic membrane to reduce protein disulfide bonds in extracytoplasmic proteins. Its substrates include protein disulfide isomerases and a protein involved in cytochrome c assembly. It has three domains, each containing two redox-active cysteines. Electrons are transferred between them through thiol-disulfide exchange reactions. |
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Notes
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 Missiakas, D et al. (1995) Identification and characterization of a new disulfide isomerase-like protein (DsbD) in Escherichia coli. EMBO J. 14 3415-24 PubMed
- ↑ 4.0 4.1 Rietsch, A et al. (1996) An in vivo pathway for disulfide bond isomerization in Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 93 13048-53 PubMed
- ↑ Hiniker, A et al. (2005) Copper stress causes an in vivo requirement for the Escherichia coli disulfide isomerase DsbC. J. Biol. Chem. 280 33785-91 PubMed
