parC:Gene Product(s): Difference between revisions
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DNA topoisomerase (ATP-hydrolyzing) activity | DNA topoisomerase (ATP-hydrolyzing) activity | ||
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[[PMID: | [[PMID:8227000]]<ref name=PMID:8227000/> | ||
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IDA: Inferred from Direct Assay | IDA: Inferred from Direct Assay | ||
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F | F | ||
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complete | |||
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[[Category:GO:0009330_!_DNA_topoisomerase_complex_(ATP-hydrolyzing)]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0009330_!_DNA_topoisomerase_complex_(ATP-hydrolyzing) GO:0009330] | |||
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DNA topoisomerase complex (ATP-hydrolyzing) | |||
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[[PMID:8227000]]<ref name=PMID:8227000/> | |||
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IDA: Inferred from Direct Assay | |||
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C | |||
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Revision as of 20:39, 4 December 2008
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| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
| Standard name |
ParC |
|---|---|
| Synonyms | |
| Product description |
topoisomerase IV subunit A[2][3]; Component of dimer of topoisomerase IV subunit A[3]; topoisomerase IV[3] |
| EC number (for enzymes) | |
| edit table |
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference(s) | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0003677 |
DNA binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0003916 |
DNA topoisomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0005524 |
ATP binding |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0005694 |
chromosome |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
C |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0006265 |
DNA topological change |
GO_REF:0000002 |
IEA: Inferred from Electronic Annotation |
InterPro:IPR002205 |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |
| GO:0006268 |
DNA unwinding during replication |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0016020 |
membrane |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0016853 |
isomerase activity |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc 12.5 [4] |
complete | |||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
Seeded from EcoCyc 11.1[3]. |
complete | |||
| GO:0006261 |
DNA-dependent DNA replication |
IDA: Inferred from Direct Assay |
P |
Seeded from EcoCyc 11.1[3]. |
complete | |||
| GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
F |
required field missing | ||||
| GO:0007059 |
chromosome segregation |
IMP: Inferred from Mutant Phenotype |
P |
complete | ||||
|
Contributes to |
GO:0003916 |
DNA topoisomerase activity |
IDA: Inferred from Direct Assay |
EcoliWiki: parE |
F |
complete | ||
| GO:0019897 |
extrinsic to plasma membrane |
IDA: Inferred from Direct Assay |
C |
in the presence of DNA |
complete | |||
| GO:0005737 |
cytoplasm |
IDA: Inferred from Direct Assay |
C |
in the presence of Mg2+ |
complete | |||
|
Contributes to |
GO:0003918 |
DNA topoisomerase (ATP-hydrolyzing) activity |
IDA: Inferred from Direct Assay |
EcoliWiki: parE |
F |
complete | ||
| GO:0009330 |
DNA topoisomerase complex (ATP-hydrolyzing) |
IDA: Inferred from Direct Assay |
C |
complete | ||||
| edit table |
Interactions
| Partner Type | Partner | Notes | References |
|---|---|---|---|
|
Protein |
Subunits of dimer of topoisomerase IV subunit A |
could be indirect |
|
|
Protein |
Subunits of topoisomerase IV |
could be indirect |
|
| edit table |
See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
Notes
Localization
| Compartment | Description | Evidence | Notes |
|---|---|---|---|
|
cytoplasm |
From EcoCyc[3] | ||
| edit table |
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
Notes
Structure and Physical Properties
Physical Properties
| Sequence |
MSDMAERLAL HEFTENAYLN YSMYVIMDRA LPFIGDGLKP VQRRIVYAMS ELGLNASAKF KKSARTVGDV LGKYHPHGDS ACYEAMVLMA QPFSYRYPLV DGQGNWGAPD DPKSFAAMRY TESRLSKYSE LLLSELGQGT ADWVPNFDGT LQEPKMLPAR LPNILLNGTT GIAVGMATDI PPHNLREVAQ AAIALIDQPK TTLDQLLDIV QGPDYPTEAE IITSRAEIRK IYENGRGSVR MRAVWKKEDG AVVISALPHQ VSGARVLEQI AAQMRNKKLP MVDDLRDESD HENPTRLVIV PRSNRVDMDQ VMNHLFATTD LEKSYRINLN MIGLDGRPAV KNLLEILSEW LVFRRDTVRR RLNYRLEKVL KRLHILEGLL VAFLNIDEVI EIIRNEDEPK PALMSRFGLT ETQAEAILEL KLRHLAKLEE MKIRGEQSEL EKERDQLQGI LASERKMNNL LKKELQADAQ AYGDDRRSPL QEREEAKAMS EHDMLPSEPV TIVLSQMGWV RSAKGHDIDA PGLNYKAGDS FKAAVKGKSN QPVVFVDSTG RSYAIDPITL PSARGQGEPL TGKLTLPPGA TVDHMLMESD DQKLLMASDA GYGFVCTFND LVARNRAGKA LITLPENAHV MPPVVIEDAS DMLLAITQAG RMLMFPVSDL PQLSKGKGNK IINIPSAEAA RGEDGLAQLY VLPPQSTLTI HVGKRKIKLR PEELQKVTGE RGRRGTLMRG LQRIDRVEID SPRRASSGDS EE |
|---|---|
| Mol. Wt |
83.83 kDa (calc) [2] |
| pI | |
| Extinction coefficient |
55810 - 56060 (calc based on 19 Y, 5 W, and 2 C residues) |
| edit table |
See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
Domains/Motifs/Modification Sites
| Type | Residues | Description | Notes |
|---|---|---|---|
| edit table |
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
Structure
| Structures |
<beststructure>parC 562</beststructure> |
|---|---|
| Models |
View models at: |
| edit table |
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.
Notes
Gene Product Resources
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
Notes
Accessions in Other Databases
| Database | Accession | Notes |
|---|---|---|
|
| ||
| edit table |
See Help:Product_accessions for help entering or editing information in this section of EcoliWiki.
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
See Help:Links_table for how to enter or edit information in this section of EcoliWiki.
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 EcoCyc (release 12.5; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ Espeli, O et al. (2003) Temporal regulation of topoisomerase IV activity in E. coli. Mol. Cell 11 189-201 PubMed
- ↑ Kato, J et al. (1990) New topoisomerase essential for chromosome segregation in E. coli. Cell 63 393-404 PubMed
- ↑ Kato, J et al. (1988) Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. J. Bacteriol. 170 3967-77 PubMed
- ↑ 8.0 8.1 8.2 Kato, J et al. (1992) Purification and characterization of DNA topoisomerase IV in Escherichia coli. J. Biol. Chem. 267 25676-84 PubMed
- ↑ 9.0 9.1 Peng, H & Marians, KJ (1993) Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J. Biol. Chem. 268 24481-90 PubMed
Categories
- GO:0003677 ! DNA binding
- GO:0003916 ! DNA topoisomerase activity
- GO:0003918 ! DNA topoisomerase (ATP-hydrolyzing) activity
- GO:0005524 ! ATP binding
- GO:0005694 ! chromosome
- GO:0006265 ! DNA topological change
- GO:0006268 ! DNA unwinding during replication
- GO:0016020 ! membrane
- GO:0016853 ! isomerase activity
- GO:0005737 ! cytoplasm
- GO:0006261 ! DNA-dependent DNA replication
- GO:0007059 ! chromosome segregation
- GO:0019897 ! extrinsic to plasma membrane
- GO:0009330 ! DNA topoisomerase complex (ATP-hydrolyzing)
- Proteins
- Complex:dimer of topoisomerase IV subunit A
- Complex:topoisomerase IV
- Location:cytoplasm
- Products with structures in PDB
- GO Annotation by EcoliWiki Team