envZ:Gene Product(s): Difference between revisions
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!align=left {{table heading style}} |Synonyms | !align=left {{table heading style}} |Synonyms | ||
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sensory histidine kinase in two-component regulatory system with OmpR<ref name='LIB:Riley_2006'/>, B3404<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Tpo<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Kmt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OmpB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PerA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, unphosphorylated osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, unmodified osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> | ''sensory histidine kinase in two-component regulatory system with OmpR<ref name='LIB:Riley_2006'/>, B3404<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Tpo<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Kmt<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, OmpB<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, PerA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, unphosphorylated osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, unmodified osmolarity sensor kinase-phosphotransferase EnvZ<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , cpr, ECK3391, JW3367, ompB, perA, tpo, b3404'' | ||
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!align=left {{table heading style}} |Product description | !align=left {{table heading style}} |Product description | ||
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** PLEASE DON'T EDIT THIS TABLE DIRECTLY. Use the edit table link under the table. ** | |||
* | * | ||
****************************************************************************************** -->{{Product_GO_help}} | ****************************************************************************************** -->{{Product_GO_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="H46aae72b6b897" class=" tableEdit GO_table_product dataTable" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Qualifier!!GO ID!!GO term name!!Reference | !|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status | ||
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Seeded from [[EcoCyc]] (v14.0) | Seeded from [[EcoCyc]] (v14.0) | ||
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Seeded from [[EcoCyc]] (v14.0) | Seeded from [[EcoCyc]] (v14.0) | ||
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|- class="tableEdit_footer" | |- class="tableEdit_footer" | ||
|< | |<div class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27298.H46aae72b6b897&page=27298&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</div> || || || || || || || || | ||
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****************************************************************************************** -->{{Product_interactions_help}} | ****************************************************************************************** -->{{Product_interactions_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="O46aae731f0f6b" class=" tableEdit Product_interactions_table dataTable" | ||
|- {{table heading style}} | |- {{table heading style}} | ||
!|Partner Type!!Partner!!Notes!!References!!Evidence | !|Partner Type!!Partner!!Notes!!References!!Evidence | ||
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Protein | Protein | ||
| | | | ||
Subunits of | Subunits of EnvZ | ||
| | | | ||
could be indirect | could be indirect | ||
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* | * | ||
****************************************************************************************** -->{{Product_localization_help}} | ****************************************************************************************** -->{{Product_localization_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="I46aae7334ab09" class=" tableEdit Product_localization_table" | ||
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!|Compartment!!Description!!Evidence!!Source!!Notes | !|Compartment!!Description!!Evidence!!Reference/Source!!Notes | ||
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{| id="D46aae7354d737" class=" tableEdit Product_phys_prop_table" | {| id="D46aae7354d737" class=" tableEdit Product_phys_prop_table" | ||
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!align=left {{table heading style}} |Name | |||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="R46aae735c337b" class=" tableEdit Product_motif_table dataTable" | ||
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!|Type!!Residues!!Description!!Notes!!References | !|Type!!Residues!!Description!!Notes!!References | ||
|- | |||
| | |||
Domain | |||
| | |||
160..229 | |||
| | |||
[http://pfam.janelia.org/family/PF00672 PF00672 HAMP domain] | |||
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PMID:19920124 | |||
|- | |||
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Domain | |||
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332..439 | |||
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[http://pfam.janelia.org/family/PF02518 PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase] | |||
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PMID:19920124 | |||
|- | |||
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Domain | |||
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233..293 | |||
| | |||
[http://pfam.janelia.org/family/PF00512 PF00512 His Kinase A (phosphoacceptor) domain] | |||
| | |||
| | |||
PMID:19920124 | |||
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View models at: | View models at: | ||
* [http:// | * [http://www.proteinmodelportal.org/query/uniprot/P0AEJ4 Protein Model Portal] | ||
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P0AEJ4 PSI-PRED (P0AEJ4)] | |||
* [http://bioinf.cs.ucl.ac.uk/ | * [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P0AEJ4 Genomes TO Protein (P0AEJ4)] (GTOP) | ||
* [http://spock.genes.nig.ac.jp/~genome/ | |||
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****************************************************************************************** -->{{Product_resources_help}} | ****************************************************************************************** -->{{Product_resources_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="M46aae73698f0a" class=" tableEdit Product_resource_table" | ||
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!|Resource type!!Source!!Notes/Reference | !|Resource type!!Source!!Notes/Reference | ||
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****************************************************************************************** -->{{Gene_accessions_help}} | ****************************************************************************************** -->{{Gene_accessions_help}} | ||
{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="S46aae73709088" class=" tableEdit Gene_accessions_table" | ||
|- {{table_heading_style}} | |- {{table_heading_style}} | ||
!|Database!!Accession!!Notes | !|Database!!Accession!!Notes | ||
|- | |- | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | ||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/16131281 GI:16131281] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]]) | |||
| | |||
[http://www.ncbi.nlm.nih.gov/protein/NP_417863.1 GeneID:947272] | |||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | | | ||
[[ASAP]] | |||
| | |||
ASAP:ABE-0011108 | |||
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''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |||
| | |||
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]]) | |||
| | |||
[http://www.uniprot.org/uniprot/P0AEJ4 UniProtKB/Swiss-Prot:P0AEJ4] | |||
| | |||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |||
| | |||
[[EcoCyc]] | |||
| | |||
EcoCyc:EG10269 | |||
| | |||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[[EcoGene]] | |||
| | | | ||
EcoGene:EG10269 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
| | | | ||
[http:// | [http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]]) | ||
| | | | ||
[ | [http://www.ncbi.nlm.nih.gov/gene?term=947272 GeneID:947272] | ||
| | | | ||
Escherichia coli str. K-12 substr. MG1655 | |||
|- | |- | ||
| | | | ||
[[RegulonDB]] | |||
| | | | ||
RegulonDB:ECK120000263 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
|- | |- | ||
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[[EchoBASE]] | |||
| | | | ||
EchoBASE:EB0265 | |||
| | | | ||
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]] | |||
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{| | {| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;" id="P46a877601886e" class=" tableEdit Links_table" | ||
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[[Category:Proteins]] | [[Category:Proteins]] | ||
Latest revision as of 04:01, 19 May 2019
{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>
| Quickview | Gene | Gene Product(s) | Expression | Evolution | On One Page |
| Nomenclature | Function | Interactions | Localization | Sequence | Domains | Structure | Resources | Accessions | Links | References | Suggestions |
Nomenclature
See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.
| Standard name |
EnvZ |
|---|---|
| Synonyms |
sensory histidine kinase in two-component regulatory system with OmpR[1], B3404[2][1], Tpo[2][1], Kmt[2][1], OmpB[2][1], PerA[2][1], EnvZ[2][1], osmolarity sensor kinase-phosphotransferase EnvZ[2][1], unphosphorylated osmolarity sensor kinase-phosphotransferase EnvZ[2][1], unmodified osmolarity sensor kinase-phosphotransferase EnvZ[2][1] , cpr, ECK3391, JW3367, ompB, perA, tpo, b3404 |
| Product description |
Osmosensor histidine protein kinase/phosphatase; regulates production of outer membrane proteins; dimeric[4] |
| EC number (for enzymes) |
|
| edit table |
Notes
Function
Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.
| Qualifier | GO ID | GO term name | Reference | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0016310 |
phosphorylation |
IDA: Inferred from Direct Assay |
P |
Figure 1 |
complete | |||
| GO:0000155 |
two-component sensor activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000155 |
two-component sensor activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000160 |
two-component signal transduction system (phosphorelay) |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000166 |
nucleotide binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004673 |
protein histidine kinase activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004673 |
protein histidine kinase activity |
GOA:spec |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004871 |
signal transducer activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0004871 |
signal transducer activity |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005524 |
ATP binding |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0005886 |
plasma membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0007165 |
signal transduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0007165 |
signal transduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0046777 |
protein amino acid autophosphorylation |
IDA: Inferred from Direct Assay |
P |
Figure 1 |
complete | |||
| GO:0007165 |
signal transduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0007165 |
signal transduction |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016020 |
membrane |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0000160 |
two-component signal transduction system (phosphorelay) |
IDA: Inferred from Direct Assay |
P |
with NRI- Figure 2 |
complete | |||
| GO:0016020 |
membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0006470 |
protein amino acid dephosphorylation |
IDA: Inferred from Direct Assay |
P |
dephosphorylates OmpR- Figure 7 |
complete | |||
| GO:0016021 |
integral to membrane |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016021 |
integral to membrane |
IEA: Inferred from Electronic Annotation |
SP_SL:SL-9909 |
C |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016301 |
kinase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016310 |
phosphorylation |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016740 |
transferase activity |
GOA:spkw |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
F |
Seeded from EcoCyc (v14.0) |
complete | ||
| GO:0018106 |
peptidyl-histidine phosphorylation |
GOA:interpro |
IEA: Inferred from Electronic Annotation |
P |
Seeded from EcoCyc (v14.0) |
complete | ||
Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.
| Partner Type | Partner | Notes | References | Evidence |
|---|---|---|---|---|
|
Protein |
Subunits of EnvZ |
could be indirect |
| |
| edit table |
Notes
Localization
See Help:Product_localization for how to add or edit information in this section of EcoliWiki.
| Compartment | Description | Evidence | Reference/Source | Notes |
|---|---|---|---|---|
|
plasma membrane |
C-terminus localized in the cytoplasm with 2 predicted transmembrane domains |
Daley et al. (2005) [6] |
||
|
plasma membrane |
From EcoCyc[3] |
| ||
| edit table |
Notes
Structure and Physical Properties
Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.
| Name | |
|---|---|
| Sequence |
MRRLRFSPRS SFARTLLLIV TLLFASLVTT YLVVLNFAIL PSLQQFNKVL AYEVRMLMTD KLQLEDGTQL VVPPAFRREI YRELGISLYS NEAAEEAGLR WAQHYEFLSH QMAQQLGGPT EVRVEVNKSS PVVWLKTWLS PNIWVRVPLT EIHQGDFSPL FRYTLAIMLL AIGGAWLFIR IQNRPLVDLE HAALQVGKGI IPPPLREYGA SEVRSVTRAF NHMAAGVKQL ADDRTLLMAG VSHDLRTPLT RIRLATEMMS EQDGYLAESI NKDIEECNAI IEQFIDYLRT GQEMPMEMAD LNAVLGEVIA AESGYEREIE TALYPGSIEV KMHPLSIKRA VANMVVNAAR YGNGWIKVSS GTEPNRAWFQ VEDDGPGIAP EQRKHLFQPF VRGDSARTIS GTGLGLAIVQ RIVDNHNGML ELGTSERGGL SIRAWLPVPV TRAQGTTKEG |
| Length |
450 |
| Mol. Wt |
50.334 kDa |
| pI |
6.8 (calculated) |
| Extinction coefficient |
61,880 - 62,005 (calc based on 12 Y, 8 W, and 1 C residues) |
| edit table |
Domains/Motifs/Modification Sites
|
See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.
|
<motif_map/> |
|
Structure
|
Structure figures
Notes
Gene Product Resources
See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.
| Resource type | Source | Notes/Reference |
|---|---|---|
| edit table |
Notes
Accessions in Other Databases
See Help:Gene_accessions for help with entering information into the Gene Accessions table.
| Database | Accession | Notes |
|---|---|---|
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
|
Escherichia coli str. K-12 substr. MG1655 | ||
| edit table |
Notes
Links
| Name | URL | Comments |
|---|---|---|
| edit table |
References
See Help:References for how to manage references in EcoliWiki.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ 3.0 3.1 3.2 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
- ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
- ↑ 5.0 5.1 5.2 5.3 Igo, MM et al. (1989) Phosphorylation and dephosphorylation of a bacterial transcriptional activator by a transmembrane receptor. Genes Dev. 3 1725-34 PubMed
- ↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed
- ↑ 7.0 7.1 7.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed
Categories
- GO:0016310 ! phosphorylation
- GO:0000155 ! phosphorelay sensor kinase activity
- GO:0000160 ! phosphorelay signal transduction system
- GO:0000166 ! nucleotide binding
- GO:0004673 ! protein histidine kinase activity
- GO:0004871 ! obsolete signal transducer activity
- GO:0005524 ! ATP binding
- GO:0005886 ! plasma membrane
- GO:0007165 ! signal transduction
- GO:0046777 ! protein autophosphorylation
- GO:0016020 ! membrane
- GO:0006470 ! protein dephosphorylation
- GO:0016021 ! integral component of membrane
- GO:0016301 ! kinase activity
- GO:0016740 ! transferase activity
- GO:0016772 ! transferase activity, transferring phosphorus-containing groups
- GO:0018106 ! peptidyl-histidine phosphorylation
- TMHMM Prediction
- Proteins
