dnaA:Gene Product(s): Difference between revisions

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|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Localization |Localization]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Sequence|Sequence]]
|{{Sub}}[[#Domains/Motifs/Modification Sites|Domains]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Structure|Structure]]
|{{Sub}}[[#Gene Product Resources|Resources]]
|{{Sub}}[[#Gene Product Resources|Resources]]
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{|  id="T46aafcc991b86"  class=" tableEdit Product_nomenclature_table" 
 
|-
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!{{table heading style}} |Standard name
!align=left {{table heading style}} |Standard name
|
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DnaA product
DnaA  
|-
|-
!{{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
|
||
chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator product<ref name='LIB:Riley_2006'/>, B3702 product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaA product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator product<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator<ref name='LIB:Riley_2006'/>, B3702<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DnaA<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3694, JW3679, b3702''
|-
|-
!{{table heading style}} |Product description
!align=left {{table heading style}} |Product description
|
||
DnaA transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>
DnaA transcriptional dual regulator<ref name='LIB:EcoCyc10.6'/><ref name='LIB:EcoCyc11.1'/>


DNA synthesis initiator and global transcription regulator; binds DNA at DnaA boxes, binds cardiolipin and other acidic phospholipids, binds ATP<ref name='LIB:EcoGene'/>
|-
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!{{table heading style}} |EC number (for enzymes)
!align=left {{table heading style}} |EC number (for enzymes)
|
||
*
 
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{{Product_nomenclature_help}}
 
<protect><!--Nomenclature_notes--></protect>
<protect><!--Nomenclature_notes--></protect>
===Notes===
===Notes===
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{{BacktoTop}}
<protect>
<protect>
<big>'''Gene Ontology'''</big>
<big>'''Gene Ontology'''</big><br /><!--box uid=421aa90e079fa326b6494f812ad13e79.27983.W46aafccab4f9c-->
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{|class = 'sortable' border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"   
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="W46aafccab4f9c"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0006275
|
regulation of DNA replication
|
PMID:12068813
|
IMP: Inferred from Mutant Phenotype
|
 
|
P
|
 
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006275_!_regulation_of_DNA_replication]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006275_!_regulation_of_DNA_replication GO:0006275]
GO:0006260
|
|
regulation_of_DNA_replication
DNA replication
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
PMID:12068813
|
|
IEA: Inferred from Electronic Annotation
IMP: Inferred from Mutant Phenotype
|
|
InterPro:IPR013159
 
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0017111_!_nucleoside-triphosphatase_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0017111_!_nucleoside-triphosphatase_activity GO:0017111]
GO:0000166
|
|
nucleoside-triphosphatase_activity
nucleotide binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 110: Line 132:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0005524_!_ATP_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005524_!_ATP_binding GO:0005524]
GO:0000166
|
|
ATP_binding
nucleotide binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR001957
SP_KW:KW-0547
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0005524_!_ATP_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005524_!_ATP_binding GO:0005524]
GO:0003677
|
|
ATP_binding
DNA binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR013159
InterPro:IPR001957
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0005524_!_ATP_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005524_!_ATP_binding GO:0005524]
GO:0003677
|
|
ATP_binding
DNA binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0067
InterPro:IPR018312
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006260_!_DNA_replication]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006260_!_DNA_replication GO:0006260]
GO:0003677
|
|
DNA_replication
DNA binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0235
SP_KW:KW-0238
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006270_!_DNA_replication_initiation]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006270_!_DNA_replication_initiation GO:0006270]
GO:0003688
|
|
DNA_replication_initiation
DNA replication origin binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000020 GO_REF:0000020]<br />
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 203: Line 225:
HAMAP:MF_00377
HAMAP:MF_00377
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006270_!_DNA_replication_initiation]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006270_!_DNA_replication_initiation GO:0006270]
GO:0003688
|
|
DNA_replication_initiation
DNA replication origin binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 222: Line 244:
InterPro:IPR001957
InterPro:IPR001957
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006270_!_DNA_replication_initiation]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006270_!_DNA_replication_initiation GO:0006270]
GO:0003688
|
|
DNA_replication_initiation
DNA replication origin binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR013159
InterPro:IPR018312
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006275_!_regulation_of_DNA_replication]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006275_!_regulation_of_DNA_replication GO:0006275]
GO:0005524
|
|
regulation_of_DNA_replication
ATP binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000020 GO_REF:0000020]<br />
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 260: Line 282:
HAMAP:MF_00377
HAMAP:MF_00377
|
|
P
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006275_!_regulation_of_DNA_replication]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006275_!_regulation_of_DNA_replication GO:0006275]
GO:0005524
|
|
regulation_of_DNA_replication
ATP binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 279: Line 301:
InterPro:IPR001957
InterPro:IPR001957
|
|
P
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0005524
|
ATP binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR013159
|
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0003688_!_DNA_replication_origin_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003688_!_DNA_replication_origin_binding GO:0003688]
GO:0005524
|
|
DNA_replication_origin_binding
ATP binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000020 GO_REF:0000020]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
HAMAP:MF_00377
InterPro:IPR018312
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0043565
|
sequence-specific DNA binding
|
PMID:10551881
|
IDA: Inferred from Direct Assay
|
 
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0003688_!_DNA_replication_origin_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003688_!_DNA_replication_origin_binding GO:0003688]
GO:0005524
|
|
DNA_replication_origin_binding
ATP binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR001957
SP_KW:KW-0067
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0005524_!_ATP_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005524_!_ATP_binding GO:0005524]
GO:0005737
|
|
ATP_binding
cytoplasm
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000020 GO_REF:0000020]<br />
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 336: Line 396:
HAMAP:MF_00377
HAMAP:MF_00377
|
|
F
C
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0005737
|
cytoplasm
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0963
|
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0000166_!_nucleotide_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0000166_!_nucleotide_binding GO:0000166]
GO:0005737
|
|
nucleotide_binding
cytoplasm
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GO_REF:0000023
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR003593
SP_SL:SL-0086
|
|
F
C
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0000166_!_nucleotide_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0000166_!_nucleotide_binding GO:0000166]
GO:0006270
|
|
nucleotide_binding
DNA-dependent DNA replication initiation
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0547
HAMAP:MF_00377
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0003677_!_DNA_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003677_!_DNA_binding GO:0003677]
GO:0006270
|
|
DNA_binding
DNA-dependent DNA replication initiation
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 393: Line 472:
InterPro:IPR001957
InterPro:IPR001957
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0003677_!_DNA_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0003677_!_DNA_binding GO:0003677]
GO:0006270
|
|
DNA_binding
DNA-dependent DNA replication initiation
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0238
InterPro:IPR013159
|
|
F
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|


|
|
[[Category:GO:0006261_!_DNA-dependent_DNA_replication]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006261_!_DNA-dependent_DNA_replication GO:0006261]
GO:0006270
|
|
DNA-dependent DNA replication
DNA-dependent DNA replication initiation
|
|
[[PMID:2839499]]<ref name=PMID:2839499/>
GOA:interpro<br />GO_REF:0000002
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
InterPro:IPR018312
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
|


|
GO:0006275
|
regulation of DNA replication
|
GOA:hamap<br />GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00377
|
|
P
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 440: Line 538:


|
|
[[Category:GO:0005737_!_cytoplasm]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0005737_!_cytoplasm GO:0005737]
GO:0006275
|
|
cytoplasm
regulation of DNA replication
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000004 GO_REF:0000004]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0963
InterPro:IPR001957
|
|
C
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0006350_!_transcription]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0006350_!_transcription GO:0006350]
GO:0006275
|
|
transcription
regulation of DNA replication
|
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR013159
|
|
P  
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0016564_!_transcription_repressor_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016564_!_transcription_repressor_activity GO:0016564]
GO:0006275
|
|
transcription repressor activity
regulation of DNA replication
|
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR018312
|
|
F
P
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|
 
|
|
[[Category:GO:0016563_!_transcription_activator_activity]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0016563_!_transcription_activator_activity GO:0016563]
GO:0017111
|
|
transcription activator activity  
nucleoside-triphosphatase activity
|
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR003593
|
|
F  
F
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
[[Category:GO:0043565_!_sequence-specific_DNA_binding]][http://gowiki.tamu.edu/wiki/index.php/Category:GO:0043565_!_sequence-specific_DNA_binding GO:0043565]
GO:0043565
|
|
sequence-specific_DNA_binding
sequence-specific DNA binding
|
|
[http://www.geneontology.org/cgi-bin/references.cgi/#GO_REF:0000002 GO_REF:0000002]<br />
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 528: Line 626:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0043565
|
sequence-specific DNA binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR013159
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete


|-class='sortbottom'
|- class="tableEdit_footer"
|[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.W46aafccab4f9c&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table] || || || || || || || ||
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.W46aafccab4f9c&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=GO_table_product edit table]</span> || || || || || || || ||
|}
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{{Product_GO_help}}


<span id="Interactions"></span><big>'''Interactions'''</big>
<span id="Interactions"></span><big>'''Interactions'''</big>
Line 542: Line 658:
<!--
<!--
******************************************************************************************
******************************************************************************************
*
*  
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **
*  ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. **  
*
*  
****************************************************************************************** -->
****************************************************************************************** -->{{Product_interactions_help}}
{|class = 'sortable' {{Prettytable}} id='178550'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="R46aafcdab0fb5"  class=" tableEdit Product_interactions_table dataTable" 
|- {{table heading style}}
|- {{table heading style}}
!Partner Type!!Partner!!Notes
!|Partner Type!!Partner!!Notes!!References!!Evidence
|-class='sortbottom'
|-
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.R46aafcdab0fb5&page=27983&pagename={{FULLPAGENAMEE}} edit table] || ||
|
Protein
|
aspS<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
cca<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
dnaJ<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418, EBI-890702<br />
|-
|
Protein
|
lpdA<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
nadE<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
rplB<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418, EBI-890702<br />
|-
|
Protein
|
rplD<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
rpsB<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418, EBI-890702<br />
|-
|
Protein
|
tufA<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-883418<br />
|-
|
Protein
|
rpsI<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
yfdS<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
yibL<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
rpsG<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
groL<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
dgt<br />
|
 
|
PMID:16606699
|
Experiment(s):EBI-1146527<br />
|-
|
Protein
|
creC<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplC<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplL<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplN<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplO<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplP<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplV<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplW<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplX<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpmB<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsC<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsE<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsG<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsI<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsJ<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsM<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsN<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rpsT<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
ynhG<br />
|
 
|
PMID:15690043
|
Experiment(s):EBI-890702<br />
|-
|
Protein
|
rplP
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.5
|-
|
Protein
|
rpsT
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rplO
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rplN
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rpsN
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rpsD
|
 
|
PMID:19402753
|
LCMS(ID Probability):95.6 MALDI(Z-score):19.412920
|-
|
Protein
|
rpsM
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
nadE
|
 
|
PMID:19402753
|
MALDI(Z-score):23.368207
|-
|
Protein
|
rpsJ
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rplB
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6 MALDI(Z-score):17.312848
|-
|
Protein
|
tufB
|
 
|
PMID:19402753
|
MALDI(Z-score):22.493646
|-
|
Protein
|
rplX
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
rpsC
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6 MALDI(Z-score):6.532571
|-
|
Protein
|
ynhG
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
creC
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.0
|-
|
Protein
|
dnaJ
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6 MALDI(Z-score):17.405523
|-
|
Protein
|
rplD
|
 
|
PMID:19402753
|
LCMS(ID Probability):96.5 MALDI(Z-score):23.806084
|-
|
Protein
|
rplL
|
 
|
PMID:19402753
|
LCMS(ID Probability):99.6
|-
|
Protein
|
Dps
|
 
|
PMID:18284581
|
Affinity chromatography and solid phase binding assay
|-
|
Protein
|
Hda
|
 
|
PMID:11483528
|
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.R46aafcdab0fb5&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=Product_interactions_table edit table]</span> || || || ||
|}
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{{Product_interactions_help}}
 
<!--Function_notes--></protect>
<!--Function_notes--></protect>
===Notes===
===Notes===
Line 562: Line 1,273:
<!--
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*
*  
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****************************************************************************************** -->{{Product_localization_help}}
{|class = 'sortable' {{Prettytable}} id='119216'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="N46a888b77216a"  class=" tableEdit Product_localization_table" 
|- {{table heading style}}
|- {{table heading style}}
!Compartment!!Description!!Evidence!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes
|-class='sortbottom'
 
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.N46a888b77216a&page=27983&pagename={{FULLPAGENAMEE}} edit table] || || ||
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|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.N46a888b77216a&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=Product_localization_table edit table]</span> || || || ||
|}
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{{Product_localization_help}}
 
<protect><!--Localization_notes--></protect>
<protect><!--Localization_notes--></protect>


Line 586: Line 1,298:
<!--
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*
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****************************************************************************************** -->{{Product_physical_properties_help}}
{|{{Prettytable}}
{|   id="Y46aafcdcdc9ab"  class=" tableEdit Product_phys_prop_table" 
 
|-
!align=left {{table heading style}} |Name
||
 
|-
|-
!{{table heading style}} |Sequence
!align=left {{table heading style}} |Sequence
|
||
[http://biocyc.org/ECOLI/sequence-aa?object=PD03831 at EcoCyc]  
[http://biocyc.org/ECOLI/sequence-aa?object=PD03831 at EcoCyc]  
<pre>MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
<pre>MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
Line 604: Line 1,321:
SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN LIRTLSS</pre>  
SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN LIRTLSS</pre>  
|-
|-
!{{table heading style}} |Mol. Wt
!align=left {{table heading style}} |Length
|
||
52.55 kDa (calc) <ref name='LIB:EcoCyc10.6'/>
467
|-
|-
!{{table heading style}} |pI
!align=left {{table heading style}} |Mol. Wt
|
||
8.67<ref name='LIB:EcoCyc10.6'/>
52.551 kDa
|-
|-
!{{table heading style}} |Extinction coefficient
!align=left {{table heading style}} |pI
|
||
43890 - 44265 (calc based on 11 Y, 5 W, and 3 C residues)  
8.9 (calculated)
|-
|-
|colspan='2'|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.Y46aafcdcdc9ab&page=27983&pagename={{FULLPAGENAMEE}} edit table]
!align=left {{table heading style}} |Extinction coefficient
||
43,890 - 44,265 (calc based on 11 Y, 5 W, and 3 C residues)
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.Y46aafcdcdc9ab&page=27983&pagename={{FULLPAGENAMEE}}&type=1&template=Product_phys_prop_table edit table]</span> ||
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{{Product_physical_properties_help}}


<big>'''Domains/Motifs/Modification Sites'''</big>
 
<!--box uid=421aa90e079fa326b6494f812ad13e79.27983.I46aafcdd62c15-->
<span id="Domains/Motifs/Modification Sites"><big>'''Domains/Motifs/Modification Sites'''</big></span><table>
<tr align="left" valign="top">
<td><!--box uid=421aa90e079fa326b6494f812ad13e79.27983.I46aafcdd62c15-->
<!--
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*
*  
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****************************************************************************************** -->{{Product_domains_motifs_help}}
{|class = 'sortable' {{Prettytable}} id='178552'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="I46aafcdd62c15"  class=" tableEdit Product_motif_table dataTable" 
|- {{table heading style}}
|- {{table heading style}}
!Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-class='sortbottom'
|-
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.I46aafcdd62c15&page=27983&pagename={{FULLPAGENAMEE}} edit table] || || ||
|
Domain
|
132..350
|
[http://pfam.janelia.org/family/PF00308 PF00308  Bacterial dnaA  protein]
|
 
|
PMID:19920124
|-
|
Domain
|
375..444
|
[http://pfam.janelia.org/family/PF08299 PF08299  domain]
|
 
|
PMID:19920124
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.I46aafcdd62c15&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=Product_motif_table edit table]</span> || || || ||
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<!--box uid=421aa90e079fa326b6494f812ad13e79.27983.I46aafcdd62c15--></td>
{{Product_domains_motifs_help}}
<td>
<!-- motifs column 2-->
<motif_map/>
</td>
</tr>
</table>


<span id="Structure"></span><big>'''Structure'''</big>
<table><tr valign='top'><td>
<span id='Structure'></span><big>'''Structure'''</big><br />
<!--box uid=421aa90e079fa326b6494f812ad13e79.27983.E46a888b91618b-->
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<!--
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*
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****************************************************************************************** -->{{Product_structure_help}}
{|class = 'sortable' {{Prettytable}} id='119217'
{|   id="E46a888b91618b"  class=" tableEdit Product_structure_table" 
|- {{table heading style}}
 
!Structure Type!!Organism!!Accession!!Residues covered!!Notes
|-
|-class='sortbottom'
!align=left {{table heading style}} |Structures
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.E46a888b91618b&page=27983&pagename={{FULLPAGENAMEE}} edit table] || || || ||
||
<beststructure>
gene=dnaA
taxon=562,83333
</beststructure>
|-
!align=left {{table heading style}} |Models
||
View models at:
* [http://www.proteinmodelportal.org/query/uniprot/P03004 Protein Model Portal]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P03004 PSI-PRED (P03004)]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P03004 Genomes TO Protein (P03004)] (GTOP)
 
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.E46a888b91618b&page=27983&pagename={{FULLPAGENAMEE}}&type=1&template=Product_structure_table edit table]</span> ||
|}
|}
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{{Product_structure_help}}
 
<!--Structure_notes--></protect>
</td><td></protect>
==== Structure figures ====
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
<protect><!--          ***** PLEASE DO NOT EDIT BELOW THIS LINE *****        -->
</td><tr><table><!--Structure_notes--></protect>
===Notes===
===Notes===


Line 663: Line 1,451:
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*
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{|class = 'sortable' {{Prettytable}} id='178553'
{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="E46aafcde39678"  class=" tableEdit Product_resource_table" 
|- {{table_heading_style}}
|- {{table_heading_style}}
!Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference
|-class='sortbottom'
 
|[{{SERVER}}{{SCRIPTPATH}}/index.php?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.E46aafcde39678&page=27983&pagename={{FULLPAGENAMEE}} edit table] || ||
|- class="tableEdit_footer"
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=421aa90e079fa326b6494f812ad13e79.27983.E46aafcde39678&page=27983&pagename={{FULLPAGENAMEE}}&type=&template=Product_resource_table edit table]</span> || ||
|}
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===Notes===
===Notes===
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|- {{table_heading_style}}
|- {{table_heading_style}}
!Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16131570 GI:16131570]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_418157.1 GeneID:948217]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0012103
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
[http://www.uniprot.org/uniprot/P03004 UniProtKB/Swiss-Prot:P03004]
|
Escherichia coli str. K-12 substr. MG1655
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])
[[EcoCyc]]
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=PD03831 EcoCyc:PD03831] 
EcoCyc:EG10235
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://swissmodel.expasy.org/repository/ SwissModel] ([[SwissModel|EcoliWiki Page]])
[[EcoGene]]
|
|
[http://swissmodel.expasy.org/repository/smr.php?job=2&sptr_ac=P03004 SwissModel:P03004] 
EcoGene:EG10235
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[[uniprot:P03004|UniProt:P03004]] 
[http://www.ncbi.nlm.nih.gov/gene?term=948217 GeneID:948217]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418157 RefSeq:NP_418157] 
RegulonDB:ECK120000229
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|-  
|
|
[http://modbase.compbio.ucsf.edu ModBase] ([[ModBase|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://salilab.org/modbase/searchbyid?databaseID=P03004 ModBase:P03004] 
EchoBASE:EB0231
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
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<references/>
<references />
__NOTOC__
__NOTOC__
</noinclude>
===Categories===
===Categories===
{{BacktoTop}}
{{BacktoTop}}
[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0006261_!_DNA-dependent DNA replication]][[Category:GO:0005737_!_cytoplasm]][[Category:GO:0006350_!_transcription]][[Category:GO:0016564_!_transcription repressor activity]][[Category:GO:0016563_!_transcription activator activity]]

Latest revision as of 21:07, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

DnaA

Synonyms

chromosomal replication initiator protein DnaA, DNA-binding transcriptional dual regulator[1], B3702[2][1], DnaA[2][1], DNA biosynthesis; DnaA-ATP initiates chromosome replication; can be transcription regulator[2][1] , ECK3694, JW3679, b3702

Product description

DnaA transcriptional dual regulator[2][3]

DNA synthesis initiator and global transcription regulator; binds DNA at DnaA boxes, binds cardiolipin and other acidic phospholipids, binds ATP[4]

EC number (for enzymes)


edit table


Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0006275

regulation of DNA replication

PMID:12068813[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0006260

DNA replication

PMID:12068813[5]

IMP: Inferred from Mutant Phenotype

P

complete

GO:0000166

nucleotide binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001957

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018312

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003688

DNA replication origin binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00377

F

Seeded from EcoCyc (v14.0)

complete

GO:0003688

DNA replication origin binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001957

F

Seeded from EcoCyc (v14.0)

complete

GO:0003688

DNA replication origin binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018312

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00377

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001957

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013159

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018312

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

PMID:10551881[6]

IDA: Inferred from Direct Assay

F

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00377

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0963

C

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GO_REF:0000023

IEA: Inferred from Electronic Annotation

SP_SL:SL-0086

C

Seeded from EcoCyc (v14.0)

complete

GO:0006270

DNA-dependent DNA replication initiation

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00377

P

Seeded from EcoCyc (v14.0)

complete

GO:0006270

DNA-dependent DNA replication initiation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001957

P

Seeded from EcoCyc (v14.0)

complete

GO:0006270

DNA-dependent DNA replication initiation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013159

P

Seeded from EcoCyc (v14.0)

complete

GO:0006270

DNA-dependent DNA replication initiation

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018312

P

Seeded from EcoCyc (v14.0)

complete

GO:0006275

regulation of DNA replication

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00377

P

Seeded from EcoCyc (v14.0)

complete

GO:0006275

regulation of DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001957

P

Seeded from EcoCyc (v14.0)

complete

GO:0006275

regulation of DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013159

P

Seeded from EcoCyc (v14.0)

complete

GO:0006275

regulation of DNA replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR018312

P

Seeded from EcoCyc (v14.0)

complete

GO:0017111

nucleoside-triphosphatase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003593

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010921

F

Seeded from EcoCyc (v14.0)

complete

GO:0043565

sequence-specific DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR013159

F

Seeded from EcoCyc (v14.0)

complete

edit table

Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

aspS

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

cca

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

dnaJ

PMID:15690043[7]

Experiment(s):EBI-883418, EBI-890702

Protein

lpdA

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

nadE

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

rplB

PMID:15690043[7]

Experiment(s):EBI-883418, EBI-890702

Protein

rplD

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

rpsB

PMID:15690043[7]

Experiment(s):EBI-883418, EBI-890702

Protein

tufA

PMID:15690043[7]

Experiment(s):EBI-883418

Protein

rpsI

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

yfdS

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

yibL

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

rpsG

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

groL

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

dgt

PMID:16606699[8]

Experiment(s):EBI-1146527

Protein

creC

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplC

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplL

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplN

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplO

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplP

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplV

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplW

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplX

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpmB

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsC

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsE

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsG

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsI

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsJ

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsM

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsN

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rpsT

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

ynhG

PMID:15690043[7]

Experiment(s):EBI-890702

Protein

rplP

PMID:19402753[9]

LCMS(ID Probability):99.5

Protein

rpsT

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rplO

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rplN

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rpsN

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rpsD

PMID:19402753[9]

LCMS(ID Probability):95.6 MALDI(Z-score):19.412920

Protein

rpsM

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

nadE

PMID:19402753[9]

MALDI(Z-score):23.368207

Protein

rpsJ

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rplB

PMID:19402753[9]

LCMS(ID Probability):99.6 MALDI(Z-score):17.312848

Protein

tufB

PMID:19402753[9]

MALDI(Z-score):22.493646

Protein

rplX

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

rpsC

PMID:19402753[9]

LCMS(ID Probability):99.6 MALDI(Z-score):6.532571

Protein

ynhG

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

creC

PMID:19402753[9]

LCMS(ID Probability):99.0

Protein

dnaJ

PMID:19402753[9]

LCMS(ID Probability):99.6 MALDI(Z-score):17.405523

Protein

rplD

PMID:19402753[9]

LCMS(ID Probability):96.5 MALDI(Z-score):23.806084

Protein

rplL

PMID:19402753[9]

LCMS(ID Probability):99.6

Protein

Dps

PMID:18284581[10]

Affinity chromatography and solid phase binding assay

Protein

Hda

PMID:11483528[11]


edit table


Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
edit table


Notes

Structure and Physical Properties

[back to top]


Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MSLSLWQQCL ARLQDELPAT EFSMWIRPLQ AELSDNTLAL YAPNRFVLDW VRDKYLNNIN
GLLTSFCGAD APQLRFEVGT KPVTQTPQAA VTSNVAAPAQ VAQTQPQRAA PSTRSGWDNV
PAPAEPTYRS NVNVKHTFDN FVEGKSNQLA RAAARQVADN PGGAYNPLFL YGGTGLGKTH
LLHAVGNGIM ARKPNAKVVY MHSERFVQDM VKALQNNAIE EFKRYYRSVD ALLIDDIQFF
ANKERSQEEF FHTFNALLEG NQQIILTSDR YPKEINGVED RLKSRFGWGL TVAIEPPELE
TRVAILMKKA DENDIRLPGE VAFFIAKRLR SNVRELEGAL NRVIANANFT GRAITIDFVR
EALRDLLALQ EKLVTIDNIQ KTVAEYYKIK VADLLSKRRS RSVARPRQMA MALAKELTNH
SLPEIGDAFG GRDHTTVLHA CRKIEQLREE SHDIKEDFSN LIRTLSS
Length

467

Mol. Wt

52.551 kDa

pI

8.9 (calculated)

Extinction coefficient

43,890 - 44,265 (calc based on 11 Y, 5 W, and 3 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

132..350

PF00308 Bacterial dnaA protein

PMID:19920124[12]

Domain

375..444

PF08299 domain

PMID:19920124[12]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=dnaA taxon=562,83333 </beststructure>

Models

View models at:

edit table

Structure figures

Notes

Gene Product Resources

[back to top]


See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
edit table


Notes

Accessions in Other Databases

[back to top]


See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131570

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948217

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012103

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P03004

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10235

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10235

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948217

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000229

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0231

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

[back to top]




References

[back to top]


See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 Ogawa, T et al. (2002) The datA locus predominantly contributes to the initiator titration mechanism in the control of replication initiation in Escherichia coli. Mol. Microbiol. 44 1367-75 PubMed
  6. ↑ Azam, TA & Ishihama, A (1999) Twelve species of the nucleoid-associated protein from Escherichia coli. Sequence recognition specificity and DNA binding affinity. J. Biol. Chem. 274 33105-13 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 7.12 7.13 7.14 7.15 7.16 7.17 7.18 7.19 7.20 7.21 7.22 7.23 7.24 7.25 7.26 7.27 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  9. ↑ 9.00 9.01 9.02 9.03 9.04 9.05 9.06 9.07 9.08 9.09 9.10 9.11 9.12 9.13 9.14 9.15 9.16 9.17 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  10. ↑ Chodavarapu, S et al. (2008) Escherichia coli Dps interacts with DnaA protein to impede initiation: a model of adaptive mutation. Mol. Microbiol. 67 1331-46 PubMed
  11. ↑ Kato , J & Katayama, T (2001) Hda, a novel DnaA-related protein, regulates the replication cycle in Escherichia coli. EMBO J. 20 4253-62 PubMed
  12. ↑ 12.0 12.1 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

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