mutM:Gene Product(s): Difference between revisions

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*  
*  
****************************************************************************************** -->{{Product_nomenclature_help}}
****************************************************************************************** -->{{Product_nomenclature_help}}
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!align=left {{table heading style}} |Synonyms
!align=left {{table heading style}} |Synonyms
||
||
formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase<ref name='LIB:Riley_2006'/>, B3635<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fpg<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MutM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>  
''formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase<ref name='LIB:Riley_2006'/>, B3635<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, Fpg<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/>, MutM<ref name='LIB:EcoCyc10.6'/><ref name='LIB:Riley_2006'/> , ECK3625, fpg, JW3610, b3635''
|-
|-
!align=left {{table heading style}} |Product description
!align=left {{table heading style}} |Product description
Line 56: Line 56:
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23]<ref name='LIB:Riley_2006'/>
* [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.23 3.2.2.23]<ref name='LIB:Riley_2006'/>


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*  
*  
****************************************************************************************** -->{{Product_GO_help}}
****************************************************************************************** -->{{Product_GO_help}}
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{| border="2" cellpadding="4" cellspacing="0" style="margin: 1em 1em 1em 0; border: 1px #aaa solid; border-collapse: collapse;"  id="P46aaf7f9558b8"  class=" tableEdit GO_table_product dataTable"   
|- {{table_heading_style}}
|- {{table_heading_style}}
!|Qualifier!!GO ID!!GO term name!!Reference(s)!!Evidence Code!!with/from!!Aspect!!Notes!!Status
!|Qualifier!!GO ID!!GO term name!!Reference!!Evidence Code!!with/from!!Aspect!!Notes!!Status
|-
|
 
|
GO:0019104
|
DNA N-glycosylase activity
|
PMID:2664776
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0004519
|
endonuclease activity
|
PMID:2664776
|
IDA: Inferred from Direct Assay
|
 
|
F
|
nicking at AP sites
|
complete
|-  
|-  
|
|
Line 86: Line 124:
nucleic acid binding
nucleic acid binding
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 94: Line 132:
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 105: Line 143:
DNA binding
DNA binding
|
|
GO_REF:0000002<br />GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR015886<br />SP_KW:KW-0238
InterPro:IPR015887
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003677
|
DNA binding
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0238
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003684
|
damaged DNA binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR012319
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 124: Line 200:
damaged DNA binding
damaged DNA binding
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR015886
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:hamap<br />GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00103
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000191
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0008270
|
zinc ion binding
|
PMID:8473347
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000214
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0046872
|
metal ion binding
|
PMID:8473347
|
IDA: Inferred from Direct Assay
|
 
|
F
|
Cu(II), Cd(II), Hg(II) bind the protein
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 132: Line 322:
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 139: Line 329:


|
|
GO:0003824
GO:0019104
|
DNA N-glycosylase activity
|
PMID:8473347
|
|
catalytic activity
IDA: Inferred from Direct Assay
|
|
GO_REF:0000002<br />GO_REF:0000004
 
|
F
|
 
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR015886<br />SP_KW:KW-0511
InterPro:IPR015886
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
PMID:8473347
|
IDA: Inferred from Direct Assay
|
 
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
|
complete  
complete  
Line 162: Line 390:
DNA-(apurinic or apyrimidinic site) lyase activity
DNA-(apurinic or apyrimidinic site) lyase activity
|
|
GO_REF:0000003<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR015887
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
GOA:spec<br />GO_REF:0000003
|
IEA: Inferred from Electronic Annotation
|
EC:4.2.99.18
|
F
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006974
|
response to DNA damage stimulus
|
PMID:1731864
|
IDA: Inferred from Direct Assay
|
 
|
P
|
 
|
complete
|-
|
 
|
GO:0006281
|
DNA repair
|
GOA:hamap<br />GO_REF:0000020
|
IEA: Inferred from Electronic Annotation
|
HAMAP:MF_00103
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003906
|
DNA-(apurinic or apyrimidinic site) lyase activity
|
PMID:1731864
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0004519
|
endonuclease activity
|
PMID:8473347
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0006281
|
DNA repair
|
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
EC:4.2.99.18<br />HAMAP:MF_00103
InterPro:IPR000191
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0019104
|
DNA N-glycosylase activity
|
PMID:1649454
|
EXP: Inferred from Experiment
|
 
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
 
|
|
complete  
complete  
Line 181: Line 542:
DNA repair
DNA repair
|
|
GO_REF:0000002<br />GO_REF:0000004<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000214<br />SP_KW:KW-0234<br />HAMAP:MF_00103
InterPro:IPR000214
|
|
P
P
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0004519
|
endonuclease activity
|
PMID:1649454
|
EXP: Inferred from Experiment
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0004519
|
endonuclease activity
|
PMID:1731864
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0006281
|
DNA repair
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR015887
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0006281
|
DNA repair
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR020629
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0019104
|
DNA N-glycosylase activity
|
PMID:10862773
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
complete
|-
|
 
|
GO:0006281
|
DNA repair
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0234
|
P
|
Seeded from [[EcoCyc]] (v14.0)
|
complete
|-
|
 
|
GO:0003684
|
damaged DNA binding
|
PMID:10862773
|
IDA: Inferred from Direct Assay
|
 
|
F
|
 
|
|
complete  
complete  
Line 200: Line 694:
base-excision repair
base-excision repair
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 208: Line 702:
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 219: Line 713:
nucleotide-excision repair
nucleotide-excision repair
|
|
GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 227: Line 721:
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 238: Line 732:
response to DNA damage stimulus
response to DNA damage stimulus
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
Line 246: Line 740:
P
P
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 253: Line 747:


|
|
GO:0019104
GO:0008152
|
metabolic process
|
GOA:spkw<br />SP_KW:GO_REF:0000004
|
IEA: Inferred from Electronic Annotation
|
SP_KW:KW-0326
|
|
DNA N-glycosylase activity
P
|
|
PMID:2664776
Seeded from [[EcoCyc]] (v14.0)
|
|
IDA: Inferred from Direct Assay
complete
|-
|
|


|
GO:0008270
|
zinc ion binding
|
GOA:interpro<br />GO_REF:0000002
|
IEA: Inferred from Electronic Annotation
|
InterPro:IPR000191
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 276: Line 789:
zinc ion binding
zinc ion binding
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000214<br />InterPro:IPR010663<br />InterPro:IPR012319<br />InterPro:IPR015886<br />SP_KW:KW-0862
InterPro:IPR000214
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 291: Line 804:


|
|
GO:0008534
GO:0008270
|
|
oxidized purine base lesion DNA N-glycosylase activity
zinc ion binding
|
|
GO_REF:0000002<br />GO_REF:0000003<br />GO_REF:0000020
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR012319<br />EC:3.2.2.23<br />HAMAP:MF_00103
InterPro:IPR012319
|
|
F
F
|
|
Seeded from EcoCyc 12.5 <ref name = 'LIB:EcoCyc12.5'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 310: Line 823:


|
|
GO:0016787
GO:0008270
|
|
hydrolase activity
zinc ion binding
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0378
InterPro:IPR015886
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 329: Line 842:


|
|
GO:0016798
GO:0008270
|
|
hydrolase activity, acting on glycosyl bonds
zinc ion binding
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0326
InterPro:IPR015887
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 348: Line 861:


|
|
GO:0016829
GO:0008270
|
|
lyase activity
zinc ion binding
|
|
GO_REF:0000004
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0456
InterPro:IPR020629
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 367: Line 880:


|
|
GO:0046872
GO:0008270
|
|
metal ion binding
zinc ion binding
|
|
GO_REF:0000004
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
SP_KW:KW-0479
SP_KW:KW-0862
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
|-  
|-  
|
|
 
|
|
GO:0005737
GO:0008534
|
|
cytoplasm
oxidized purine base lesion DNA N-glycosylase activity
|
|
GOA:hamap<br />GO_REF:0000020
|
|
IEA: Inferred from Electronic Annotation
|
|
HAMAP:MF_00103
|
|
C
F
|
|
Seeded from EcoCyc 11.1<ref name='LIB:EcoCyc11.1'/>.  
Seeded from [[EcoCyc]] (v14.0)
|
|
required fields missing 
complete
|-  
|-  
|
|


|
|
GO:0016799
GO:0008534
|
|
hydrolase activity, hydrolyzing N-glycosyl compounds
oxidized purine base lesion DNA N-glycosylase activity
|
|
GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002<br />GO_REF:0000002
GOA:interpro<br />GO_REF:0000002
|
|
IEA: Inferred from Electronic Annotation
IEA: Inferred from Electronic Annotation
|
|
InterPro:IPR000214<br />InterPro:IPR012319<br />InterPro:IPR015886<br />InterPro:IPR015887
InterPro:IPR000191
|
|
F
F
|
|
Seeded from EcoCyc <ref name = 'LIB:EcoCyc13.0'/>
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 424: Line 937:


|
|
GO:0019104
GO:0008534
|
|
DNA N-glycosylase activity
oxidized purine base lesion DNA N-glycosylase activity
|
|
PMID:2664776
GOA:interpro<br />GO_REF:0000002
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
InterPro:IPR020629
|
|
F
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 443: Line 956:


|
|
GO:0004519
GO:0008534
|
|
endonuclease activity
oxidized purine base lesion DNA N-glycosylase activity
|
|
PMID:2664776
GOA:spec<br />GO_REF:0000003
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
EC:3.2.2.23
|
|
F
F
|
|
nicking at AP sites
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 462: Line 975:


|
|
GO:0008270
GO:0016829
|
|
zinc ion binding
lyase activity
|
|
PMID:8473347
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0456
|
|
F
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 485: Line 998:
metal ion binding
metal ion binding
|
|
PMID:8473347
GOA:spkw<br />SP_KW:GO_REF:0000004
|
|
IDA: Inferred from Direct Assay
IEA: Inferred from Electronic Annotation
|
|
 
SP_KW:KW-0479
|
|
F
F
|
|
Cu(II), Cd(II), Hg(II) bind the protein
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  
Line 500: Line 1,013:


|
|
GO:0019104
GO:0046872
|
|
DNA N-glycosylase activity
metal ion binding
|
|
8473347
PMID:8473347
|
|
IDA: Inferred from Direct Assay
IDA: Inferred from Direct Assay
Line 512: Line 1,025:
F
F
|
|
 
Seeded from [[EcoCyc]] (v14.0)
|
|
complete  
complete  


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!|Partner Type!!Partner!!Notes!!References!!Evidence
!|Partner Type!!Partner!!Notes!!References!!Evidence
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|
|
Experiment(s):EBI-1146365<br />  
Experiment(s):EBI-1146365<br />  
|-
|
Protein
|
mscL
|
|
PMID:19402753
|
LCMS(ID Probability):98.9
|-
|
Small Molecule
|
PMPS
|
Inhibitor
|
PMID:8473347
|
Activity Assays


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|- {{table heading style}}
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!|Compartment!!Description!!Evidence!!Source!!Notes
!|Compartment!!Description!!Evidence!!Reference/Source!!Notes


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39,420 - 40,170 (calc based on 8 Y, 5 W, and 6 C residues)
39,420 - 40,170 (calc based on 8 Y, 5 W, and 6 C residues)


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!|Type!!Residues!!Description!!Notes
!|Type!!Residues!!Description!!Notes!!References
|-  
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|
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Removed
Removed
|
|
[http://www.uniprot.org/uniprot/P05523#section_features UniProt:P05523]  
[http://www.uniprot.org/uniprot/P05523#section_features UniProt:P05523]
|
|-
|
Domain
|
2..115
|
[http://pfam.janelia.org/family/PF01149 PF01149  Formamidopyrimidine-DNA glycosylase N-terminal domain]
|
 
|
PMID:19920124
|-
|
Domain
|
241..269
|
[http://pfam.janelia.org/family/PF06827 PF06827  Zinc finger found in FPG and IleRS]
|


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PMID:19920124
|-
|
Domain
|
129..220
|
[http://pfam.janelia.org/family/PF06831 PF06831  Formamidopyrimidine-DNA glycosylase H2TH domain]
|
 
|
PMID:19920124
 
|- class="tableEdit_footer"
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View models at:
View models at:
* [http://dragon.bio.purdue.edu/ecolpredict2/localsearch/cgi-bin/search3.cgi?q=recA EcoliPredict]
* [http://www.proteinmodelportal.org/query/uniprot/P05523 Protein Model Portal]
* [http://modbase.compbio.ucsf.edu/modbase-cgi/model_search.cgi?searchmode=default&displaymode=moddetail&searchproperties=ALL&searchvalue=recA&organism=562&organismtext= ModBase]
* [http://bioinf.cs.ucl.ac.uk/genome3d/read?uniprot_id=P05523 PSI-PRED (P05523)]
* [http://bioinf.cs.ucl.ac.uk/psipred/ PSI-PRED]
* [http://spock.genes.nig.ac.jp/~genome/cgi-bin/gkeytext.pl.cgi?A&QUERY1=P05523 Genomes TO Protein (P05523)] (GTOP)
* [http://www.ebi.ac.uk/msd-srv/pqs/ Protein Quaternary Structure] (PQS)
* [http://spock.genes.nig.ac.jp/~genome/search.html Genomes TO Protein] (GTOP)


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!|Resource type!!Source!!Notes/Reference
!|Resource type!!Source!!Notes/Reference


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|- {{table_heading_style}}
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!|Database!!Accession!!Notes
!|Database!!Accession!!Notes
|-  
|-  
|
|
[http://ecocyc.org EcoCyc] ([[EcoCyc|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/16131506 GI:16131506]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[http://www.ncbi.nlm.nih.gov/protein NCBI (Protein)] ([[NCBI (Protein)|EcoliWiki Page]])
|
[http://www.ncbi.nlm.nih.gov/protein/NP_418092.1 GeneID:946765]
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[ASAP]]
|
ASAP:ABE-0011877
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[http://www.pir.uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])
|
|
[http://biocyc.org/ECOLI/NEW-IMAGE?type=NIL&object=EG10329-MONOMER EcoCyc:EG10329-MONOMER]
[http://www.uniprot.org/uniprot/P05523 UniProtKB/Swiss-Prot:P05523]
|
|
Escherichia coli str. K-12 substr. MG1655
|-
|
[[EcoCyc]]
|
EcoCyc:EG10329
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-
|
[[EcoGene]]
|
EcoGene:EG10329
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://uniprot.org/ UniProt] ([[UniProt|EcoliWiki Page]])  
[http://www.ncbi.nlm.nih.gov/gene NCBI (Gene)] ([[NCBI (Gene)|EcoliWiki Page]])
|
|
[[uniprot:P05523|UniProt:P05523]]
[http://www.ncbi.nlm.nih.gov/gene?term=946765 GeneID:946765]
|
|
Escherichia coli str. K-12 substr. MG1655
|-  
|-  
|
|
[http://pfam.sanger.ac.uk/ PFAM] ([[PFAM|EcoliWiki Page]])
[[RegulonDB]]
|
|
[http://pfam.sanger.ac.uk/family?acc=PF01149 PFAM:PF01149]
RegulonDB:ECK120000323
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]
|-  
|-  
|
|
[http://www.ncbi.nlm.nih.gov/RefSeq/ RefSeq] ([[RefSeq|EcoliWiki Page]])
[[EchoBASE]]
|
|
[http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nucleotide&val=NP_418092 RefSeq:NP_418092]
EchoBASE:EB0325
|
|
''Escherichia coli'' str. K-12 substr. [[:Category:Strain:MG1655|MG1655]]


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!|Name!!URL!!Comments
!|Name!!URL!!Comments


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{{BacktoTop}}
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[[Category:Proteins]]
[[Category:Proteins]]
[[Category:GO:0005737_!_cytoplasm]][[Category:GO:0006281_!_DNA repair]][[Category:Products with structures in PDB]]

Latest revision as of 21:06, 17 February 2015

{{#css:Suppresslinks.css}}<css>h1 .editsection { display:none;} h2 .editsection { display:none;}</css>

Quickview   Gene   Gene Product(s)   Expression   Evolution   On One Page    
Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

MutM

Synonyms

formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase[1], B3635[2][1], Fpg[2][1], MutM[2][1] , ECK3625, fpg, JW3610, b3635

Product description

formamidopyrimidine DNA glycosylase[2][3]

Formamidopyrimidine-DNA glycosylase/AP lyase; 5'-terminal deoxyribophosphodiesterase; DNA repair; GC to TA; binds Zn(II)[4]

EC number (for enzymes)
edit table


Notes

Function

[back to top]


Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0019104

DNA N-glycosylase activity

PMID:2664776[5]

IDA: Inferred from Direct Assay

F

complete

GO:0004519

endonuclease activity

PMID:2664776[5]

IDA: Inferred from Direct Assay

F

nicking at AP sites

complete

GO:0003676

nucleic acid binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR010979

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015887

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0003684

damaged DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012319

F

Seeded from EcoCyc (v14.0)

complete

GO:0003684

damaged DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015886

F

Seeded from EcoCyc (v14.0)

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00103

F

Seeded from EcoCyc (v14.0)

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000191

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000214

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

Cu(II), Cd(II), Hg(II) bind the protein

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012319

F

Seeded from EcoCyc (v14.0)

complete

GO:0019104

DNA N-glycosylase activity

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015886

F

Seeded from EcoCyc (v14.0)

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015887

F

Seeded from EcoCyc (v14.0)

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:4.2.99.18

F

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

PMID:1731864[7]

IDA: Inferred from Direct Assay

P

complete

GO:0006281

DNA repair

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00103

P

Seeded from EcoCyc (v14.0)

complete

GO:0003906

DNA-(apurinic or apyrimidinic site) lyase activity

PMID:1731864[7]

IDA: Inferred from Direct Assay

F

complete

GO:0004519

endonuclease activity

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000191

P

Seeded from EcoCyc (v14.0)

complete

GO:0019104

DNA N-glycosylase activity

PMID:1649454[8]

EXP: Inferred from Experiment

F

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000214

P

Seeded from EcoCyc (v14.0)

complete

GO:0004519

endonuclease activity

PMID:1649454[8]

EXP: Inferred from Experiment

F

complete

GO:0004519

endonuclease activity

PMID:1731864[7]

IDA: Inferred from Direct Assay

F

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015887

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020629

P

Seeded from EcoCyc (v14.0)

complete

GO:0019104

DNA N-glycosylase activity

PMID:10862773[9]

IDA: Inferred from Direct Assay

F

complete

GO:0006281

DNA repair

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded from EcoCyc (v14.0)

complete

GO:0003684

damaged DNA binding

PMID:10862773[9]

IDA: Inferred from Direct Assay

F

complete

GO:0006284

base-excision repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012319

P

Seeded from EcoCyc (v14.0)

complete

GO:0006289

nucleotide-excision repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015886

P

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

Seeded from EcoCyc (v14.0)

complete

GO:0008152

metabolic process

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0326

P

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000191

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000214

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR012319

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015886

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR015887

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020629

F

Seeded from EcoCyc (v14.0)

complete

GO:0008270

zinc ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0862

F

Seeded from EcoCyc (v14.0)

complete

GO:0008534

oxidized purine base lesion DNA N-glycosylase activity

GOA:hamap
GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_00103

F

Seeded from EcoCyc (v14.0)

complete

GO:0008534

oxidized purine base lesion DNA N-glycosylase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000191

F

Seeded from EcoCyc (v14.0)

complete

GO:0008534

oxidized purine base lesion DNA N-glycosylase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR020629

F

Seeded from EcoCyc (v14.0)

complete

GO:0008534

oxidized purine base lesion DNA N-glycosylase activity

GOA:spec
GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:3.2.2.23

F

Seeded from EcoCyc (v14.0)

complete

GO:0016829

lyase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0456

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0479

F

Seeded from EcoCyc (v14.0)

complete

GO:0046872

metal ion binding

PMID:8473347[6]

IDA: Inferred from Direct Assay

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

glpT

PMID:16606699[10]

Experiment(s):EBI-1146365

Protein

thiI

PMID:16606699[10]

Experiment(s):EBI-1146365

Protein

ilvI

PMID:16606699[10]

Experiment(s):EBI-1146365

Protein

mscL

PMID:19402753[11]

LCMS(ID Probability):98.9

Small Molecule

PMPS

Inhibitor

PMID:8473347[6]

Activity Assays

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MPELPEVETS RRGIEPHLVG ATILHAVVRN GRLRWPVSEE IYRLSDQPVL SVQRRAKYLL
LELPEGWIII HLGMSGSLRI LPEELPPEKH DHVDLVMSNG KVLRYTDPRR FGAWLWTKEL
EGHNVLTHLG PEPLSDDFNG EYLHQKCAKK KTAIKPWLMD NKLVVGVGNI YASESLFAAG
IHPDRLASSL SLAECELLAR VIKAVLLRSI EQGGTTLKDF LQSDGKPGYF AQELQVYGRK
GEPCRVCGTP IVATKHAQRA TFYCRQCQK
Length

269

Mol. Wt

30.29 kDa

pI

8.6 (calculated)

Extinction coefficient

39,420 - 40,170 (calc based on 8 Y, 5 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Initiator Methionine

1

Removed

UniProt:P05523

Domain

2..115

PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain

PMID:19920124[12]

Domain

241..269

PF06827 Zinc finger found in FPG and IleRS

PMID:19920124[12]

Domain

129..220

PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain

PMID:19920124[12]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=mutM taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131506

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:946765

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0011877

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P05523

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG10329

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG10329

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:946765

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120000323

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB0325

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.0 2.1 2.2 2.3 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.0 5.1 O'Connor, TR & Laval, J (1989) Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc. Natl. Acad. Sci. U.S.A. 86 5222-6 PubMed
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 O'Connor, TR et al. (1993) Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role. J. Biol. Chem. 268 9063-70 PubMed
  7. ↑ 7.0 7.1 7.2 Boiteux, S et al. (1992) Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Biochemistry 31 106-10 PubMed
  8. ↑ 8.0 8.1 Michaels, ML et al. (1991) MutM, a protein that prevents G.C----T.A transversions, is formamidopyrimidine-DNA glycosylase. Nucleic Acids Res. 19 3629-32 PubMed
  9. ↑ 9.0 9.1 Hazra, TK et al. (2000) Characterization of a novel 8-oxoguanine-DNA glycosylase activity in Escherichia coli and identification of the enzyme as endonuclease VIII. J. Biol. Chem. 275 27762-7 PubMed
  10. ↑ 10.0 10.1 10.2 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  11. ↑ Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  12. ↑ 12.0 12.1 12.2 Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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