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On One Page

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Gene |

Product(s) |

Expression|

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Standard Name	viaA
Gene Synonym(s)	yieM, ECK3739, b3745, JW5610, yieD, yieD_1, yieD_2^[1]^[2]
Product Desc.	stimulator of RavA ATPase activity^[2]^[3] Stimulator of RavA ATPase activity^[4]
Product Synonyms(s)	predicted von Willibrand factor containing protein^[1], B3745^[2]^[1], YieD^[2]^[1], YieM^[2]^[1], ViaA^[2]^[1] , ECK3739, JW5610, yieD, yieM, b3745
Function from GO	<GO_nr />
Knock-Out Phenotype
Regulation/Expression	transcription unit(s): yieM^[2]
Regulation/Activity
Quick Links
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Notes

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Stimulates RavA ATPase 2-fold in vitro. Contains a Von Willebrand Factor Type A (VWA) domain. In rpoS-regulated operon with ravA. Mutants have elevated OM vesiculation (McBroom, 2006).^[4]

Gene

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Nomenclature

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See Help:Gene_nomenclature for help with entering information in the Gene Nomenclature table.

Standard name	viaA
Mnemonic	VWA interacting with AAA+ ATPase
Synonyms	yieM, ECK3739, b3745, JW5610, yieD, yieD_1, yieD_2^[1]^[2]
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Notes

Location(s) and DNA Sequence

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<protect> See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	84.62 minutes	MG1655: 3927626..3926175 <gbrowseImage> name=NC_000913:3926175..3927626 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 3888513..3889964 <gbrowseImage> name=NC_012967:3888513..3889964 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 3814508..3815959 <gbrowseImage> name=NC_012759:3814508..3815959 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 3707078..3708529 <gbrowseImage> name=NC_007779:3707078..3708529 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
DH10B		DH10B: 4025210..4023759 <gbrowseImage> name=NC_010473:4023759..4025210 source=DH10B preset=GeneLocation </gbrowseImage>	GBrowse(DH10B)	FASTA Dump
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Notes

Sequence Features

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See Help:Gene_sequence_features for help in entering sequence features in EcoliWiki.

Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Notes

Alleles and Phenotypes

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See Help:Gene_alleles for how to enter or edit alleles and phenotypes in EcoliWiki.

Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔviaA774::kan					PMID:16738554	CGSC:106376
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Notes

Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Notes

Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource

Resource Type

Source

Notes/Reference

Plasmid clone

Shigen

PMID:16769691

Status:

Primer 1:

Primer 2:

4F4

Kohara Phage

Genobase

PMID:3038334

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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11730	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11730	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001669	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:948257	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1681	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012244	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Product(s)

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Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name	YieM
Synonyms	predicted von Willibrand factor containing protein^[1], B3745^[2]^[1], YieD^[2]^[1], YieM^[2]^[1], ViaA^[2]^[1] , ECK3739, JW5610, yieD, yieM, b3745
Product description	stimulator of RavA ATPase activity^[2]^[3] Stimulator of RavA ATPase activity^[4]
EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	tufA	PMID:15690043	Experiment(s):EBI-881016
Protein	yniC	PMID:15690043	Experiment(s):EBI-881016
Protein	pflB	PMID:19402753	MALDI(Z-score):18.692607
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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MLTLDTLNVM LAVSEEGLIE EMIIALLASP QLAVFFEKFP RLKAAITDDV PRWREALRSR LKDARVPPEL TEEVMCYQQS QLLSTPQFIV QLPQILDLLH RLNSPWAEQA RQLVDANSTI TSALHTLFLQ RWRLSLIVQA TTLNQQLLEE EREQLLSEVQ ERMTLSGQLE PILADNNTAA GRLWDMSAGQ LKRGDYQLIV KYGEFLNEQP ELKRLAEQLG RSREAKSIPR NDAQMETFRT MVREPATVPE QVDGLQQSDD ILRLLPPELA TLGITELEYE FYRRLVEKQL LTYRLHGESW REKVIERPVV HKDYDEQPRG PFIVCVDTSG SMGGFNEQCA KAFCLALMRI ALAENRRCYI MLFSTEIVRY ELSGPQGIEQ AIRFLSQQFR GGTDLASCFR AIMERLQSRE WFDADAVVIS DFIAQRLPDD VTSKVKELQR VHQHRFHAVA MSAHGKPGIM RIFDHIWRFD TGMRSRLLRR WRR
Length	483
Mol. Wt	55.908 kDa
pI	6.5 (calculated)
Extinction coefficient	57,410 - 58,160 (calc based on 9 Y, 8 W, and 6 C residues)
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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type	Residues	Description	Notes	References
Domain	284..465	PF05762 VWA domain containing CoxE-like protein		PMID:19920124
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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=viaA taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type	Source	Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:49176398	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:948257	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012244	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P0ADN0	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:EG11730	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG11730	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:948257	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001669	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1681	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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See Help:Cellular levels

Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	Ecoli K-12	2.448+/-0.03	Molecules/cell	Medium: Temperature (°C): Doubling time (min): Growth Rate(min): * Growth phase: other: *		Single Molecule Fluorescence	PMID:20671182
Protein	E. coli K-12 MG1655	38	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	33	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	18^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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See Help:Expression_transcription for help entering or editing information in this section of EcoliWiki.

Transcription unit(s)
yieM
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Figure courtesy of RegulonDB

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Notes

This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<protect><gbrowseImage> name=NC_000913:3927606..3927646 source=MG1655 flip=1 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

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Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

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Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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<protect> Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b3745 (EcoliWiki Page)	NCBI GEO profiles for viaA
microarray	GenExpDB:b3745 (EcoliWiki Page)	Summary of data for viaA from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to viaA Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:EG11730	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB1681	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b3745
EcoGene	EcoGene:EG11730	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120001669	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0012244	Escherichia coli str. K-12 substr. MG1655
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Notes

Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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See Help:Evolution_homologs for help entering or editing information in this section of EcoliWiki.

Organism	Homologs (Statistics)	Comments
Shigella flexneri	YIEM	From SHIGELLACYC
E. coli O157	YIEM	From ECOO157CYC
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Notes

Families

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<protect> See Help:Evolution_families for help entering or editing information in this section of EcoliWiki.

Database	Accession	Notes
Pfam (EcoliWiki Page)	PF05762 VWA domain containing CoxE-like protein
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Notes

Links

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Name	URL	Comments
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References

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See Help:References for how to manage references in EcoliWiki.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 ^4.2 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.

viaA:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

Notes

Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to viaA Expression

Notes

Links

Evolution

Homologs in Other Organisms

Notes

Families

Notes

Links

References

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