uvrD:Gene Product(s)

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Nomenclature Function Interactions Localization Sequence Domains Structure Resources Accessions Links References Suggestions

Nomenclature

See Help:Product_nomenclature for help entering or editing information in this section of EcoliWiki.

Standard name

UvrD

Synonyms

DNA-dependent ATPase I and helicase II[1], B3813[2][1], UvrE[2][1], SrjC[2][1], Rad[2][1], Dda[2][1], RecL[2][1], PdeB[2][1], MutU[2][1], UvrD[2][1] , dar-2, dda, ECK3808, JW3786, mutU, pdeB, rad, recL, srjC, uvr502, uvrE, b3813

Product description

DNA-dependent ATPase I and helicase II[2][3];

Component of UvrABC Nucleotide Excision Repair Complex[2][3]

ATP-dependent 3'-5' DNA helicase II; unwinds forked DNA structures; dismantles the RecA nucleoprotein filament; increased rates of spontaneous mutagenesis[4]

EC number (for enzymes)
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Notes

Function

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<protect> Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0547

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0003677

DNA binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0238

F

Seeded from EcoCyc (v14.0)

complete

GO:0004003

ATP-dependent DNA helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0004003

ATP-dependent DNA helicase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005753

F

Seeded from EcoCyc (v14.0)

complete

GO:0004386

helicase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0347

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014016

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014017

F

Seeded from EcoCyc (v14.0)

complete

GO:0005524

ATP binding

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0067

F

Seeded from EcoCyc (v14.0)

complete

GO:0005737

cytoplasm

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005753

C

Seeded from EcoCyc (v14.0)

complete

GO:0006260

DNA replication

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0235

P

Seeded from EcoCyc (v14.0)

complete

GO:0006268

DNA unwinding involved in replication

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR005753

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000212

P

Seeded from EcoCyc (v14.0)

complete

GO:0006281

DNA repair

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0234

P

Seeded from EcoCyc (v14.0)

complete

GO:0006974

response to DNA damage stimulus

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0227

P

Seeded from EcoCyc (v14.0)

complete

GO:0009432

SOS response

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0742

P

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014016

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:interpro
GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014017

F

Seeded from EcoCyc (v14.0)

complete

GO:0016787

hydrolase activity

GOA:spkw
SP_KW:GO_REF:0000004

IEA: Inferred from Electronic Annotation

SP_KW:KW-0378

F

Seeded from EcoCyc (v14.0)

complete

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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type Partner Notes References Evidence

Protein

Subunits of UvrABC Nucleotide Excision Repair Complex

could be indirect

Protein

lpdA

PMID:15690043[5]

Experiment(s):EBI-881212, EBI-888366

Protein

metE

PMID:16606699[6]

Experiment(s):EBI-1146727

Protein

ssnA

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

clpA

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

dgt

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

fis

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

hns

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

hupA

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

hupB

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

malP

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

pepN

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rplC

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rplL

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rplM

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rplV

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rplW

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpmC

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpoB

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpsB

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpsE

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpsF

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpsG

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

rpsN

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

secA

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

tgt

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

metN

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

accA

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

aceE

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

aceF

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

araG

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

agaR

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

pqiB

PMID:15690043[5]

Experiment(s):EBI-888366

Protein

metN

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

malP

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

pepN

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

tgt

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

rpoB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

fis

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

clpA

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

pqiB

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

agaR

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

araG

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

ssnA

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

dgt

PMID:19402753[7]

LCMS(ID Probability):99.0

Protein

MutL

PMID:9880500[8]

2 Hybrid Screen

Protein

MutL

C-terminal 218 amino acids of MutL were sufficient to produce the two-hybrid interaction with UvrD

PMID:9482750[9]

2 Hybrid Screen

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Notes

Localization

See Help:Product_localization for how to add or edit information in this section of EcoliWiki.

Compartment Description Evidence Reference/Source Notes
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Notes

Structure and Physical Properties

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<protect> Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence

at EcoCyc 

MDVSYLLDSL NDKQREAVAA PRSNLLVLAG AGSGKTRVLV HRIAWLMSVE NCSPYSIMAV
TFTNKAAAEM RHRIGQLMGT SQGGMWVGTF HGLAHRLLRA HHMDANLPQD FQILDSEDQL
RLLKRLIKAM NLDEKQWPPR QAMWYINSQK DEGLRPHHIQ SYGNPVEQTW QKVYQAYQEA
CDRAGLVDFA ELLLRAHELW LNKPHILQHY RERFTNILVD EFQDTNNIQY AWIRLLAGDT
GKVMIVGDDD QSIYGWRGAQ VENIQRFLND FPGAETIRLE QNYRSTSNIL SAANALIENN
NGRLGKKLWT DGADGEPISL YCAFNELDEA RFVVNRIKTW QDNGGALAEC AILYRSNAQS
RVLEEALLQA SMPYRIYGGM RFFERQEIKD ALSYLRLIAN RNDDAAFERV VNTPTRGIGD
RTLDVVRQTS RDRQLTLWQA CRELLQEKAL AGRAASALQR FMELIDALAQ ETADMPLHVQ
TDRVIKDSGL RTMYEQEKGE KGQTRIENLE ELVTATRQFS YNEEDEDLMP LQAFLSHAAL
EAGEGQADTW QDAVQLMTLH SAKGLEFPQV FIVGMEEGMF PSQMSLDEGG RLEEERRLAY
VGVTRAMQKL TLTYAETRRL YGKEVYHRPS RFIGELPEEC VEEVRLRATV SRPVSHQRMG
TPMVENDSGY KLGQRVRHAK FGEGTIVNME GSGEHSRLQV AFQGQGIKWL VAAYARLESV
Length

720

Mol. Wt

81.99 kDa

pI

6.2 (calculated)

Extinction coefficient

105,770 - 106,520 (calc based on 23 Y, 13 W, and 6 C residues)

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Domains/Motifs/Modification Sites

See Help:Product_domains_motifs for help entering or editing information in this section of EcoliWiki.

Type Residues Description Notes References

Domain

10..490

PF00580 UvrD/REP helicase

PMID:19920124[10]

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<motif_map/>

Structure
See Help:Product_structure for help entering or editing information in this section of EcoliWiki.

Structures

<beststructure> gene=uvrD taxon=562,83333 </beststructure>

Models

View models at:

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Structure figures

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Notes

Gene Product Resources

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See Help:Product_resources for help with entering or editing information in this section of EcoliWiki.

Resource type Source Notes/Reference
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Notes

Accessions in Other Databases

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database Accession Notes

NCBI (Protein) (EcoliWiki Page)

GI:16131665

Escherichia coli str. K-12 substr. MG1655

NCBI (Protein) (EcoliWiki Page)

GeneID:948347

Escherichia coli str. K-12 substr. MG1655

ASAP

ASAP:ABE-0012455

Escherichia coli str. K-12 substr. MG1655

UniProt (EcoliWiki Page)

UniProtKB/Swiss-Prot:P03018

Escherichia coli str. K-12 substr. MG1655

EcoCyc

EcoCyc:EG11064

Escherichia coli str. K-12 substr. MG1655

EcoGene

EcoGene:EG11064

Escherichia coli str. K-12 substr. MG1655

NCBI (Gene) (EcoliWiki Page)

GeneID:948347

Escherichia coli str. K-12 substr. MG1655

RegulonDB

RegulonDB:ECK120001053

Escherichia coli str. K-12 substr. MG1655

EchoBASE

EchoBASE:EB1057

Escherichia coli str. K-12 substr. MG1655

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Notes

Links

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References

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See Help:References for how to manage references in EcoliWiki.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  3. ↑ 3.0 3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
  4. ↑ EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
  5. ↑ 5.00 5.01 5.02 5.03 5.04 5.05 5.06 5.07 5.08 5.09 5.10 5.11 5.12 5.13 5.14 5.15 5.16 5.17 5.18 5.19 5.20 5.21 5.22 5.23 5.24 5.25 5.26 5.27 5.28 5.29 5.30 Butland, G et al. (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433 531-7 PubMed
  6. ↑ Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
  7. ↑ 7.00 7.01 7.02 7.03 7.04 7.05 7.06 7.07 7.08 7.09 7.10 7.11 Hu, P et al. (2009) Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. PLoS Biol. 7 e96 PubMed
  8. ↑ Hall, MC & Matson, SW (1999) The Escherichia coli MutL protein physically interacts with MutH and stimulates the MutH-associated endonuclease activity. J. Biol. Chem. 274 1306-12 PubMed
  9. ↑ Hall, MC et al. (1998) Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17 1535-41 PubMed
  10. ↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

Categories

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