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Standard Name	uspC
Gene Synonym(s)	yecG, ECK1894, b1895, JW1884^[1]^[2], JW1884
Product Desc.	universal stress protein^[2]^[3] Stress-induced protein; UV-resistance^[4]
Product Synonyms(s)	universal stress protein^[1], B1895^[2]^[1], UspC^[2]^[1], YecG^[2]^[1] , ECK1894, JW1884, yecG, b1895
Function from GO	<GO_nr />
Knock-Out Phenotype	UspC null mutants lack flagella and are thus completely nonmotile (Nachin et al, 2005; PMID:16159758^[5]). UspC null mutants also are sensitive to UV irradiation (Gustavsson et al, 2002; PMID:11849540^[6])
Regulation/Expression	transcription unit(s): uspC^[2]
Regulation/Activity	Upregulated in response to a variety of stressors in a ppGpp dependent manner (Gustavsson et al, 2002; PMID:11849540^[6]).
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Notes

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Gene

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Nomenclature

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Standard name	uspC
Mnemonic	Universal stress protein
Synonyms	yecG, ECK1894, b1895, JW1884^[1]^[2], JW1884
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Notes

Location(s) and DNA Sequence

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See Help:Gene_location for help entering information in the Gene Location and DNA sequence table.

Strain	Map location	Genome coordinates	Genome browsers	Sequence links
MG1655	42.63 minutes	MG1655: 1977777..1978205 <gbrowseImage> name=NC_000913:1977777..1978205 source=MG1655 preset=GeneLocation </gbrowseImage>	EcoCyc GBrowse(MG1655)	FASTA Dump EcoCyc Sequence Dump
REL606		NC_012967: 1957747..1958175 <gbrowseImage> name=NC_012967:1957747..1958175 source=REL606 preset=GeneLocation </gbrowseImage>	GBrowse (REL606)	FASTA Dump
BW2952		NC_012759: 1870260..1870688 <gbrowseImage> name=NC_012759:1870260..1870688 source=BW2952 preset=GeneLocation </gbrowseImage>	GBrowse (BW2952)	FASTA Dump
W3110		W3110: 1981890..1982318 <gbrowseImage> name=NC_007779:1981890..1982318 source=W3110 preset=GeneLocation </gbrowseImage>	GBrowse(W3110)	FASTA Dump
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Notes

Sequence Features

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Feature Type	Strain	Genomic Location	Evidence	Reference	Notes
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Alleles and Phenotypes

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Allele	Nt change(s)	AA change(s)	Phenotype: Type	Phenotype: Description	Reference	Availability	Comments
ΔuspC746::kan					PMID:16738554	CGSC:106372
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Genetic Interactions

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Interactor	Interaction	Allele	Score(s)	Reference(s)	Accessions	Notes
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Genetic Resources

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See Help:Gene_resources for help entering information into the Genetic Resources table.

Resource	Resource Type	Source	Notes/Reference
	Plasmid clone	Shigen	PMID:16769691 Status: Primer 1: Primer 2:
7F11	Kohara Phage	Genobase	PMID:3038334
18A9	Kohara Phage	Genobase	PMID:3038334
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Notes

Accessions in Other Databases

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Database	Accession	Notes
EcoCyc	EcoCyc:G7031	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12862	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003618	Escherichia coli str. K-12 substr. MG1655
NCBI (EcoliWiki Page)	GeneID:946404	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2704	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006316	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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Product(s)

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Nomenclature

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Standard name	YecG
Synonyms	universal stress protein^[1], B1895^[2]^[1], UspC^[2]^[1], YecG^[2]^[1] , ECK1894, JW1884, yecG, b1895
Product description	universal stress protein^[2]^[3] Stress-induced protein; UV-resistance^[4]
EC number (for enzymes)
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Notes

Function

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Gene Ontology
See Help:Gene_ontology for help entering or editing GO terms and GO annotations in EcoliWiki.

Qualifier	GO ID	GO term name	Reference	Evidence Code	with/from	Aspect	Notes	Status
	GO:0005737	cytoplasm	GOA:spkw SP_KW:GO_REF:0000004	IEA: Inferred from Electronic Annotation	SP_KW:KW-0963	C	Seeded from EcoCyc (v14.0)	complete
	GO:0005737	cytoplasm	GO_REF:0000023	IEA: Inferred from Electronic Annotation	SP_SL:SL-0086	C	Seeded from EcoCyc (v14.0)	complete
	GO:0006950	response to stress	GOA:interpro GO_REF:0000002	IEA: Inferred from Electronic Annotation	InterPro:IPR006016	P	Seeded from EcoCyc (v14.0)	complete
	GO:0032947	protein complex scaffold	PMID:19101563^[7]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc (v14.0)	complete
	GO:0032947	protein complex scaffold	PMID:19589130^[8]	IDA: Inferred from Direct Assay		F	Seeded from EcoCyc (v14.0)	complete
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Interactions See Help:Product_interactions for help entering or editing information about gene product interactions in this section of EcoliWiki.

Partner Type	Partner	References	Evidence
Protein	insN1	PMID:16606699^[9]	Experiment(s):EBI-1141234
Protein	rpsM	PMID:16606699^[9]	Experiment(s):EBI-1141234
Protein	racC	PMID:16606699^[9]	Experiment(s):EBI-1141234
Protein	rplS	PMID:16606699^[9]	Experiment(s):EBI-1141234
Protein	rpmB	PMID:16606699^[9]	Experiment(s):EBI-1141234
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Notes

Localization

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Compartment	Description	Evidence	Reference/Source	Notes
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Notes

Structure and Physical Properties

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Physical Properties See Help:Product_physical_properties for help entering or editing information about the physical properties of this gene product.

Name
Sequence	at EcoCyc MSYSNILVAV AVTPESQQLL AKAVSIARPV KGHISLITLA SDPEMYNQLA APMLEDLRSV MHEETQSFLD KLIQDAGYPV DKTFIAYGEL SEHILEVCHK HHFDLVICGN HNHSFFSRAS CSAKRVIASS EVDVLLVPLT GD
Length	142
Mol. Wt	15.632 kDa
pI	5.8 (calculated)
Extinction coefficient	5,960 - 6,335 (calc based on 4 Y, 0 W, and 3 C residues)
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Domains/Motifs/Modification Sites

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Type	Residues	Description	Notes	References
Domain	2..138	PF00582 Universal stress protein family		PMID:19920124^[10]
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<motif_map/>

Structure
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Structures

<beststructure> gene=uspC taxon=562,83333 </beststructure>

Models

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Structure figures

Notes

Gene Product Resources

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Resource type	Source	Notes/Reference
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Accessions in Other Databases

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Database	Accession	Notes
NCBI (Protein) (EcoliWiki Page)	GI:16129847	Escherichia coli str. K-12 substr. MG1655
NCBI (Protein) (EcoliWiki Page)	GeneID:946404	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006316	Escherichia coli str. K-12 substr. MG1655
UniProt (EcoliWiki Page)	UniProtKB/Swiss-Prot:P46888	Escherichia coli str. K-12 substr. MG1655
EcoCyc	EcoCyc:G7031	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12862	Escherichia coli str. K-12 substr. MG1655
NCBI (Gene) (EcoliWiki Page)	GeneID:946404	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003618	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2704	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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Expression

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Overview

This is a placeholder for a summary statement on how expression of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Cellular Levels

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Molecule	Organism or Strain	Value	Units	Experimental Conditions	Assay used	Notes	Reference(s)
Protein	E. coli K-12 MG1655	52	molecules/cell/generation	Medium: MOPS Complete Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	102	molecules/cell/generation	Medium: MOPS Minimal Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling		PMID: 24766808
Protein	E. coli K-12 MG1655	67^a	molecules/cell/generation	Medium: MOPS Complete without Methionine Temperature (°C): 37 Doubling time (min): *Growth phase: OD: other:	Ribosome Profiling	Low confidence in the sequencing data set.	PMID: 24766808
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Notes

Transcription and Transcriptional Regulation

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Transcription unit(s)
uspC
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This is a placeholder for a summary statement about how transcription of this gene is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Translation and Regulation of Translation

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<gbrowseImage> name=NC_000913:1977757..1977797 source=MG1655 type=Gene+DNA_+Protein preset=Nterminus </gbrowseImage> This picture shows the sequence around the N-terminus.

Notes

This is a placeholder for a summary statement about how translation of this gene product is regulated. You can help EcoliWiki by becoming a user and writing/editing this statement.

Turnover and Regulation of Turnover

</protect>

Notes

This is a placeholder for a summary statement about turnover of this gene product. You can help EcoliWiki by becoming a user and writing/editing this statement.

Experimental

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Mutations Affecting Expression See Help:Expression_mutations for help entering or editing information in this section of EcoliWiki.

Allele Name	Mutation	Phenotype	Reference
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Expression Studies See Help:Expression_studies for help entering or editing information in this section of EcoliWiki.

Type	Reference	Notes
microarray	GEO Profiles:b1895 (EcoliWiki Page)	NCBI GEO profiles for uspC
microarray	GenExpDB:b1895 (EcoliWiki Page)	Summary of data for uspC from multiple microarray studies
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Expression Resources See Help:Expression_resources for help entering or editing information in this section of EcoliWiki.

Resource Name	Resource Type	Description	Source	Notes
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Notes

Accessions Related to uspC Expression

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
EcoCyc	EcoCyc:G7031	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2704	Escherichia coli str. K-12 substr. MG1655
EcoliGenExpDB (EcoliWiki Page)	EcoliGenExpDB:b1895
EcoGene	EcoGene:EG12862	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003618	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006316	Escherichia coli str. K-12 substr. MG1655
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Links

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Name	URL	Comments
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Evolution

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Homologs in Other Organisms

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Organism	Homologs (Statistics)	Comments
Xenopus tropicalis	ENSXETP00000011151 (score: 1.000; bootstrap: 100%) ENSXETP00000044915 (score: 0.160) ENSXETP00000016486 (score: 0.152)	From Inparanoid:20070104
E. coli O157	YECG	From ECOO157CYC
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Notes

Families

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See Help:Gene_accessions for help with entering information into the Gene Accessions table.

Database	Accession	Notes
Superfamily (EcoliWiki Page)	SUPERFAMILY:52402
Pfam (EcoliWiki Page)	PF00582 Universal stress protein family
EcoCyc	EcoCyc:G7031	Escherichia coli str. K-12 substr. MG1655
EcoGene	EcoGene:EG12862	Escherichia coli str. K-12 substr. MG1655
RegulonDB	RegulonDB:ECK120003618	Escherichia coli str. K-12 substr. MG1655
EchoBASE	EchoBASE:EB2704	Escherichia coli str. K-12 substr. MG1655
ASAP	ASAP:ABE-0006316	Escherichia coli str. K-12 substr. MG1655
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Name	URL	Comments
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References

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↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 Riley, M. et al. (2006) Nucleic Acids Res 34:1-6 (corrected supplemental data from B. Wanner)
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 EcoCyc (release 10.6; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^3.0 ^3.1 EcoCyc (release 11.1; 2007) Keseler, IM et al. (2005) Nucleic Acids Res. 33(Database issue):D334-7
↑ ^4.0 ^4.1 EcoGene: Rudd, KE (2000) EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res 28:60-4.
↑ Nachin, L et al. (2005) Differential roles of the universal stress proteins of Escherichia coli in oxidative stress resistance, adhesion, and motility. J. Bacteriol. 187 6265-72 PubMed
↑ ^6.0 ^6.1 Gustavsson, N et al. (2002) The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage. Mol. Microbiol. 43 107-17 PubMed
↑ Heermann, R et al. (2009) The universal stress protein UspC scaffolds the KdpD/KdpE signaling cascade of Escherichia coli under salt stress. J. Mol. Biol. 386 134-48 PubMed
↑ Heermann, R et al. (2009) Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling. BMC Microbiol. 9 133 PubMed
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Arifuzzaman, M et al. (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 686-91 PubMed
↑ Finn, RD et al. (2010) The Pfam protein families database. Nucleic Acids Res. 38 D211-22 PubMed

uspC:On One Page

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Notes

Gene

Nomenclature

Notes

Location(s) and DNA Sequence

Notes

Sequence Features

Notes

Alleles and Phenotypes

Notes

Genetic Interactions

Notes

Genetic Resources

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Accessions in Other Databases

Notes

Links

Product(s)

Nomenclature

Notes

Function

Notes

Localization

Notes

Structure and Physical Properties

Structure figures

Notes

Gene Product Resources

Notes

Accessions in Other Databases

Notes

Links

Expression

Overview

Cellular Levels

Notes

Transcription and Transcriptional Regulation

Notes

Translation and Regulation of Translation

Notes

Turnover and Regulation of Turnover

Notes

Experimental

Notes

Accessions Related to uspC Expression

Notes

Links

Evolution

Homologs in Other Organisms

Do-It-Yourself Web Tools

Notes

Families

Notes

Links

References

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